肝癌家庭成员HBV、HCV感染的调查分析

目的：通过调查HCC家庭成员HBV、HCV感染状况，探讨HCC的发生与HBV、HCV感染的关系。方法：应用ELISA法和PCR法，分别检测了HCC病例与对照家庭成员血清中HBsAg，抗－HBs,HBeAg，抗－HBe,抗－HBc，抗－HCV 及HBV DNA。结果：病例组子女的HBsAg，抗－HBe，抗－HBc和HBV总感染率均高于对照组，具有统计学意义（P＜0．05或P＜0．01）；且病例组子女HBV DNA检测高于对照组（P＜0．05），HBeAg和HBV DNA密切相关，HBeAg阳性血清HBV DNA检测均为阳性，抗－HCV在病例与对照组间均无显著性差异（P＞0．05）。进入条件Logistic回归方程中的因素为HBsA抗－HBc，其OR值分别为27．96和4．77。结论：HCC家内有HBV感染的聚集性倾向，HBsAg和抗－HBc两项标记，在HCC家庭成员乙肝感染中更具代表性，密切生活接触也是HBV感染传播途径之一，丙肝感染不占主要地位。

Survey and Analysis on HBV and HCV Infection of Families of HCC

Objective In order to investigate infection status about HBV and HCV in family members of HCC and to reveal the opportunity exposed to HBV and HCV infection.Methods HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc,anti-HCV were detected in the sera of family members from case and control using ELISA,and HBV DNA with PCR.Results HBsAg,anti-HBe,anti-HBc and HBV total infection ratio were higher in the children of case group than that in control;anti-HBc and HBV total infection ratio in the spouse of case group were also higher than that in control.Statistical variations were significant(P<0.05 or P<0.01).The examination of HBV DNA in the children of case group was higher than that in control(P<0.05).There was a close connection between HBeAg and HBV DNA.Positive HBV DNA were with positive sera of HBeAg.There was no statistical variation between case and control in anti-HCV(P>0.05).HBsAg and anti-HBc were led into conditional logistic regression equation with odds ratio value of 27.96,4.77 respectively.Conclusion There was a trend of clustering of HBV infection in families of HCC.HBsAg and anti-HBc were representitive markers in Hepatitis B virus infection in the family members of HCC.Close living contact was also one of the routes of transmission.HCV infection wasn't the major type of infection.