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目的分析中国新型冠状病毒肺炎(COVID-19)的时空分布特征及相关因素,为COVID-19防控提供依据。方法基于2020年1月21日至3月23日中国258个城市的COVID-19发病率、人口流动(湖北省武汉市迁入)、社会人口学、地理信息数据,进行空间自相关和热点分析,揭示COVID-19流行的空间异质性,识别热点区域。利用地理加权回归模型结合线性回归模型,探讨空间异质性的相关因素。结果 2020年1月21日至3月23日,258个城市累计报告29 789例COVID-19病例,COVID-19流行总体呈空间聚集性(Moran’s I=0.436,Z=25.363,P<0.001)。各地的百度迁徙指数(武汉市迁入)与COVID-19发病关联有统计学意义(t=14.550,P<0.001),百度迁徙指数表现出正向效应(β:0.564~0.565)。结论中国COVID-19流行存在空间异质性,武汉市人口迁入多的地区报告发病水平更高。对新发传染病的时空特征理解有助于疾病流行的早期预警和控制。 相似文献
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《Mayo Clinic proceedings. Mayo Clinic》2021,96(12):3030-3041
ObjectiveTo evaluate clinical characteristics of patients admitted to the hospital with coronavirus disease 2019 (COVID-19) in Southern United States and development as well as validation of a mortality risk prediction model.Patients and MethodsSouthern Louisiana was an early hotspot during the pandemic, which provided a large collection of clinical data on inpatients with COVID-19. We designed a risk stratification model to assess the mortality risk for patients admitted to the hospital with COVID-19. Data from 1673 consecutive patients diagnosed with COVID-19 infection and hospitalized between March 1, 2020, and April 30, 2020, was used to create an 11-factor mortality risk model based on baseline comorbidity, organ injury, and laboratory results. The risk model was validated using a subsequent cohort of 2067 consecutive hospitalized patients admitted between June 1, 2020, and December 31, 2020.ResultsThe resultant model has an area under the curve of 0.783 (95% CI, 0.76 to 0.81), with an optimal sensitivity of 0.74 and specificity of 0.69 for predicting mortality. Validation of this model in a subsequent cohort of 2067 consecutively hospitalized patients yielded comparable prognostic performance.ConclusionWe have developed an easy-to-use, robust model for systematically evaluating patients presenting to acute care settings with COVID-19 infection. 相似文献
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Ajay Kumar Gupta Neena Katoch Rachna Gulati Vikas Kumar Sharmendra Singh Ketan Garg 《急性病杂志》2021,10(6):252-257
Objectives: To determine COVID-19 mortality and its risk factors in hospitalized patients at of a tertiary care center in north India. Methods: A retrospective observational study was conducted of patients who were hospitalized from May 2020 to January 2021. The in-hospital mortality was assessed, and demographic variables and comorbidities between COVID-19 deaths and survivors were compared. Results: A total of 24000 patients were admitted during the study period, among which 17000 had shown positive results of the RT-PCR test for COVID-19. The total mortality was 329 patients (1.37%), among which 232 (70.52%) succumbed due to COVID-19, and 97 (29.48%) died due to other illnesses. The mean age of the patients was (64.09±16.99) years. The mean age was significantly higher in COVID-19 related deaths [(67.63±13.78) years] as compared to that of the survivors [(60.52±19.5) years] (P<0.001). Compared to COVID-19 survivors, there were more males (72.41% v.s. 61.5%) and less females (27.59% v.s. 38.5%) in COVID-19 related deaths (P=0.001). Comorbidities such as hypertension, diabetes mellitus, and chronic kidney disease showed a significant correlation with COVID-19 mortality with an adjusted odds ratio of 2.389 (95% CI: 1.465-2.982), 3.891 (95% CI: 2.059-5.392), and 6.358 (95% CI: 5.675-10.564), respectively. Conclusions: Elderly males with comorbidities have higher risk for mortality related to COVID-19. Ongoing vaccination drive is rightfully prioritised to serve the high-risk category first. 相似文献
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《Journal of infection and chemotherapy》2023,29(3):333-338
