血液灌流联合血液透析治疗尿毒症的临床观察

Objective To compare the curative effect of hemodialysis (HD) with hemoperfusion combined hemodialysis (HP + HD). Methods 30 patients with uremia who needed long-term hemodialysis were considered as group-treated with HP + HD, another control group(n = 28) as interfered one- treated with HD alone. Blood uremia nitrogen(BUN), creatinine(Cr), β2- microglobulin(β2- MG) , parathyroid hor-mone(PTH), hemoglobin(Hb) and clinical manifestation of the patients were obscrved before and after the treatment of 1 month.Results Serum β2- MG and PTH in the group-treated significantly decreased, and Hb was significantly increased and the amelioration of clinical symptom was more superior as compared with those before treatment and in control group, there were no significant difference to the clearance rates of BUN and Cr. Conclusion Using HP + HD could clear up β- MG, PTH and ameliorate clinical symptom better than using HD alone.     

High dose niacin in the treatment of acne vulgaris: a pilot study

Introduction Acne patients are frequently associated with abnormal lipid profile. It may be useful to apply high dose of niacin that regulates the lipid profile along with acne treatment. There is no report about high dose of niacin in treatment of acne. Objective To evaluate the therapeutic effect and safety of high-dose niacin in acne vulgaris. Methods Acne patients were randomly allocated to two treatment groups. Both groups were treated orally with the tablets for 12 weeks; the niacin group at an increasing dose of niacin tablet: 2000 mg(40 mg/kg/d). The control group(nicotinamide group) at a dose of nicotinamide tablet: 600 mg(10 mg/kg/d). All patients were asked not to consume certain foods such as milk and alcohol. A high-protein, low-fat and low-glycemic-load diet was recommended in both groups. Results A total of 108 patients were finished the study. Niacin group: 56 patients; control group: 52 patients. After 12 weeks of treatment, niacin and nicotinamide caused improvement in acne patients. Percentage Improvement in the niacin group(82.37±7.837) %was significantly higher than in the nicotinamide group(63.19±10.18)%, P0.01. The number of successful cases in the niacin group was significantly higher than in the nicotinamide group after 12 weeks of treatment,(χ~2 = 10.55, P0.01). Conclusions High dose niacin can really do it work in treatment of acne vulgaris. The therapeutic effcct of High dose of niacin in treatment of acne vulgaris is more effective than nicotinamide.     

脾切除对肝纤维化大鼠肝脏PDGF-B表达及血清PDGF-BB水平的影响

Objective To explore the effects of splenectomy on hepatic fibrosis and on the expression of PDGF-B in the liver and PDGF-BB in the serum of rats with hepatic fibrosis. Methods By hypodermic injection CCl4, we established 65 rat models with hepatic fibrosis, splenectomies were performed in the three groups at different phases: before hypodermic injection CCl4 (A group), five weeks after hypodermic injection CCl4 (B group), and ten weeks hypodermic injection CCl4 (C group). The control groups were established at the same time, with samples of the livers and serum of the rats taken in different phases. The expressions of PDGF in the liver were detected by immunohistochemistry technique and the degree of hepatic fibrosis was detected by HE staining. The serum levels of PDGF-BB were analyzed by ELISA technique. Results Absorbance values of PDGF-B in the experimental group were significantly lower than the control groups (P＜0. 05). Serum levels of PDGF-BB of the rats after splenectomy were significantly lower than those in the control groups (P＜0.05). HE and Masson's staining showed that the progression of Hepatic fibrosis was slow in the A group. Hepatic pathologic state was significantly relieved in the B group and the inflammation and fibrosis was relieved in the C group. Conclusion Earlier period splenectomy could delay the proceeding of experimental hepatic fibrosis. After splenectomy the decline in the level of PDGF may be one of the mechanisms causing the delay.     

