| 微波消融治疗不宜手术切除继发性甲状旁腺功能亢进临床效果 |
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| 引用本文： | 曹晓静,霍胜男,彭丽丽,魏莹,赵朕龙,尹琳,李妍,于明安. 微波消融治疗不宜手术切除继发性甲状旁腺功能亢进临床效果[J]. 中国介入影像与治疗学, 2020, 17(3): 145-148 |
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| 作者姓名： | 曹晓静 霍胜男 彭丽丽 魏莹 赵朕龙 尹琳 李妍 于明安 |
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| 作者单位： | 中日友好医院介入超声医学科, 北京 100029,邯郸钢铁集团有限责任公司职工医院甲状腺科, 河北 邯郸 056001,中日友好医院介入超声医学科, 北京 100029,中日友好医院介入超声医学科, 北京 100029,中日友好医院介入超声医学科, 北京 100029,中日友好医院介入超声医学科, 北京 100029,中日友好医院介入超声医学科, 北京 100029,中日友好医院介入超声医学科, 北京 100029 |
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| 基金项目： | 首都临床特色应用研究项目（Z181100001718135）、北京化工大学-中日友好医院生物医学转化工程研究中心2018年度联合基金项目（PYBZ1804）。 |
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| 摘 要： | 目的观察微波消融(MWA)治疗不宜手术切除继发性甲状旁腺功能亢进症(SHPT)患者的有效性及安全性。方法回顾性分析51例接受MWA治疗的SHPT患者,对比消融前后单个增生结节最大径及血清全段甲状旁腺素(iPTH)、钙和磷水平,统计随访期间并发症、局部复发率及新发率。结果51例SHPT共83枚甲状旁腺增生结节均一次性完全消融。消融后3、6个月及随访结束时,单个增生结节最大径均较消融前缩小(P均<0.05),血清iPTH、钙、磷水平均低于消融前(P<0.05)。随访期间9例(9/51,17.65%)发生与MWA相关的轻微并发症,无严重并发症。随访结束时,局部复发率为5.88%(3/51),新发率7.84%(4/51)。结论MWA用于治疗不宜手术切除SHPT安全有效。
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| 关 键 词： | 甲状旁腺功能亢进症,继发性 超声检查 微波消融 |
| 收稿时间： | 2019-08-30 |
| 修稿时间： | 2020-01-07 |
Clinical efficacy of microwave ablation in treatment of secondary hyperparathyroidism ineligible for surgical resection |
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| CAO Xiaojing,HUO Shengnan,PENG Lili,WEI Ying,ZHAO Zhenlong,YIN Lin,LI Yan and YU Ming''an. Clinical efficacy of microwave ablation in treatment of secondary hyperparathyroidism ineligible for surgical resection[J]. Chinese Journal of Interventional Imaging and Therapy, 2020, 17(3): 145-148 |
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| Authors: | CAO Xiaojing HUO Shengnan PENG Lili WEI Ying ZHAO Zhenlong YIN Lin LI Yan YU Ming''an |
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| Affiliation: | Department of Interventional Ultrasound, China-Japan Friendship Hospital, Beijing 100029, China,Department of Thyroid, Hebei Handan Iron and Steel Group Co., Ltd. Staff and Workers Hospital, Handan 056001, China,Department of Interventional Ultrasound, China-Japan Friendship Hospital, Beijing 100029, China,Department of Interventional Ultrasound, China-Japan Friendship Hospital, Beijing 100029, China,Department of Interventional Ultrasound, China-Japan Friendship Hospital, Beijing 100029, China,Department of Interventional Ultrasound, China-Japan Friendship Hospital, Beijing 100029, China,Department of Interventional Ultrasound, China-Japan Friendship Hospital, Beijing 100029, China and Department of Interventional Ultrasound, China-Japan Friendship Hospital, Beijing 100029, China |
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| Abstract: | Objective To observe the efficacy and safety of microwave ablation (MWA) in treatment of secondary hyperparathyroidism (SHPT) ineligible for surgical resection. Methods Clinical data of 51 patients with SHPT ineligible for surgical resection who underwent MWA were retrospectively analyzed. The maximum diameter of single proliferative nodule, serum intact parathyroid hormone (iPTH), calcium and phosphorus were assessed and compared before and after ablation. The complications, local recurrence rate and new incidence rate were counted during follow-up. Results Totally 83 parathyroid hyperplasia nodules in 51 SHPT patients were completely ablated at one time. Three, 6 months after MWA and at the end of the follow-up, the maximum diameter of single proliferative nodule was all smaller than that before MWA (all P<0.05), and serum iPTH, calcium, and phosphorus levels were all lower than that before MWA (all P<0.05). During follow-up, 9 patients (9/51, 17.65%) had minor complications related to MWA, while no serious complication occurred. At the end of follow-up, the local recurrence rate was 5.88% (3/51) and the new incidence rate was 7.84% (4/51). Conclusion MWA is safe and effective in treatment of SHPT ineligible for surgical resection. |
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| Keywords: | hyperparathyroidism, secondary ultrasonography microwave ablation |
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