成都市献血员HCV感染的家庭聚集性研究

目的　分析丙肝病毒(HCV)感染存在家庭聚集现象,以及在排除影响因素的混杂效应下,HCV感染存在家庭聚集现象的可能性。方法　在成都市血液中心收集1997- 10 / 1998- 10献血员名单,采取分层整群抽样方法确定献血员,应用分层分析研究混杂效应。结果　抗-HCV阳性献血员的家庭成员的抗-HCV阳性率(18 .4 9% )高于抗-HCV阴性献血员的家庭成员(7 4 .2 % )。在排除家庭成员的献血史、家庭外丙肝接触史的混杂效应下,家庭内丙肝接触史与HCV家庭聚集有关,有家庭内接触丙肝史者感染HCV的危险更大。结论　研究结果提示HCV在家庭内的传播可能有夫妇间、母亲与子女、父亲与子女及其他方式。

Study on Familial Clustering of HCV Infection among Blood Donors in Chengdu

Objective This study took familial members of blood donors as objects, and analyzed the probability that HCV occurred the familial clustering besides the confounding effect of influential factors. Method 829 blood donors form Chengdu blood transfusion center during Oct 1997-Oct 1998 was collected by stratified cluster sampling, and studied the confounding effect with stratified analysis. Result The anti-HCV seropositive rate (18.94%) of anti-HCV ( )donors familial members was higher than that (7.42%) of anti-HCV (-) donors familial members. Excluding the confounding effects such as the blood donation history of familial members and the contact history outside the family, the contact history inside the family was related to the HCV familial clustering. Conclusion This study prompted HCV was likely to be transmitted through couples, mother and children, father and children, and else methods.