Effects of neurofeedback on the short-term memory and continuous attention ofpatients with moderate traumatic brain injury: A preliminary randomized controlled clinical trial

Purpose: There are some studies which showed neurofeedback therapy (NFT) can be effective in clients with traumatic brain injury (TBI) history. However, randomized controlled clinical trials are still needed for evaluation of this treatment as a standard option. This preliminary study was aimed to evaluate the effect of NFT on continuous attention (CA) and short-term memory (STM) of clients with moderate TBI using a randomized controlled clinical trial (RCT). Methods: In this preliminary RCT, seventeen eligible patients with moderate TBI were randomly allocated in two intervention and control groups. All the patients were evaluated for CA and STM using the visual continuous attention test and Wechsler memory scale-4th edition (WMS-IV) test, respectively, both at the time of inclusion to the project and four weeks later. The intervention group participated in 20 sessions of NFT through the first four weeks. Conversely, the control group participated in the same NF sessions from the fifth week to eighth week of the project. Results: Eight subjects in the intervention group and five subjects in the control group completed the study. The mean and standard deviation of participants'' age were (26.75 ± 15.16) years and (27.60 ± 8.17) years in experiment and control groups, respectively. All of the subjects were male. No significant improvement was observed in any variables of the visual continuous attention test and WMS-IV test between two groups (p≥0.05). Conclusion: Based on our literature review, it seems that our study is the only study performed on the effect of NFT on TBI patients with control group. NFT has no effect on CA and STM in patients with moderate TBI. More RCTs with large sample sizes, more sessions of treatment, longer time of follow-up and different protocols are recommended.     

Low expression of vascular endothelial growth factor and high serum level ofcyclic guanine monophosphate as the risk factors of femoral head osteonecrosis inalcohol-exposed Wistar rat

Purpose:Severe damage to the femoral head in patients with osteonecrosis has a high impact on morbidity.Despite early diagnosis,the treatment outcome is still unsatisfactory.This study aimed to explore the expression of vascular endothelial growth factor(VEGF)and cyclic guanine monophosphate(cGMP)serum level as the risk factors of femoral head osteonecrosis in alcohol-exposed Wistar rats.Methods:This was an exper imental study using randomized post-test only control group design,with samples using 10-14 weeks Wistar male rats.Rats were then divided into 6 groups:3 groups without intervention,and 3 groups with intervention using 40%alcohol given perorally.Each one group from intervention and control group was euthanized by the end of the week for 3 consecutive weeks.Proximal femurs were examined under microscope for osteonecrosis,immunohistochemically for VEGF,and blood serum for cGMP levels.Results:VEGF expression in the femoral head of alcohol-exposed Wistar rats was lower than those not exposed to alcohol(p<0.005).Blood serum cGMP levels of alcohol-exposed Wistar rats were higher than those not exposed to alcohol(p<0.005).The number of necrotic osteocytes in the femoral head of Wistar rats exposed to alcohol was greater than those not exposed to alcohol(p<0.005).There are significant differences between VEGF,cGMP levels,and number of necrotic osteocytes in the control group and treatment at 1st,2nd'and 3rd week(p<0.005).Conclusions:Based on the result of this study,VEGF and cGMP may be considered as diagnostic bio-markers for alcohol-induced femoral head osteonecrosis.     

Randomly study on erectile dysfunction treated by trazodone

Objective: To observe the efficacy and tolerance of Trazodone in Treating erectile dysfunction (ED). Methods: 65 patients were randomly assigned into two groups. Patients in Trazodone group were treated with trazodone from 50 mg a day gradually increased 150 mg a day over 4 weeks. Patients in control group were given placebo. The IIEF~*.5 was used to evaluate the effects before and after interference. Results: the effective rates were 40%, while the response rates of control group were 16.7%. There was significant difference in trazodone group before and after treatment. The side effects were slight dizziness, fatigue and sleepness. Conclusions: Administration of Trazodone significantly improved the sexual function in patients suffered from mild and moderate ED.     

