奥硝唑与甲硝唑治疗细菌性阴道病及滴虫性阴道炎的成本-效果分析

目的　评价奥硝唑与甲硝唑治疗细菌性阴道病及滴虫性阴道炎的疗效、不良反应及成本 效果。方法　将 80例细菌性阴道病及 4 0例滴虫性阴道炎患者随机分成 2组 ,分别口服奥硝唑 (A)和甲硝唑 (B) ,对奥硝唑与甲硝唑治疗细菌性阴道病及滴虫性阴道炎的疗效、不良反应并运用药物经济学成本效果分析法及成本进行评价。结果　奥硝唑与甲硝唑治疗细菌性阴道病及滴虫性阴道炎总有效率基本相同 ,分别为 95 .0 0 %和 90 .0 0 % (P >0 .0 5 ) ,92 .5 0 %和 95 .0 0 % (P >0 .0 5 ) ;不良反应发生率分别为 3.75 % ,17.5 % (P <0 .0 1) ;成本 效果比分别为 0 .78和 0 .80 ,0 .18和 0 .17(P <0 .0 1)。结论　奥硝唑与甲硝唑均能有效治疗细菌性阴道病及滴虫性阴道炎。甲硝唑成本 效果比优于奥硝唑。但其不良反应发生率与奥硝唑有显著性差异     

壳聚糖妇科栓治疗念珠菌阴道炎、细菌性阴道病疗效观察

目的：观察壳聚糖妇科栓治疗念珠菌性阴道炎、细菌性阴道病的临床疗效。方法：采用随机对比性，临床研究，将50例壳聚糖妇科栓治疗念珠菌阴道炎与50例达克宁栓治疗念珠菌阴道炎的疗效进行比较，将50例壳聚糖妇科栓治疗细菌性阴道病与50例甲硝唑栓治疗细菌性阴道病的疗效进行比较。结果：壳聚糖妇科栓治疗念珠菌阴道炎、细菌性阴道病的有效率分别为93．6％、79．1％，与常规药物达克宁栓、甲硝唑栓的治疗效果差异无统计学意义（P〉0．05）。结论：壳聚糖妇科栓治疗念珠菌阴道炎、细菌性阴道病安全、有效，其优势是在无完善的实验室检查情况下，仍可对患者进行治疗，并且不易产生耐药性．     

奥硝唑片治疗急性厌氧菌感染性疾病及阴道毛滴虫病的临床试验

目的：评价奥硝唑片治疗由厌氧菌所致的感染及滴虫所致阴道炎的临床疗效及其安全性。方法：采用多中心随机双盲双模拟平行对照研究方法,试验组口服奥硝唑,对照组口服替硝唑,共观察厌氧菌感染121例（外科60例,口腔科61例）,妇科阴道毛滴虫感染80例,奥硝唑500mg,bid;口腔科奥硝唑500mg,qd,首剂加倍。疗程3－10d。结果：奥硝唑与替硝唑治疗急性厌氧菌感染总有效率分别为98.4％及85％（P＜0．05）,细菌清除率分别为96．2％及90．7％（P＞0．05）;治疗滴虫性阴道炎的总有效率均为100％。奥硝唑和替硝唑的不良反应发生率分别为11．5％及28．3％（P＜0．05）。结论：奥硝唑片治疗急性厌氧菌感染和滴虫性阴道炎安全有效,不良反应少,优于同类药物替硝唑。     

奥硝唑栓和克林霉素磷酸酯栓联合阴道给药治疗细菌性阴道炎的疗效分析

目的研究奥硝唑栓联合克林霉素磷酸酯栓阴道给药对细菌性阴道炎的治疗价值。方法选取140例细菌性阴道炎患者,将其随机分为观察组和对照组各70例,观察组采用奥硝唑栓联合克林霉素磷酸酯栓阴道给药治疗,对照组单纯采用奥硝唑栓阴道给药治疗,比较两组患者治疗后的有效率和复发率。结果观察组和对照组治疗总有效率分别为98.6%和88.6%,复发率分别为2.9%和12.9%。观察组治疗有效率明显高于对照组,复发率明显低于对照组,两组对比差异显著P<0.05。结论奥硝唑栓联合克林霉素磷酸酯栓阴道给药治疗细菌性阴道炎疗效好,可明显减少细菌性阴道炎的复发率,值得临床推广使用。     

