肿瘤患者合并弓形虫感染血清抗体检测分析

目的　了解银川地区肿瘤患者弓形虫感染状况 ,使肿瘤合并弓形虫感染时能得到及时的治疗 ,提高化疗或放疗的效果。方法　用间接血凝法 (IHA)对 2 32例各种肿瘤患者及 2 6 0名正常体检者血清进行检测。结果2 32名肿瘤患者弓形虫血清抗体阳性 2 4人 ,阳性率为 10 .34 % ,2 6 0名正常体检者弓形虫血清阳性 4人 ,阳性率为1.5 4% ,抗体几何平均滴度 (GMT)分别为 11.6 5和 1.5 4。结论　肿瘤患者弓形虫感染率及血清抗体平均滴度均高于正常体检者 ,两者间有显著性差异 (P <0 .0 1)。     

不孕症夫妇弓形虫感染检测

目的:检测弓形虫在不孕不育夫妇的感染情况。方法:采用ELISA方法检测患者血清弓形虫CAg、IgMI、gG。结果:CAgI、gMI、gG阳性率分别为9.09%、16.67%、25.00%;弓形虫抗体阳性率为37.12%;弓形虫感染率为37.88%;男、女性弓形虫感染率分别为22.73%、53.03%,男女弓形虫感染率有显著性差异。夫妻双方同时感染的阳性率为15.15%;习惯性流产患者弓形虫感染率为60%。结论:弓形虫感染在不孕不育夫妇中较常见,女性感染率高于男性;习惯性流产患者感染率最高;因此要高度重视并及时治疗弓形虫感染。     

银川市732名大学新生血清弓形虫抗体检测分析

为了解银川地区在校大学生弓形虫感染状况及其与民族、性别、家庭职业之间的关系 ,以保障在校大学生的身体健康 ,用间接血凝试验 (IHA)对 732名入院新生静脉血进行弓形虫抗体检测。结果 ,弓形虫血清抗体阳性率 2 0 5 % ( 1 5 /732 ) ;男、女学生弓形虫抗体阳性率分别为 3 0 8% ( 1 1 /35 7)和 1 0 7% ( 4 /375 ) ,两组间差异无显著性 (P >0 0 5 )。汉、回、满族学生弓形虫抗体阳性率分别为 2 5 1 % ( 1 1 /4 38)、1 84 % ( 3/1 6 3)和 0 79% ( 1 /1 2 6 ) ,各组间差异无显著性 (P >0 0 5 )。农业学生与非农业学生弓形虫抗体阳性率分别为 3 5 1 % ( 1 2 /34 2 )和 0 77% ( 3/390 ) ,两组间有显著性差异 (P <0 0 5 )。显示不同性别和民族的学生均有机会感染弓形虫 ,农业家庭学生弓形虫感染率高于非农业家庭学生。     

不孕不育人群弓形虫IgM抗体检测及结果分析

目的 探讨不孕不育人群弓形虫近期感染情况.方法 采集不孕不育人群血清并低温保存,用酶联免疫吸附试验检测血清中IgM抗体.结果 1 411 例不孕不育患者IgM阳性127例,阳性率9.001%.其中男性206例,IgM阳性11例,阳性率5.340%;女性1 205例,IgM阳性116人,阳性率9.627%.115对夫妇中男、女性弓形虫IgM抗体阳性率分别为6.957%和19.13%.男女弓形虫感染率有显著性差异.结论 弓形虫在不孕不育人群中存在较高感染率,女性感染率高于男性,因此应高度重视并治疗弓形虫感染.     

血液病患者弓形虫感染情况调查

目的 :探讨血液病与弓形虫感染的关系。方法 :采用间接血凝试验 (IHA)与酶联免疫吸附试验 (ELISA)对 6 2例各种血液病患者血清中的弓形虫抗体进行检测 ,并用IHA检测对照组中 85例医院职工、118例献血员、5 8例急性感染性疾病患者及 84例慢性肝病患者血清中的弓形虫抗体。结果 :各种血液病患者IHA阳性率为 2 5 .81% ,ELISA阳性率为 2 9.0 3%。IHA检测医院职工的阳性率为 2 .35 % ,献血员为 2 .5 4 % ,急性感染性疾病为 1.72 % ,慢性肝病为 3.5 7% ,均明显低于血液病患者的阳性率。结论 :血液病患者容易并发弓形虫感染 ,临床上应对此引起高度重视。     