IntroductionThe Plurinational State of Bolivia (Bolivia) has experienced four major waves of coronavirus disease 2019 (COVID-19) so far. Although the ministry of health has been tracking morbidity and mortality through each wave, epidemiology of COVID-19 in Bolivia is not well defined, despite a need for more accurate measurement of the number of cases and deaths to allow for forecasting of the pandemic. This study examined prevalence of COVID-19 at community level, determinants of its occurrence and vaccine effectiveness.MethodsWe conducted a cross-sectional study in La Paz city on 2,775 individuals between March 2020 and February 2022. A structured questionnaire was used to collect data on COVID-19 morbidity, mortality and vaccination status.ResultsOf the 2,775 participants, 1,586 (57.1%) were infected with COVID-19, and 187 (6.7%) were suspected cases. The mortality rate was 2.9%. Sinopharm, Johnson & Johnson, Gamaleya, Pfizer-BioNtech, Moderna and AstraZeneka vaccines are in use, and all vaccines have demonstrated effectiveness in reducing the risk of onset. Risk for mortality was significantly lower in the vaccinated group with an odds ratio of 0.037 (95% confidential interval: 0.01–0.10, p-value: <0.001).ConclusionsActual prevalence of COVID-19 in La Paz (the prevalence rate: 63.8%, including suspected case) was higher than that reported by the Ministry of Health and Sports in Bolivia (7.5%). In addition, vaccination has contributed significantly to the control of the COVID-19 epidemic in Bolivia. We believe that our report will be useful for COVID-19 prevention strategies in Bolivia for the future. 相似文献
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目的描述并探讨甘肃省新型冠状病毒肺炎(COVID-19)疫情的时间风险特征。方法收集截至2020年2月16日甘肃省各县(区)报告的COVID-19的发病数、相应县(区)人口数等数据,运用空间统计学的方法计算各县(区)的时间风险指数频率指数(α)、持续时间频率(β)和强度指数(γ)。结果全局自相关分析发现,α的Moran’s I系数为0.115,提示未来COVID-19发病频率增加概率较小。γ的Moran’s I系数为0.070,说明COVID-19确诊病例不会集中出现,疫情的发病强度较低。甘肃省COVID-19疫情的α、β存在全局空间自相关性(P<0.05),γ不存在全局空间自相关性(P>0.05)。α局部空间自相关分析发现区域(主要分布于兰州市城关区、七里河区、安宁区、红古区、皋兰县和榆中县)内存在高-高聚集性(P<0.05)。β局部空间自相关分析发现区域(主要分布于兰州市城关区、七里河区、西固区、安宁区、皋兰县和榆中县)内存在高-高聚集性(P<0.05)。结论结果提示兰州市大部分县(区)呈现高风险聚集性,但发病强度较低;全省在疫情期间采取的各项防控措施及时、有效。 相似文献
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Kristine G. Williams MD MPH Mario Schootman PhD Kimberly S. Quayle MD Jim Struthers BA David M. Jaffe MD 《Academic emergency medicine》2003,10(7):743-752
OBJECTIVES: To use a geographic information system (GIS) and spatial statistics to describe the geographic variation of burn injuries in children 0-14 years of age in a major metropolitan area. METHODS: The authors reviewed patient records for burn injuries treated during 1995 at the two children's hospitals in St. Louis. Patient addresses were matched to block groups using a GIS, and block group burn injury rates were calculated. Mapping software and Bayesian analysis were used to create maps of burn injury rates and risks in the city of St. Louis. RESULTS: Three hundred eleven children from the city of St. Louis were treated for burn injuries in 1995. The authors identified an area of high incidence for burn injuries in North St. Louis. The filtered rate contour was 6 per 1,000 children at risk, with block group rates within the area of 0 to 58.8 per 1,000 children at risk. Hierarchical Bayesian analysis of North St. Louis burn data revealed a relative risk range of 0.8771 to 1.182 for census tracts within North St. Louis, suggesting that there may be pockets of high risk within an already identified high-risk area. CONCLUSIONS: This study shows the utility of geographic mapping in providing information about injury patterns within a defined area. The combination of mapping injury rates and spatial statistical analysis provides a detailed level of injury surveillance, allowing for identification of small geographic areas with elevated rates of specific injuries. 相似文献
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《Journal of infection and chemotherapy》2022,28(4):554-557
The main objective of the study is to assess the impact of regional heterogeneity on the severity of COVID-19 in Japan. We included 27,865 cases registered between January 2020 and February 2021 in the COVID-19 Registry of Japan, to examine the relationship between the National Early Warning Score (NEWS) of COVID-19 patients on the day of admission and the prefecture where the patients live. A hierarchical Bayesian model was used to examine the random effect of each prefecture in addition to the patients’ backgrounds. Additionally, we compared the results of two models; one model included the number of beds secured for COVID-19 patients in each prefecture as one of the fixed effects, and the other model did not. The results indicated that the prefecture had a substantial impact on the severity of COVID-19 on admission, even when considering the effect of the number of beds separately. Our analysis revealed a possible association between regional heterogeneity and increased/decreased risk of severe COVID-19 infection on admission. This heterogeneity was derived not only from the number of beds secured in each prefecture but also from other factors. 相似文献