奥硝唑阴道泡腾片的制备及临床应用

目的：将奥硝唑制成阴道泡腾片剂。方法：选用枸橼酸、碳酸氢钠、黏合剂等药物辅料制备奥硝唑阴道泡腾片，用紫外分光光度法测定奥硝唑的含量，考察制剂的稳定性，并进行临床疗效观察。结果：本泡腾片处方合理，制备工艺简便，质量控制易行，稳定性良好。该制剂对细菌性阴道病、滴虫性阴道炎的总有效率分别为91．2％，95．71％。结论：泡腾片剂有望成为临床治疗细菌性阴道病、滴虫性阴道炎理想的新制剂。     

40例滴虫性阴道炎的临床治疗体会

目的探讨甲硝唑阴道泡腾片、奥硝唑片及妇洁舒洗液治疗滴虫性阴道炎的临床疗效。方法回顾40例采用上述方案治疗的滴虫性阴道炎患者的临床资料。结果40例患者痊愈29例（72．50％）、显效7例（17．50％）、有效2例（5．00％）和无效2V0（5．00％），总有效率95．00％，治疗期间均未观察到明显的药物不良反应。结论采用甲硝唑阴道泡腾片、奥硝唑片及妇洁舒洗液治疗滴虫性阴道炎，临床治疗效果好，安全性高。     

奥硝唑栓治疗滴虫性阴道炎的双盲随机对照多中心临床试验

目的评价奥硝唑栓(第3代硝基咪唑类抗滴虫药)治疗滴虫性阴道炎的临床疗效和安全性。方法用随机、双盲、平行对照、多中心临床试验,试验组113例,对照组112例,分别给予奥硝唑栓或甲硝唑栓,每日1枚(500mg)置入阴道,共5天。于停药3～5天、月经净后3～7天随访,观察症状、体征并进行阴道分泌物病原学检查。结果停药3-5天随访,2组的症状、体征和病原学指标均有明显改善,试验组、对照组的有效率(滴虫阴性率)分别为95.58%、97.32%,差异无统计学意义。月经后随访,试验组、对照组的有效率分别为89.38%、79.46%,2组比较有非常显著性差异(P<0.001)。试验组、对照组的药物不良反应发生率分别为9.57%、9.48%,差异无统计学意义。结论奥硝唑栓治疗滴虫性阴道炎安全、有效。     

联合治疗滴虫性阴道炎临床疗效观察

目的:观察硝呋太尔制霉素(朗依)阴道软胶囊联合奥硝唑分散片治疗滴虫性阴道炎临床疗效。方法:将462例滴虫性阴道炎患者随机分成3组,分别给予朗依栓(1粒/每晚,阴道上药)、奥硝唑分散片(0.5g,3次/日)和联合用药。治疗12天,观察3组临床效果及药物不良反应。结果:朗依栓组、奥硝唑分散片组和联合用药组有效率分别为64.54%(91/141)、34.15%(56/164)、90.45%(142/157)。朗依栓组较奥硝唑分散片组,有显著性差异(P<0.05);联合用药组对滴虫性阴道炎的治疗有效率均较单独使用朗依栓组及单独服用奥硝唑分散片组高,有非常显著性差异(P<0.01)。结论:朗依栓和奥硝唑分散片联合用药对治疗滴虫性阴道炎效果明显优于单独用药。     

奥硝唑栓联合加替沙星治疗滴虫性阴道炎疗效分析与评价

目的 评价奥硝唑栓联合加替沙星治疗滴虫性阴道炎的有效性.方法 采用随机对照试验设计,治疗组70例采用奥硝唑栓联合加替沙星进行治疗,对照组67例给予甲硝唑治疗.结果 治疗组的总有效率为98.6%,对照组的总有效率为85.1%,两组比较差异有统计学意义.结论 奥硝唑栓联合加替沙星可有效治疗滴虫性阴道炎,且不良反应较少.     

