床上体操训练时偏瘫患者的效果观察

目的：观察偏瘫患早期床上训练的效果。方法：对５８例脑血管意外致外偏瘫患随机分成２组：观察组３０例，护理中指导早期床上体操训练：对照组２８例，按常规护理。以上、下肢肌力和日常生活活动能力（ＡＤＬ）为评价指标，于训练开始时、训练４周、训练８周各评价１次。结果：观察训练４周、８周时患侧上肢同力以及ＡＤＬ水平明显增加，与对照组对比有显差异（Ｐ〈０．０１）。患侧下肢肌力训练４周及８周时均增加，与对照组     

癫痫患者T淋巴细胞亚群和泌乳素的测定

为探讨神经内分泌免疫调节功能变化在癫痫发病中的作用，采用放射免疫法和ＡＰＡＡＰ法对４６例癫痫患者和３０例健康对照组血清泌乳素（ＰＲＬ）及外周血Ｔ淋巴细胞亚群进行了检测。结果显示：癫痫患者ＣＤ４细胞及ＣＤ４／ＣＤ８比值明显低于对照组（Ｐ＜００１，Ｐ＜０００１）；ＣＤ８细胞和ＰＲＬ含量显著高于对照组（Ｐ＜０００１，Ｐ＜００１），且上述指标的改变与癫痫的发作频率有关；ＰＲＬ与ＣＤ４／ＣＤ８之间呈显著负相关。提示：神经内分泌免疫调节功能失衡在癫痫的发病机制中起着重要的作用     

烹调油烟接触者外周血T淋巴细胞亚群的调查

目的：了解烹调油烟接触者的免疫状况。方法：采用抗人Ｔ淋巴细胞亚群单克隆抗体ＡＰＡＡＰ桥联酶标法对４４名厨师及３１名服务员外周血Ｔ淋巴细胞亚群进行了测定,同时应用单向免疫扩散法测定了调查者血清抗体滴度。结果：烹调油烟接触者外周血Ｔ淋巴细胞ＣＤ＋３、ＣＤ＋４细胞百分率明显低于对照组（Ｐ＜００１）,ＣＤ＋８细胞百分率明显高于对照组（Ｐ＜００１）,ＣＤ＋４／ＣＤ＋８比值明显低于对照组（Ｐ＜００１）。烹调油烟接触者血清ＩｇＧ抗体滴度明显高于对照组（Ｐ＜００１）。结论：烹调油烟可致细胞免疫功能抑制,体液免疫功能增强     

骨髓增生异常综合征T淋巴细胞亚群的观察

采用单克隆抗体和免疫荧光技术检测２５例骨髓增生异常综合征（ＭＤＳ组）和２０例正常人（对照组）外周血Ｔ淋巴细胞亚群。结果ＭＤＳ组总Ｔ细胞（Ｔ２）百分比和绝对值较对照组均降低（Ｐ＜００１），抑制Ｔ细胞（Ｔ８）百分比和绝对值均增高（Ｐ＜００５），辅助Ｔ细胞（Ｔ４）与Ｔ８比值降低（Ｐ＜００１）而Ｔ４百分比和绝对值无明显差异（Ｐ＞００５），可能与多数患者检测前应用了激素等治疗有关。重度贫血者Ｔ４百分比和Ｔ４／Ｔ８比值较中度贫血者明显降低（Ｐ＜００５），而Ｔ８百分比无明显差异（Ｐ＞００５）。认为Ｔ淋巴细胞亚群的检测是ＭＤＳ患者免疫功能监测的有价值指标     

轮状病毒肠炎患儿免疫功能动态变化及其临床意义

采用透射比浊法和抗体致敏红细胞花环试验检测了３８例生长发育正常的轮状病毒肠炎（ＲＶＥ）患儿血清免疫球蛋白和Ｔ细胞亚群。结果显示：急性期血清ＩｇＧ、ＩｇＡ、ＩｇＭ、ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８比值明显降低于对照组及恢复期（Ｐ＜００１），尤其是ＩｇＡ、ＣＤ４／ＣＤ８比值较对照组降低更为明显（Ｐ＜０００１），ＣＤ８明显高于对照组及恢复期（Ｐ＜００１）。恢复期随着临床症状逐渐消失，ＩｇＧ、ＩｇＡ、ＩｇＭ、ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８比值升高，ＣＤ８降低、并逐渐恢复正常，与对照组之间无显著性差异（Ｐ＞００５）。结果表明：细胞免疫和体液免疫功能参与了ＲＶ的感染过程，ＩｇＡ、ＣＤ４／ＣＤ８比值与疾病的预后有关。     