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Xin-Xin Wu Jin-Jian Yao Jin Qian Qi-Feng Huang Tang Deng Shuang-Qin Xu Hang-Fei Wang Qi Li Ji-Chao Peng Yang Yi Nan Li Yue Huang Xiao-Ran Liu 《急性病杂志》2022,11(1):1-11
Objective:To systematically evaluate the incidence of adverse reactions to coronavirus disease 2019(COVID-19)vaccination.Methods:We systematically searched PubMed,Embase,The Cochrane Library,Web of Science,CNKI,WanFang Data,and VIP Database from the inception of each database to August 31,2021.Randomized controlled clinical trials(RCTs)on the safety of different types of COVID-19 vaccines were retrieved and analyzed.A random or fixed-effects model was used with an odds ratio as the effect size.The quality of each reference was evaluated.The incidence of the adverse reactions of the placebo group and the vaccination group was compared.Heterogeneity and publication bias were taken care of by meta-regression and sub-group analyses.Results:A total of 13 articles were included,with 81287 subjects.Compared with the placebo group,the vaccination group showed a higher combined risk ratio(RR)of total adverse reactions(RR=1.67,95%CI:1.46-1.91,P<0.01),local adverse reactions(RR=2.86,95%CI:2.11-3.87,P<0.01),systemic adverse reactions(RR=1.25,95%CI:0.92-1.72,P=0.16),pain(RR=2.55,95%CI:1.75-3.70,P<0.01),swelling(RR=4.16,95%CI:1.71-10.17,P=0.002),fever(RR=2.34,95%CI:1.84-2.97,P<0.01),fatigue(RR=1.36,95%CI:1.32-1.41,P<0.01)and headache(RR=1.22,95%CI:1.18-1.26,P<0.01).The subgroup analysis showed the incidence of adverse reactions of the vaccination group after injection of the three COVID-19 vaccines(inactivated viral vaccines,mRNA vaccines and adenovirus vector vaccines)was higher than that of the placebo group,and the difference between the placebo group and the vaccination group in the mRNA vaccine subgroup and the adenovirus vector vaccine subgroup was statistically significant(P<0.01).The incidence of adverse reactions after injection of COVID-19 vaccine in subgroups of different ages was significantly higher than that in the placebo group(P<0.01).Conclusions:COVID-19 vaccines have a good safety,among which adenovirus vector vaccine has the highest incidence of adverse reactions.Both adolescents and adults vaccinated with novel coronavirus vaccine have a certain proportion of adverse reactions,but the symptoms are mild and can be relieved by themselves.Our meta-analysis can help boost global awareness of vaccine safety,promote mass vaccination,help build regional and global immune barriers and effectively curb the recurrency of COVID-19. 相似文献
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Hardeva Ram Nehara Kritika Khanna Atma Ram Chhimpa Sahaj Agrawal Avadusidda Arakeri Pramendra Sirohi 《急性病杂志》2021,10(4):155-161
Objective: To assess the knowledge, attitude, and practice (KAP) regarding COVID-19 among COVID-19 patients and their relation with the outcomes.Methods: This cross-sectional study was carried out among COVID-19 patients (18-year-old or older) consecutively admitted to a dedicated COVID-19 hospital located in northwest Rajasthan, India. Data regarding socio-demographic parameters, KAP, and primary composite outcome (admission to intensive care unit, mechanical ventilation, or in-hospital death) were collected. KAP scores were compared between different demographic variables and primary composite outcomes. Association between different demographic variables, primary composite outcomes, and KAP scores were determined through multivariate linear regression. Besides, the correlation among KAP scores was analyzed. Results: Out of the total 222 patients, most of them (65.76%) had average KAP scores towards COVID-19. The mean scores for knowledge were 7.88, with an overall correct rate of 71.63%; the mean attitude scores were 2.42, with an overall correct rate of 60.50%; the mean practice scores were 5.12, with an overall correct rate of 64.00%. Patients who met the primary composite outcomes had higher knowledge scores, but lower attitude and practice scores. The result showed a significant positive correlation between the level of education, socioeconomic class, and knowledge, attitude, and practice towards COVID-19. Knowledge towards COVID-19 was significantly associated with a positive attitude and good practice. Conclusions: Our findings show that adult COVID-19 patients have average KAP towards COVID-19 among COVID-19 patients. Poor attitude and practice towards COVID-19 are associated with adverse outcomes, so it is suggested to strengthen attitude and practice towards COVID-19 to improve the outcomes. 相似文献