奥硝唑栓联合加替沙星治疗滴虫性阴道炎疗效分析与评价

目的评价奥硝唑栓联合加替沙星治疗滴虫性阴道炎的有效性。方法采用随机对照试验设计,治疗组70例采用奥硝唑栓联合加替沙星进行治疗,对照组67例给予甲硝唑治疗。结果治疗组的总有效率为98.6%,对照组的总有效率为85.1%,两组比较差异有统计学意义。结论奥硝唑栓联合加替沙星可有效治疗滴虫性阴道炎,且不良反应较少。     

4种给药方案治疗滴虫性阴道炎的成本-效果对比研究

目的:探讨4种给药方案治疗滴虫性阴道炎所产生的经济学效果.方法:选择我院门诊滴虫性阴道炎患者120例,随机分为4组,分别给予保妇康栓加奥硝唑片(A组)、双唑泰栓加奥硝唑片(B组)、甲硝唑栓加奥硝唑片(C组)、奥硝唑片(D组),运用药物经济学方法进行成本-效果分析.结果:4组方案成本分别为:116.4元、128.8元、85.1元、63.8元;有效率分别为:90%、93.3%、93.3%、86.6%;成本-效果比分别为:1.29、1.38、0.91、0.73;A、B、C方案相对于D方案的增量成本-效果比分别为:15.4、9.7、3.2.结论:甲硝唑栓加奥硝唑片治疗滴虫性阴道炎疗效好、成本低,并且不良反应最少.     

A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis

Objective:

To compare the cure rates of oral single dose of metronidazole (2 g), tinidazole (2 g), secnidazole (2 g), and ornidazole (1.5 g) in cases of bacterial vaginosis.

Materials and Methods:

This was a prospective, comparative, randomized clinical trial on 344 Indian women (86 women in each group) who attended a gynecology outpatient department with complaint of abnormal vaginal discharge or who had abnormal vaginal discharge on Gynecological examination but they did not complaint of it. For diagnosis and cure rate of bacterial vaginosis, Amsel''s criteria were used. Statistical analysis was done by Chi-square test of proportions. The cure rate was compared considering metronidazole cure rate as gold standard.

Results:

At 1 week, the cure rate of tinidazole and ornidazole was 100% and at 4 weeks, it was 97.7% for both drugs (P<0.001). Secnidazole had cure rate of 80.2% at 4 weeks (P=NS). Metronidazole showed a cure rate of 77.9% at 4 weeks, which is the lowest of all four drugs.

Conclusion:

Tinidazole and ornidazole have better cure rate as compared to metronidazole in cases of bacterial vaginosis.KEY WORDS: Bacterial vaginosis, metronidazole, ornidazole, secnidazole, tinidazole     

4种给药方案治疗滴虫性阴道炎的成本-效果分析

目的探讨4种给药方案治疗滴虫性阴道炎所产生的疗效。方法选择我院门诊滴虫性阴道炎患者200例,随机分为4组,分别给予A组保妇康栓、B组孚舒达栓(复方甲硝唑栓)、C组替硝唑栓、D组奥硝唑胶囊,运用药物经济学方法进行分析。结果A组方案成本最低并且疗效好。结论保妇康栓治疗滴虫性阴道炎不仅疗效好、成本低、不良反应小并且对解决当今临床上抗生素的耐药性问题有积极作用。     

4种给药方案治疗滴虫性阴道炎的药物经济学分析

目的 探讨4种给药方案治疗滴虫怀阴道炎所产生的疗效.方法 选择我院门诊滴虫性阴道炎患者200例,随机分为4组,分别给予A组保妇康栓、B组孚舒达栓(复方甲硝唑栓)、C组定菌生(乳杆菌活菌胶囊)、D组奥硝唑胶囊,运用药物经济学方法进行分析.结果 A组方案成本最低并且疗效好.结论 保妇康栓治疗滴虫性阴道炎不仅疗效好、成本低、副作用小并且对解决当今临床上抗生素的耐药性问题有积极作用.     