弓形虫感染与儿童先天性疾病的研究

用IHA法检测患先天性疾病儿童147例,患一般疾病儿童396例和健康儿童150例血清弓形虫抗体。结果阳性率分别为21.08%,3.53%和2.00%。患先天性疾病儿童弓形虫抗体阳性率显著高于一般疾病和健康儿童,P<0.001,差异非常显著。提示弓形虫感染可引起儿童先天性疾病或畸形。     

弓形虫感染对病毒性肝炎预后影响的初步调查

目的:调查病毒性肝炎患者中弓形虫感染情况及弓形虫感染对病毒性肝炎预后的影响。方法:对92例住院的病毒性肝炎患者采用间接血凝(IHA)方法检测弓形虫抗体,同时应用ELISA法进行弓形虫抗体IgM、IgG检测。结果:92例病毒性肝炎中4例IgM和IgG同时阳性,2例IHA1∶64,同时IgM,总感染率为6.25％。在AVH、CVH、HG、HCC中,弓形虫感染率分别为2.86％、5.26％、9.05％、16.70％、50％,其感染率随肝炎病程加重而升高。合并弓形虫感染可导致肝损害加重,其中总胆红素升高明显,与急、慢性肝炎、肝硬化相比明显增高(P<0.05)。而ALT值与慢性肝炎和肝硬化相比差异显著(P<0.01)。结论:弓形虫感染可加重病毒性肝炎的病程,延长肝功能恢复时间。     

精神分裂症患者弓形虫感染的血清学调查

目的：了解张家口地区精神分裂症患者弓形虫感染状况，探讨弓形虫感染与精神分裂症之间的关系。方法：采用间接红细胞凝集试验对222例住院精神分裂症患者及78例健康体检者进行弓形虫抗体检测。结果：张家口地区精神分裂症患者患者弓形虫抗体阳性率为7．66％，健康体检查为1．28％，两者之间差异显著（P＜0．05），结论：本地区精神分裂症患者弓形虫抗体阳性率高于健康人群，提示临床医务工作者应加强对弓形虫病的认识，重视精神病患者的弓形虫感染情况，对门诊和住院病人进行常规弓形虫检测。     

2005年湛江市、韶关市、汕头市人兽弓形虫感染状况调查

目的 了解广东省湛江市、韶关市、汕头市的人兽弓形虫感染情况.方法 收集3个地区人、猪、鼠血清,采用酶联免疫吸附试验(ELISA)间接法检测弓形虫IgG抗体.结果 湛江市检测猪血清279份,阳性13份,阳性率为4.66%,检测鼠血清93份,阳性7份,阳性率7.53%;韶关市检测人血清42份,阳性0份,检测鼠血清95份,阳性3份,阳性率3.16%;汕头市检测人血清50份,阳性6份,阳性率为12.00%,检测鼠血清100份,阳性3份,阳性率为4.00%.结论 汕头市人群存在弓形虫感染,湛江市、韶关市、汕头市兽类存在弓形虫感染,3个地区的鼠类弓形虫感染率无统计学意义,家鼠、野鼠的弓形虫感染率也无统计学意义.     

弓形虫感染精神分裂症患者临床及血液流变学观察

目的 了解弓形虫感染的精神分裂症患者在临床上和血液流变学指标上的变化，探讨弓形虫感染与精神分裂症的关系。方法 采用酶联免疫吸附法（ELISA）检测145例精神分裂症患者的血清弓形虫抗体水平，并测定血液流变12项指标、评定BPRS、SAPS、SANS。然后。按弓形虫抗体阳性和阴性进行分组比较。结果 精神分裂症患者弓形虫抗体阳性率为13．1％；两组患者的BPRS总分、SANS总分、SAPS总分差异均无显著（P〉0．05），但BPRS中的激活性和敌对猜疑因子分阳性组显著高于阴性组（P〈0．01和P〈0．05）；弓形虫抗体阳性组患者呈高粘滞低脑血流量的血液流变学特点，红细胞压积、电泳时间、电脉率等两组间差异无显著性（P〉0．05）。结论 弓形虫抗体阳性和阴性患者存在某些类似的临床特点和血液流变学特性，但也各有其特点，揭示弓形虫感染可能与精神分裂症的发病有关。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.