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《Journal of infection and chemotherapy》2023,29(1):98-101
The impact of the COVID-19 pandemic on the incidence of microbial infections and other metrics related to antimicrobial resistance (AMR) has not yet been fully described. Using data from Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE), a national surveillance database system that routinely collects clinical and epidemiological data on microbial infections, infection control practices, antimicrobial use, and AMR emergence from participating institutions in Japan, we assessed the temporal changes in AMR-related metrics before and after the start of the COVID-19 pandemic. We found that an apparent decrease in the incidence of microbial infections in 2020 compared with 2019 may have been driven primarily by a reduction in bed occupancy, although the incidence showed a constant or even slightly increasing trend after adjusting for bed occupancy. Meanwhile, we found that the incidence of Streptococcus pneumoniae dramatically decreased from April 2020 onward, probably due to stringent non-pharmaceutical interventions against COVID-19. Antimicrobial use showed a weak increasing trend, while the use of hand sanitiser at the included medical institutions increased by about 50% in 2020 compared with 2019. 相似文献
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目的 了解新型冠状病毒肺炎(新冠肺炎)疫情防控措施对上海市嘉定区法定传染病流行的影响。方法 收集嘉定区2017—2021年法定传染病报告数据,分析比较新冠肺炎防控措施前后法定传染病发病率的变化。结果 在实施新冠肺炎防控措施下,2020年嘉定区法定传染病发病率为167.59/10万,较前3年平均发病率(421.04/10万)降低了60.20%(χ2=2 424.369,P<0.001);2021年法定传染病发病率为213.82/10万,较2017—2019年平均发病率降低了49.22%(χ2=1 578.996,P<0.001)。2020年和2021年乙类、丙类传染病发病率均低于2017—2019年平均发病率,其中乙类分别降低了38.79%和30.70%;丙类分别降低了71.23%和58.76%。2020年和2021年嘉定区肠道传染病、呼吸道传染病、经血液和性传播传染病发病率均低于2017—2019年平均发病率,其中2020年分别降低了59.27%、68.02%和36.52%,2021年分别降低了37.96%,56.37%和30.51%。2020年和2021年发病率最高的仍为... 相似文献
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《Mayo Clinic proceedings. Mayo Clinic》2021,96(10):2587-2597
ObjectiveTo assess the associations between coronavirus disease 2019 (COVID-19) infection and thromboembolism including myocardial infarction (MI), ischemic stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE).Patients and MethodsA self-controlled case-series study was conducted covering the whole of Scotland’s general population. The study population comprised individuals with confirmed (positive test) COVID-19 and at least one thromboembolic event between March 2018 and October 2020. Their incidence rates during the risk interval (5 days before to 56 days after the positive test) and the control interval (the remaining periods) were compared intrapersonally.ResultsAcross Scotland, 1449 individuals tested positive for COVID-19 and experienced a thromboembolic event. The risk of thromboembolism was significantly elevated over the whole risk period but highest in the 7 days following the positive test (incidence rate ratio, 12.01; 95% CI, 9.91 to 14.56) in all included individuals. The association was also present in individuals not originally hospitalized for COVID-19 (incidence rate ratio, 4.07; 95% CI, 2.83 to 5.85). Risk of MI, stroke, PE, and DVT were all significantly higher in the week following a positive test. The risk of PE and DVT was particularly high and remained significantly elevated even 56 days following the test.ConclusionConfirmed COVID-19 infection was associated with early elevations in risk with MI, ischemic stroke, and substantially stronger and prolonged elevations with DVT and PE both in hospital and community settings. Clinicians should consider thromboembolism, especially PE, among people with COVID-19 in the community. 相似文献