绿茶多酚改善环孢素A抑制血管舒张的作用

Objective To observe the alleviation effect of green tea polyphenols (GTP) on cyclosporine A (CsA)-induced inhibition of vasodilation, and to study the underlying mechanism. Methods Thirty SD rats were randomly divided into three groups: CsA group, control group and CsA + GTP group. Five weeks after the treatment, the body weight, kidney function (BUN, Cr) of the rats were measured. Then thoracic aorta rings were mounted on a bath system, and the Ach-induced vasodilation, the effect of L-NAME and indomethacin pretreatment on the vasodilation and the denuded vasodilation were evaluated. The contents of nitric oxide (NO) in the vascular tissues were measured. Results Five weeks later, the body weight of the rats in CsA group (253.2 ±8.1) g was lighter than that in control group (292.1 ±9.5) g (P < 0.05);the body weight in CsA + GTP group (287.9 ± 9.7) g was heavier than that in CsA group ( P < 0.05);The levels of BUN and Cr in CsA group were higher than in control group (P <0.05);The levels of BUN and Cr in CsA + GTP group were lower than in CsA group (P <0.05). The maximal response for Achinduced vasodilation in CsA group was (42.5 ±4.3)% , significantly lower than (81.2 ±7. 6)% in control group and (70.1 ± 6.5) % in CsA + GTP group (both/P < 0.05). After pretreatment with L-NAME, the vasodilation in CsA group and CsA + GTP group was (40.3 ±3.7)% and (45.8 ±4.2)% respectively, lower than in control group (79. 4 ± 6. 8)% ;After pretreatment with indomethacin, the vasodilation in control group and CsA + GTP group was higher than in CsA group (both P < 0.05). The vasodilation in the denuded groups was inhibited, but there was no significant difference between groups (P>0.05). In CsA group, the content of NO in vascular tissues was lower than that in control group and CsA + GTP group (both P < 0.05). Conclusion CsA might decrease the NO content in vascular tissues and induce abnormal endothelium-dependent vasodilation which is mediated by NO. The administration of GTP could increase the NO content and alleviate the CsA-induced inhibition of the endothelium-dependent vasodilation.     

绿茶多酚改善环孢素A抑制血管舒张的作用

Objective To observe the alleviation effect of green tea polyphenols (GTP) on cyclosporine A (CsA)-induced inhibition of vasodilation, and to study the underlying mechanism. Methods Thirty SD rats were randomly divided into three groups: CsA group, control group and CsA + GTP group. Five weeks after the treatment, the body weight, kidney function (BUN, Cr) of the rats were measured. Then thoracic aorta rings were mounted on a bath system, and the Ach-induced vasodilation, the effect of L-NAME and indomethacin pretreatment on the vasodilation and the denuded vasodilation were evaluated. The contents of nitric oxide (NO) in the vascular tissues were measured. Results Five weeks later, the body weight of the rats in CsA group (253.2 ±8.1) g was lighter than that in control group (292.1 ±9.5) g (P < 0.05);the body weight in CsA + GTP group (287.9 ± 9.7) g was heavier than that in CsA group ( P < 0.05);The levels of BUN and Cr in CsA group were higher than in control group (P <0.05);The levels of BUN and Cr in CsA + GTP group were lower than in CsA group (P <0.05). The maximal response for Achinduced vasodilation in CsA group was (42.5 ±4.3)% , significantly lower than (81.2 ±7. 6)% in control group and (70.1 ± 6.5) % in CsA + GTP group (both/P < 0.05). After pretreatment with L-NAME, the vasodilation in CsA group and CsA + GTP group was (40.3 ±3.7)% and (45.8 ±4.2)% respectively, lower than in control group (79. 4 ± 6. 8)% ;After pretreatment with indomethacin, the vasodilation in control group and CsA + GTP group was higher than in CsA group (both P < 0.05). The vasodilation in the denuded groups was inhibited, but there was no significant difference between groups (P>0.05). In CsA group, the content of NO in vascular tissues was lower than that in control group and CsA + GTP group (both P < 0.05). Conclusion CsA might decrease the NO content in vascular tissues and induce abnormal endothelium-dependent vasodilation which is mediated by NO. The administration of GTP could increase the NO content and alleviate the CsA-induced inhibition of the endothelium-dependent vasodilation.     

Micro-recanalization in a biodegradable graft for reconstruction of the vas deferens is enhanced by sildenafil citrate

This study investigated the effect of sildenafil citrate on micro-recanalization and neovascularization, which were previously demonstrated in a rat model using biodegradable grafts （BGs） for vas deferens reconstruction. A total of 24 male rats underwent bilateral vasectomy with removal of a 0.5-cm vasal segment and were randomly assigned to four groups. Groups 1 and 2 underwent immediate vasovasostomy. Groups 3 and 4 underwent interposition of a 0.5-cm BG in the vasal gap. Groups 1 and 3 were given 5 mg kg-1 day-1 oral sildenafil. Other groups were given placebo. Rats were housed with females 12 weeks postoperatively. Reconstructed vasal segments were harvested 16 weeks postoperatively and analyzed histologically. Fluid from the distal vasal stump was analyzed for motile sperm. Urine samples obtained 16 weeks postoperatively were analyzed for cGMP levels. cGMP levels in rats treated with sildenafil were signifcantly higher than in control rats. No pregnancies were sired by grafted groups. In all, 5/6 rats in group 1 and 3/6 rats in group 2 sired litters. No motile sperm were noted in the vasal fluid of the grafted groups. Motile sperm were noted in all rats in group 1 and in 5/6 rats in group 2. In addition, 29 and 4 microcanals were detected in the sildenafil and placebo groups, respectively （P = 0.023）. No microcanal exceeded 3 mm in length. An average of 12 and 28 blood vessels per graft were noted in the placebo and sildenafil groups, respectively （P 〈 0.0001）. In conclusion, sildenafil enhances micro-recanalization and neovascularization in BG used for vas deferens reconstruction, but does not increase the microcanal length after 16 weeks.     

