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Synthesis of 35 new compounds of α-chloro-β-(5-nitro-2-furyl) acrylamides and 5-[α-chloro-β-(5-nitro-2-furyl ) vinyl]-oxadiazoles by known methods are reported. In preliminary test in mice 10 compounds were found to possess pronounced activity against Schistosomiasis japonica. Among these Ⅰ12, Ⅰ13, Ⅰ14, Ⅰ20, Ⅱ1 and Ⅱ8 were shown to be the most effective. 相似文献
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目的 建立安尔眠胶囊中2,3,5,4’-四羟基二苯乙烯-2-O-β-D-葡萄糖苷(C20H2209)的含量测定方法。方法 采用高效液相色谱(HPLC)法,以Dionex Acclaim 120® C18色谱柱(150 mm×4.6 mm,5 μm)为分离柱,以乙腈-1%甲酸溶液(23:77)为流动相,体积流量1.0 mL/min,检测波长320 nm,柱温25 ℃。结果 2,3,5,4’-四羟基二苯乙烯-2-O-β-D-葡萄糖苷在0.010~0.200 μg呈现良好的线性关系(r=0.999 6),平均回收率为97.35%,RSD为2.07%。结论 该方法<准确可靠,适用于安尔眠胶囊中2,3,5,4’-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的含量测定。 相似文献
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根据5-(对-氟苯氧基)-6-甲氧基-8-(4-氨基-1-甲基-丁氨基)喹啉(Ⅰ1)(表1)对猴疟原虫(Plasmodium cynomolgi)的作用略优于伯喹而毒性较低的报道,合成了化合物Ⅰ1(代号M7844),同时还合成了衍生物5-取代苯氧基-6-甲氧基-8-(4-取代氨基-1-甲基丁氨基)喹啉(Ⅰ3~17)(表1)以及其同分异构体5-取代苯氧基6-甲氧基-8-(5-取代氨基戊氨基)喹啉(Ⅱ13~28)(表2)。药理研究证明化合物Ⅰ1~7、Ⅰ16及Ⅱ18等对鼠疟P.yoelii均有不同程度的作用。化合物Ⅰ1(M7844)的毒性甚低,对小鼠的毒性比磷酸伯喹低20余倍,对家兔的溶血反应也明显低干伯喹。但在相同剂量下,对猴疟P.cynomolgi的作用不及伯喹。对鼠疟红前期的作用比伯喹低4~5倍。 相似文献
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由5(及7)-[双-(β-羥乙基)-氨基]吲(口朶)-2-羧酸乙酯(Ⅶa,b)合成了5(及7)-[双-(β-氯乙基)-氨基]吲(口朶)-2-羧酸乙酯(Ⅱa和Ⅱb)、5(及7)-[双-(β-溴乙基)-氨基]-吲(口朶)-2-羧酸乙酯(Ⅱc和Ⅱd)以及5(及7)-[双-(β-碘乙基)-氨基]-吲(口朶)-2-羧酸乙酯(Ⅱe和Ⅱf)。再經水解制得其相应的羧酸(Ia-f)。此外又合成了5(及7)-乙氧羰氨基-吲(口朶)-2-羧酸乙酯(IXa,b)和5-乙氧基-7-[双-(β-氯乙基)-氨基]-吲(口朶)-2-羧酸乙酯(Ⅶ)。化合物Ia,Ib,Ic,Ⅱa,Ⅱb,Ⅱc,Ⅱe和Ⅱf对組織培养Hela細胞有明显的抑制作用。化合物Ⅰa,Ⅰb,Ⅱa和Ⅱb口服时对小鼠肉瘤180有明显的抑制作用。化合物Ⅰe,Ⅰf和Ⅻ对肉瘤180具有中度的抑制作用。 相似文献
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山野豌豆黄酮类化学成分的研究 总被引:9,自引:0,他引:9
自山野豌豆(Vicia amoena Fisch.)全草的乙醇提取物中分得6个化合物,经波谱和化学分析鉴定其中一个为新的黄酮甙,命名为山野豌豆甙(amoenin A3),其余5个化合物为槲皮素(quercetin D2)、山奈酚(kaempferol D1)、槲皮素-3-O-α-L-鼠李糖甙(quercetin-3-O-α-L-rhamnosideC1)、槲皮素-3-O-β-D-葡萄糖甙(quercetin-3-O-β-D-glucosideC2)、山柰酚-3,7-O-α-L-二鼠李糖甙(kaempferol-3,7-O-α-L-dirhamnoside A2)。以上黄酮类化合物均为首次从山野豌豆中分得。 相似文献
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目的 建立测定通乐颗粒中2, 3, 5, 4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的方法。方法 采用HPLC法,色谱柱为Phenomenex C18柱,检测波长为320 nm,流动相为乙腈-水(20∶80),体积流量为1.0 mL/min。结果 2, 3, 5, 4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷在10~100 μg/mL与峰面积呈良好线性关系(r=0.999 7),平均回收率为99.74%。结论 本方法准确、简便、重复性好,可用于通乐颗粒中2, 3, 5, 4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的含量测定。 相似文献
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川芎有效成份的研究——新的苯酞类化合物4-羟基-3-丁基苯酞的结构测定 总被引:9,自引:0,他引:9
《药学学报》1979,14(11):670-675
从川芎(Ligusticum wallchii Franch)的酚性部分中分离得到一个新的苯酞类化合物Ⅰ,熔点190~191℃,[α]D—105.5°,C12H4O3。化合物Ⅰ的结构经化学和仪器分析测定,鉴定为4-羟基-3-丁基苯酞(4-Hydroxy-3-butyl phthalide),并用合成证实。 相似文献
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Experiments were conducted to study the major constituents of Zingiber officinale responsible for its molluscicidal activity and the effect of the active component on different stages of Schistosoma mansoni. Gingerol and shogaol exhibited potent molluscicidal activity on Biomphalaria glabrata. Gingerol (5.0 ppm) completely abolished the infectivity of Schistosoma mansoni miracidia and cercariae in B. glabrata and mice, respectively, indicating that the molluscicide is capable of interrupting schistosome transmission at a concentration lower than its molluscicidal concentrations. 相似文献
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M M Kady L Brimer P Furu E Lemmich H M Nielsen S T Thiilborg O Thastrup S B Christensen 《Planta medica》1992,58(4):334-337
The molluscicidal principles of Ethulia conyzoides were identified as ethuliacoumarin A (1) and isoethuliacoumarin A (2). Ethuliacoumarin A possessed an LC90 between 19 and 23.5 ppm depending on the age of the snail against Biomphalaria glabrata, and between 12 and 15 ppm against Bulinus truncatus. In addition, ethuliacoumarin A was found to be cercaricidal at 25 ppm and ovicidal. Ethuliacoumarin has the structural requirements considered essential for anticoagulant activity. Consequently the anticoagulant dicumarol (4) was tested and found to be molluscicidal in the range from 2.5 to 10 ppm. In contrast, the coumarin anticoagulant warfarin (3) did not show molluscicidal activity. 相似文献