不同浓度的布比卡因用于硬膜外术后镇痛的临床观察

选择８８例术后患者随机分为４组：Ａ组，生理盐水１０ｍｌ；Ｂ组，０１２５％布比卡因１０ｍｌ，Ｃ组，０１８％布比卡因１０ｍｌ，Ｄ组，０２５％布比卡因１０ｍｌ。于手术结束时一次注入硬膜外腔，观察术后４、８、１２、２４ｈ内镇痛效果。结果：疼痛缓解率（Ⅰ＋Ⅱ级）在８０％以上，完全镇痛率（Ⅰ级）术后８ｈ，Ａ与Ｂ组有显著差异（Ｐ＜００５），Ａ与Ｃ、Ｄ组间有非常显著差异（Ｐ＜００１）。术后强化药使用率：Ａ与Ｃ、Ｂ与Ｄ组间有显著差异（Ｐ＜００５）；Ａ与Ｄ、Ｃ与Ｂ组间有极显著差异（Ｐ＜００１）。根据镇痛效果及强化药使用情况两项结合认为Ｃ组的术后镇痛最佳。     

哮喘,慢支,肺心病患者T淋巴细胞亚群与免疫球蛋白的变化

对３０例过敏性哮喘发作，３４例慢支急性发作期及２３例肺心病急性期患者外周血Ｔ淋巴细胞亚群与免疫球蛋白变化进行观察，并与３０例健康才人作比较。结果显示：哮喘、慢支、肺心病患者外周血ＣＤ３＾＋、ＣＤ４＾＋、ＣＤ８Ｔ细胞均极显著低于正常对照组（Ｐ〈０．０５），Ｐ〈０．０１）；ＣＤ４＾４／ＣＤ８＾＋比值哮喘组极高于对照组（Ｐ〈０．０１），肺心病级极明显低于对照组（Ｐ〈０．０１），慢支级瑟对照组无明显差异（     

卵巢功能早衰患者抗卵巢抗体及细胞免疫功能的测定

目的：探讨卵巢功能早衰（ＰＯＦ）患者细胞免疫功能的变化及其与抗卵巢抗体（ＡＯＡｂ）之间的关系。方法：检测３０例正常妇女（对照组）和３０例ＰＯＦ患者（ＰＯＦ组）的血清ＡＯＡｂ、外周血Ｔ淋巴细胞亚群及对卵巢抗原的白细胞促凝血活性（ＬＰＣＡ）。结果：对照组血清ＡＯＡｂ水平为１．３９±０．７２ｋＵ／Ｌ，ＰＯＦ组血清ＡＯＡｂ水平为６．８０±１．９１ｋＵ／Ｌ，两者比较，差异有极显著性（Ｐ＜０．０１）。与对照组比较，ＰＯＦ组ＣＤ３＋、ＣＤ４＋细胞百分率（分别为６５．４２±５．３１％和４４．７９±５．９０％）明显升高，ＣＤ８＋细胞百分率（２５．６３±４．２６％）明显降低，ＣＤ４＋／ＣＤ８＋比值（１．６６±０．２７）增加（Ｐ＜０．０１）。ＣＤ４＋／ＣＤ８＋比值升高者的ＡＯＡｂ阳性率（８５．７％，１８／２１），明显高于ＣＤ４＋／ＣＤ８＋比值正常者（３／９，Ｐ＜０．０１）。ＡＯＢｂ阳性的ＰＯＦ患者ＬＰＣＡ水平上升，且与ＡＯＡｂ之间有非常显著的相关性（χ２＝８．３７８，Ｐ＜０．０１）。结论：ＰＯＦ患者对卵巢抗原同时产生细胞免疫和体液免疫反应，ＰＯＦ的发病可能与免疫因素有关     

肝癌患者外周血NK和LAK活性及T细胞亚群的变化

采用３ＨＴｄＲ释放法测定了２０例肝癌患者的外周血自然杀伤细胞（ＮＫ）活性及淋巴因子激活的杀伤细胞（ＬＡＫ）活性，同时用ＡＢＣ法检测其外周血Ｔ细胞亚群变化。结果显示，肝癌患者的外周血ＮＫ和ＬＡＫ活性显著低于正常人（Ｐ＜０．０１），Ｔ细胞亚群ＣＤ３及ＣＤ４细胞减少（Ｐ＜０．０１），ＣＤ８细胞增多（Ｐ＜０．０１），ＣＤ４／ＣＤ８比值显著降低（Ｐ＜０．０１）且出现倒置。上述结果提示肝癌患者细胞免疫功能出现紊乱及免疫活性细胞功能有缺陷。     

通脉增智胶囊治疗血管性痴呆的临床观察

应用通脉增智胶囊治疗血管性痴呆（ＶＤ）６４例（治疗组），同时用脑复康治疗ＶＤ患者３２例（对照组），并对其治疗效果进行观察。结果：治疗组总有效率（８２８％）明显高于对照组（５６２％）（Ｐ＜００１）；治疗组长谷川痴呆量表（ＨＤＳ）得分也明显高于治疗前和对照组（Ｐ＜００１）；治疗组患者血浆超氧化物歧化酶（ＳＯＤ）活性较治疗前明显升高（Ｐ＜００５），脂质过氧化物（ＬＰＯ）含量则较治疗前明显降低（Ｐ＜００１）；而对照组患者血浆ＳＯＤ及ＬＰＯ水平，治疗后与治疗前相比均无显著性差异（Ｐ＞００５）。提示：通脉增智胶囊对ＶＤ患者的疗效优于脑复康。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.