血液透析联合血液灌流治疗尿毒症患者皮肤瘙痒的疗效

目的 观察血液透析联合血液灌流治疗尿毒症皮肤瘙痒患者的临床疗效.方法 选择我院72例维持性血液透析伴皮肤瘙痒患者,采用数字表法随机分为观察组(HD+ HP组)和对照组(HD组),每组各36例.对照组采用单纯血液透析(HD)治疗,每周3次,每次4小时;观察组在常规血液透析基础上加用2～3次/月的组合型人工肾治疗[血液透析(HD)联合血液灌流(HP)治疗].检测两组患者治疗前后β2-微球蛋白(β2-MG)、甲状旁腺激素(PTH),并观察两组患者皮肤瘙痒改善情况.结果 治疗2个月后观察组患者血β2-MG、PTH比对照组明显下降,差异有统计学意义(P＜0.05),皮肤瘙痒的程度明显减轻.结论 血液透析联合血液灌流可有效的清除血液中大分子毒素;有效缓解长期血液透析患者皮肤瘙痒症状,改善预后,提高了尿毒症患者生存质量.     

维持性血液透析联合血液灌流：一种安全有效的模式

目的 探讨维持性血液透析（MHD）联合血液灌流（HP）治疗能否提高中、大分子毒素的清除率,能否改善MHD患者的生活质量并降低其病死率。 方法 采用前瞻性、随机、对照性研究。选取100例MHD患者,4周试验导入期后随机分为2组。HD+HP组（n=51）采取维持性单纯血液透析（2次/周）和HD+HP（1次/周）治疗;HD组（n=49）采取单纯血液透析（3次/周）治疗。平均随访2年。主要观察终点为患者死亡;次要观察终点为常规临床指标、瘦素、超敏C反应蛋白（hsCRP）、白细胞介素6（IL-6）、β2微球蛋白（β2-MG）、甲状旁腺激素（PTH）、肿瘤坏死因子α（TNF-α）和SF-36量表生活质量指数。 结果 2年观察期结束时,HD+HP组患者的瘦素、hsCRP、PTH、IL-6、β2-MG和TNF-α 的血清浓度和收缩压、舒张压、心率、心胸比、左室质量指数（LVMI）、EPO剂量和降压药的种类均低于HD组（均P < 0.05）;HD+HP组患者的血红蛋白（Hb）浓度、左心室射血分数（EF）、体质量指数（BMI）均高于HD组（均P < 0.05）;2组患者的血清白蛋白（Alb）浓度、血清铁（SI）浓度、总铁结合力（TIBC）、Kt/V、每分心输出量（CO）和二尖瓣峰值流速比（E/A）差异均无统计学意义。2年观察期结束后,SF-36量表显示HD+HP组患者的生活质量明显好于HD组,总评价值显示HD+HP组患者总分高于HD组（P < 0.05）。2年观察期间的Kaplan-Meier生存曲线显示HD+HP组患者具有明显的生存优势,Log-rank检验P < 0.05。HD+HP组患者行HD+HP时未发生严重的不良反应。 结论 HD+HP清除患者体内中大分子毒素的效果明显优于单纯性HD,同时在改善MHD患者的生活质量和提高其生存率方面有潜在的优势。     

血液灌流联合血液透析治疗尿毒症的临床观察

目的 比较血液灌流联合血液透析与单独血液透析对尿毒症的治疗效果.方法 将30例血液透析患者进入血液灌流联合血液透析治疗(治疗组),并与单独血液透析治疗的28例患者(对照组)的疗效进行对比分析,观察比较临床症状改善情况、治疗前、治疗后1个月血液尿素氮、肌酐、β2-微球蛋白、甲状旁腺激素及血红蛋白的指标.结果 治疗组临床症状的改善优于对照组;治疗组β-微球蛋白、甲状旁腺激素、血红蛋白与治疗前比较差异有统计学意义(P<0.01);对照组β2-微球蛋白、甲状旁腺激素、血红蛋白与治疗前比较则无统计学意义(P>0.05);两组间各指标比较差异有统计学意义(P<0.01);两种方法在清除血液尿素氮、肌酐方面比较均无统计学意义(P>0.05).结论 血液灌流联合血液透析治疗能更好地清除体内β2-微球蛋白、甲状旁腺激素等中分子物质,临床症状改善效果优于血液透析.     