Tinidazole for the treatment of vaginal infections

Tinidazole has been used for vaginal infection worldwide but not in the US for > 40 years. Recently, tinidazole has been re-introduced and approved by the FDA for trichomoniasis and restudied as an alternative to metronidazole for bacterial vaginosis. In vitro antimicrobial activity and pharmacokinetics studies indicate that tinidazole has minor but possibly relevant antimicrobial as well as pharmacokinetic advantages when compared directly with metronidazole. Clinical comparison has been infrequent although the limited head-to-head studies indicate minimal therapeutic advantage with tinidazole. Perhaps the more relevant differences relate to the enhanced tolerance and reduced toxicity of tinidazole. Ongoing, as yet incomplete, studies directly comparing the clinical efficacy of metronidazole and tinidazole for bacterial vaginosis should clarify the status of tinidazole; however, cure rates are unlikely to be significantly different. Although uncommon, high-level trichomonal metronidazole resistance can be reliably cured by using tinidazole, which is an invaluable advantage.     

Tinidazole for the treatment of vaginal infections

Tinidazole has been used for vaginal infection worldwide but not in the US for > 40 years. Recently, tinidazole has been re-introduced and approved by the FDA for trichomoniasis and restudied as an alternative to metronidazole for bacterial vaginosis. In vitro antimicrobial activity and pharmacokinetics studies indicate that tinidazole has minor but possibly relevant antimicrobial as well as pharmacokinetic advantages when compared directly with metronidazole. Clinical comparison has been infrequent although the limited head-to-head studies indicate minimal therapeutic advantage with tinidazole. Perhaps the more relevant differences relate to the enhanced tolerance and reduced toxicity of tinidazole. Ongoing, as yet incomplete, studies directly comparing the clinical efficacy of metronidazole and tinidazole for bacterial vaginosis should clarify the status of tinidazole; however, cure rates are unlikely to be significantly different. Although uncommon, high-level trichomonal metronidazole resistance can be reliably cured by using tinidazole, which is an invaluable advantage.     

奥硝唑注射液治疗妇产科厌氧菌感染的临床效果

目的:评价奥硝唑氯化钠注射液治疗妇产科厌氧菌感染的临床疗效及安全性.方法:厌氧菌感染患者94例随机分为2组,试验组静滴奥硝唑氯化钠注射液500mg,bid,对照组静滴甲硝唑氯化钠注射液500mg,bid,疗程5d.结果:试验组和对照组临床治愈率分别为72.3%及66.0%(P>0.05);细菌清除率分别为85.0%及81.0%(P>0.05);不良反应发生率分别为6.4%及8.5%(P>0.05).结论:奥硝唑氯化钠注射液治疗妇产科厌氧菌感染安全有效.     

复方奥硝唑栓的体外抗菌活性研究

目的:研究复方奥硝唑栓的体外抗菌活性。方法:采用试管二倍稀释法测定复方奥硝唑栓对金黄色葡萄球菌、大肠杆菌、粪肠球菌及脆弱拟杆菌的最小抑菌浓度(MIC)和最小杀菌浓度(MBC),并以氧氟沙星栓和替硝唑栓进行对照。结果:复方奥硝唑栓对金黄色葡萄球菌、大肠杆菌、粪肠球菌及脆弱拟杆菌显示很强的抗菌活性,其MIC值分别为0.061、0.015、0.49、0.031μg/ml,MBC值分别为0.12、0.031、0.98、0.031μg/ml。无论是对标准菌株还是临床分离菌株,复方奥硝唑栓MIC、MBC值均明显低于氧氟沙星栓及替硝唑栓,其组方中2组分具有良好的协同作用。结论:复方奥硝唑栓对妇科炎症具有广谱、高效、低毒的特点。