焦虑或抑郁情绪对原发性高血压患者血栓前状态的影响

目的：观察焦虑或抑郁情绪对原发性高血压患者血栓前状态的影响。方法：112高血压病患者被均分为高血压合并焦虑或抑郁组（EH＋A／D组）和单纯高血压组（EH组），测定两组病人血清CD62P、血管假性血友病因子（vWF）、组织型纤溶酶原激活剂（t．PA）、组织型纤溶酶原激活剂抑制剂（PAI-1）、内皮素（ET）．1等血栓前状态指标水平。结果：与EH组比较，EH＋A／D组CD62P[（4．52±2．01）％比（8．38±1．96）％]、vWF[（155．28±23．11）％比（185．23±22．21）％]、PAI-1[（54．35±13．21）ng／L比（79．88±14．53）ng／L]、ET-1r（121．56±33．32）ng／L比（152．78±30．23）ng／L]水平明显升高（P均〈0．05），而t-PA[（19．37土11．46）ng／L比（9．56±8．32）ng／L]水平明显降低（P〈0．05）。结论：焦虑或抑郁情绪会通过激活血小板、影响血管内皮功能及纤溶系统的失衡，加重原发性高血压患者血栓前状态。

Influence of anxiety or depression on prethrombotic state in patientswith essential hypertension

Objective： To observe influence of anxiety or depression on prethrombotic state in patients with essential hypertension （EH）. Methods： A total of 112 EH patients were equally divided into EH＋A/D group and pure EH group. Levels of prethrombotic state indicators, including serum CD62P, von Willebrand factor （vWF）, tissue type plasminogen activator （t-PA）, plasminogen activator inhibitor （PAD -1 and endothelin （ET） -1 were measured in two groups. Results： Compared with pure EH group, there were significant increase in levels of CD62P [ （4. 52＋ 2.01） % vs. （8. 384-1.96） %], vWF [（155. 28±23.11） % vs. （185.23±22.21） %], PAI-1 [（54.35±13.21） ng/ L vs. （79.88±14.53） ng/L] and ET-1 [（121.56＋33.32） ng/L vs. （152.78±30.23） ng/L], P〈0.05 all; and sig- nificant decrease in t-PA level [（19. 37±1.46） ng/L vs. （9. 56±8.32） ng/L, P〈0.05] in EH4-A/D group. Con- clusion： Anxiety or depression can aggravate prethrombotic state of patients with essential hypertension through ac- tivation of platelets, influencing vascular endothelial function and fibrinolytic system imbalance.