两种不同血液净化方式对血清钙磷和甲状旁腺激素清除的对比研究

目的 探讨血液灌流串联血液透析与血液透析滤过对尿毒症患者血清中钙、磷、甲状旁腺激素清除的效果.方法 选择长期维持并规律性进行血液透析的尿毒症患者40例,按随机数字表法分为血液灌流串联血液透析组(20例),每2周常规血液透析治疗5次,血液灌流串联血液透析治疗1次;血液透析滤过组(20例),每2周常规血液透析治疗5次,血液透析滤过治疗1次.两组疗程均为12周.分别记录首次透析前、后及治疗4、12周时患者血清钙、磷、甲状旁腺激素值,并对两组进行比较.结果 两组均可使血清钙、磷、甲状旁腺激素值下降.首次治疗清除效果均显著(P<0.01);治疗4、12周时,血清钙、磷的下降不及甲状旁腺激素下降明显,但血液灌流串联血液透析组较血液透析滤过组清除血清钙、磷明显(P<0.05),清除甲状旁腺激素更明显,且差异有统计学意义(P<0.01).结论 血液灌流串联血液透析能有效地清除尿毒症患者血清中的钙、磷和甲状旁腺激素,且优于血液透析滤过,有临床推广价值.     

不同血液净化方式对尿毒症皮肤瘙痒的疗效观察

目的探讨不同血液净化方式对尿毒症皮肤瘙痒的治疗效果。方法选择70例尿毒症规律性血液透析伴皮肤瘙痒患者,分为血液灌流串联血液透析（HP／HD组）、血液透析滤过（HDF组）、高通量透析（HFD组）、普通血液透析（HD组）进行治疗。观察皮肤瘙痒等临床症状缓解情况及血清甲状旁腺素等指标变化。结果HP／HD组、HDF组、HFD组治疗前后,血清PTH水平下降,皮肤瘙痒明显缓解;与HD组比较差异有统计学意义（P〈0．01或P〈0．05）。结论血液灌流串联血液透析和血液透析滤过、高通量透析较普通血液透析能更有效的清除PTH,可有效缓解皮肤瘙痒等症状。     

不同透析方式对维持性血液透析患者微炎症状态的影响

目的：比较低通量血液透析（LFHD）、高通量血液透析（HFHD）、血液透析＋血液灌流（HD＋HP）3种血液净化方式对维持性血液透析（MHD）患者微炎症状态的影响。方法：32例MHD患者,交叉对照设计,每例患者每隔4周随机接受LFHD、HFHD、HD＋HP3种之一治疗,每种治疗持续12周,清洗期4周。治疗前、后检测超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子α（TNF-α）和β2微球蛋白（β2-MG）的水平。比较3种治疗对血清hs-CRP、IL-6、TNF-α、β2-MG的影响。结果：（1）3种治疗方式治疗前hs-CRP、IL-6、TNF-α、β2-MG、血清白蛋白（Alb）水平组间比较,差异无统计学意义。治疗12周后,LFHD组hs-CRP、IL-6、TNF-α、β2-MG水平均较治疗前上升;HFHD组及HD＋HP组hs-CRP、IL-6、TNF-α、β2-MG水平均较治疗前下降（P〈0.05或0.01）,HD＋HP组较HFHD组下降更明显,两组差异有统计学意义（P〈0.01）;三组Alb水平与治疗前相比差异无统计学意义（P〉0.05）。（2）单次治疗前后,每两组之间相比hs-CRP、IL-6、TNF-α、β2-MG下降差异均有统计学意义（P〈0.01）,HD＋HP组下降最明显。结论：HFHD、HD＋HP可以降低MHD患者的血清hs-CRP、IL-6、TNF-α、β2-MG水平,改善微炎症状态,以HD＋HP效果最好。     