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The authors experiment molluscicidal properties of Ambrosia maritima L. from Egypt and cultivated in Senegal. Four generations are tested. Six plants, on eight tested, had same molluscicidal activity as the strain in Egypt. 相似文献
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17 diterpenoids isolated from brown algae of the family DICTYOTACEAE have been evaluated for molluscicidal and antifungal activity. Significant molluscicidal activity is exhibited by the two geometrical isomers 9 and 10. The assessment of structure-activity relationships has been considered. 相似文献
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Caroline Keller Marc Maillard Jean Keller Kurt Hostettmann 《Pharmaceutical biology》2013,51(7):518-525
Crude extracts of 57 species of European fungi have been tested for their bactericidal (Bacillus subtilis, Escherichia coli), fungicidal (Candida albicans, Cladosporium cucumerinum), larvicidal (Aedes aegypti), molluscicidal (Biomphalaria glabrata), antioxidant and free-radical scavenging activities. Connatine and 2(3,4-dihydroxyphenyl)glycine, two compounds with antioxidant and free-radical scavenging properties, were subsequently isolated from the methanolic extracts of Lyophyllum connatum (Tricholomataceae) and Cortinarius hercynicus (Cortinariaceae), respectively. In addition, linoleic acid was shown to be molluscicidal. 相似文献
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The aqueous and methanolic extracts of a series of typical tannin containing plants exhibit strong molluscicidal properties against the freshwater snail biomphalaria glabrata, which is the intermediate host of schistosomiasis. The crude extracts of Krameria triandra (Krameriaceae) and Arctostaphylos uvaursi (Ericaceae) were active at concentrations of 50 ppm. Hydrolyzable and condensed tannins are responsable for the molluscicidal activity. This report indicates a new class of plant derived compounds which may have important practical application for the control of schistosomiasis in endemic areas. 相似文献
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The toxicity of the molluscicidal plant, Ambrosia maritima L., has been evaluated in fish, crustacea and algae. The LC50 for fries of the guppy, Lebistes reticulatus, was respectively 650 and 450 mg/litre using a powder or an ether-methanol-hexane extract from the leaves of the plant. This concentration is much higher than the molluscicidal concentration (LC90) of 35 to 70 mg/litre, which is used in the field (irrigation canals in Egypt). Preliminary tests showed that juveniles of L. reticulatus and Tilapia aurea were as sensitive as the fries. Using the same extract of A. maritima the LC50 for Daphnia magna was 766 mg/litre and no toxic effects could be observed in algae Selenastrum capricornutum at 1 g/litre. It can be concluded that A. maritima has a very low toxicity to aquatic non-target organisms. It is not toxic when used at the molluscicidal concentration of 35 to 70 mg/litre. 相似文献
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Ayoub SM 《Planta medica》1982,46(3):181-183
The acetone, alcohol and aqueous extracts of fruits of Acacia nilotica (L) Willd. ex Del. (Mimosaceae) showed molluscicidal activity against Bulinus truncatus and Biomphalaria pfeifferi, the two snail species which transmit schistosomiasis in the Sudan (S. haematobium and S. mansonii). TAN, a new vegetable molluscicide prepared from the aqueous extract of the fruits of A. nilotica was produced on a pilot scale by using the spray drying procedure. Due to the high content of tannins in the powder (more than 56%), the molluscicidal properties of this plant may well be due to these compounds. 相似文献
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S M Ayoub 《Planta medica》1982,46(11):181-183
The acetone, alcohol and aqueous extracts of fruits of ACACIA NILOTICA (L) W ILLD. ex D EL. (Mimosaceae) showed molluscicidal activity against BULINUS TRUNCATUS and BIOMPHALARIA PFEIFFERI, the two snail species which transmit schistosomiasis in the Sudan (S. haematobium and S. mansonii). TAN, a new vegetable molluscicide prepared from the aqueous extract of the fruits of A. NILOTICA was produced on a pilot scale by using the spray drying procedure. Due to the high content of tannins in the powder (more than 56%), the molluscicidal properties of this plant may well be due to these compounds. 相似文献