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11.
Na M Min BS An RB Jin W Kim YH Song KS Seong YH Bae K 《Phytotherapy research : PTR》2004,18(12):1000-1004
The EtOH extract from the rhizomes of Astilbe chinensis (Saxifragaceae) exhibited potent antioxidant activity in preliminary screening. Since oxidative stress is known to be involved in the inflammatory response after UVB exposure, the ability of an A. chinensis extract to inhibit UVB-induced PGE2 and NO production was examined. UVB irradiation (35 mJ/cm2) increased PGE2 and NO production, which were significantly decreased by pre-administration of the extract in a dose-dependent manner. The A. chinensis extract also preserved the cellular antioxidant capacity after UVB irradiation, which was determined by the GSH content. UVB irradiation enhanced the formation of ROS in the keratinocytes, which was determined using DCFH-DA, a redox sensitive dye. The levels of intracellular ROS were also significantly reduced by pre-treatment of the extract in a dose-dependent manner measured 9 h after UVB irradiation. The results suggest that the A. chinensis extract may have a protective effect on the UVB-injured keratinocytes by inhibiting PGE2 and NO production, possibly through the inhibition of intracellular ROS accumulation. 相似文献
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Hitomi Sakai Rie Kakuda Yasunori Yaoita Masao Kikuchi 《Journal of natural medicines》2007,61(2):226-228
Seven secoiridoid glycosides, secologanin dimethyl acetal (1), n-butyl vogeloside (2), n-butyl epi-vogeloside (3), (7R)-n-butyl morroniside (4), hydrangenoside A (5), hydrangenoside C (6), and hydrangenoside A dimethyl acetal (7), have been isolated from the leaves of Hydrangea macrophylla subsp. serrata (Thunb.) Makino (Saxifragaceae). The structures were elucidated on the basis of spectral data. 相似文献
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Bioassay-guided fractionation of the rhizomes of Astilbe chinensis afforded four cytotoxic pentacyclic triterpenoids, 3β-hydroxy-olean-12-en-27-oic acid (1), 3β,6β-dihydroxy-olean-12-en-27-oic acid (2), 3β-acetoxy-olean-12-en-27-oic acid (3), and 3β-hydroxy-urs-12-en-27-oic acid (4). The isolation and purification of these compounds was conducted with the application of column chromatography. Their structures were elucidated on the basis of chemical and spectral evidence. 2D NMR techniques including 1H-1H COSY, HMQC, HMBC spectra and HREIMS were extensively applied to establish the structures. Compounds 1–4 showed cytotoxic activities against HO-8910, Hela and HL60 in vitro; moreover, compound 1 induced apoptotic cell death of the HO-8910 in a dose-dependent manner, ranging from 2.5 to 40.0 μg/ml. The presence of these active compounds may be responsible, at least in part, for the antineoplastic action of the traditional crude drug Rhizoma Astilbe chinensis. 相似文献
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八仙花叶化学成分研究 总被引:1,自引:0,他引:1
目的:对中草药八仙花叶的化学成分进行研究.方法:采用硅胶柱色谱、ODS柱色谱和HPLC等手段进行分离纯化,并通过1H,13C-NMR,MS等波谱方法鉴定结构.结果:分离鉴定了11个化合物,包括三萜类3个,分别为泽屋萜(1),白桦脂醇(2),白桦脂酸(3);含氮类化合物6个,分别为2-乙基-3-甲基-马来酰亚胺-N-β-D-葡萄糖苷(4),尿嘧啶核苷(5),胸腺核苷(6),阿糖腺苷(7),烟酰胺(8),焦谷氨酸甲酯(9);异香豆素类2个,分别为绣球酚(10),绣球酚-4’-O-β-D-葡萄糖苷(11).结论:化合物1~4和7~9为首次从该属植物中分离得到. 相似文献
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Seven flavonoids (1–7), two triterpenoids (8 and 9) and four steroids (10, 11, 12 and 13) were isolated from the whole plant of Tiarella polyphylla. Based on the physicochemical and spectroscopic analyses, their structures were identified as myricetin (1), astragalin (2), afzelin (3), quercitrin (4), myricitin (5), nicotiflorin (6), isoquercitrin (7), tiarellic acid (8), 3β-hydroxy-20(29)lupen-27-oic acid (9), β-sitosterol-3-O-β-D-glucoside (10), stigmasterol-3-O-β-D-glucoside (11), β-sitosterol (12) and ergosterol endoperoxide (13). All 13 compounds, with the exception of tiarellic acid were isolated for the first time from T. polyphylla. In the anti-complementary assay, the steroids (12 and 13) exhibited potent activities; whereas, the flavonoids (1 to 7) showed weak or no activities, but even the triterpenoids (8 and 9) and steroidal saponins (10 and 11) evoked hemolysis. 相似文献