不同血液净化方式对尿毒症透析患者血中细胞因子清除的临床应用

目的 研究不同血液净化方式对尿毒症透析患者血中细胞因子的清除效果.方法 将2006年4月至2009年2月在我院血液净化中心透析的45例患者按随机数字表法分为(1)血液透析联合血液灌流组;(2)血液透析滤过组;(3)HD组,血液透析组,每组15例.血液透析联合血液灌流组、血液透析滤过组每周治疗1次,每组患者治疗3次,中间间隔1周,第1次及第3次治疗前、后各从动脉端采血5 ml,并留取正常健康对照组血液,整批送检.测定治疗前、后血清细胞因子的浓度.结果 血液灌流联合血液透析组、血液透析滤过组及血液透析组治疗前、后白细胞介素1β、白细胞介素6、肿瘤坏死因子α浓度与健康对照组比较差异有统计学意义(P＜0.01);血液透析组患者血肿瘤坏死因子α、白细胞介素1β、白细胞介素6水平分别为(3±10)ng/L、(4±9)ng/L、(4±9)ng/L,治疗前、后差值比较分别为176.0%、141.0%、187.0%,血液透析滤过组血肿瘤坏死因子α、白细胞介素1β、白细胞介素6水平分别为(39±15)ng/L、(36±14)ng/L、(45±16)ng/L,治疗前后差值比较分别为24.6%、22.1%、29.8%,血液灌流联合血液透析组血肿瘤坏死因子α、白细胞介素1β、白细胞介素6水平分别为(48±16)ng/L、(38±15)ng/L、(50±14)ng/L,治疗前差值比较分别为27.8%、23.9%、32.3%,3组患者血肿瘤坏死因子α、白细胞介素1β、白细胞介素6水平间比较差异有统计学意义(t分别=17.39、11.24、21.89,P均＜0.01).结论 不同的血液净化方式对各类细胞因子的清除效果不同,其中液灌流联合血液透析组及血液透析滤过组治疗埘细胞因子清除有效,血液透析组治疗对细胞因子清除基本无效,液灌流联合血液透析组及血液透析滤过组细胞因子清除效果与血液透析滤过组比较差异无统计学意义(P＞0.05).     

The effect of high-flux hemodialysis on dialysis-associated amyloidosis

Amyloidosis is an important cause of mortality and morbidity in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD). In this study, depending on the idea that the clearance of middle and high molecular weight toxins could be improved, we aimed to investigate the effect of high-flux dialyzer on clearance of beta-2 microglobulin (beta2-MG) and calcium (Ca) phosphorus (P) metabolism in patients under HD treatment. Forty-eight patients with ESRD under chronic HD treatment were included in the study. All patients were randomized into two groups, and HD was performed with low-flux or high-flux dialyzer for 6 months. In the high-flux group, the reduction of beta2-MG and P levels during dialysis was significantly higher when compared with the low-flux group (p<0.001). During the follow-up period, while beta2-MG levels decreased significantly in the high-flux group (p<0.05), there was an increase in the low-flux group (p<0.05). As a result, our findings suggest that use of high-flux dialyzer can be an efficient alternative in terms of controlling the clearance of beta2-MG and impaired Ca and P metabolism. These beneficial effects of high-flux dialyzers are probably mediated by the improved clearance of middle and high molecular weight toxins.     

组合型人工肾对尿毒症透析患者血管活性物质的影响

目的 探讨组合型人工肾(血液灌流联合血液透析)对尿毒症患者血管活性物质的影响.方法 将符合入选标准的48例尿毒症合并难治性高血压的患者按随机数字表法分为组合型人工肾组和血液透析组,检测患者治疗前、后肾素活性、内皮素1、血管紧张素Ⅱ水平,观察血压的变化情况.结果 治疗3个月后,组合型人工肾组肾素活性、内皮素1、血管紧张素...     

亚低温对创伤性脑损伤患者脑脊液β2-微球蛋白的影响

目的 通过随机分组研究亚低温对创伤性脑损伤患者脑脊液β2-微球蛋白水平的影响.方法 将36例重型颅脑损伤患者随机分为亚低温治疗组及常温治疗组,研究在不同时间点脑脊液β2-微球蛋白的变化,并结合预后判断分析亚低温对重型颅脑损伤患者的影响.结果 在治疗各时间点上脑脊液β2-微球蛋白含量为先增高后降低,两组比较发现,亚低温组...