重组促卵泡素水针剂通过Ⅲ期临床试验

随着人类寿命的延长, 骨质疏松患者明显增多,严重影响老年人的生活质量。骨质疏松是指单位体积内骨组织包括有机物和无机物的绝对减少,从而导致骨强度降低,骨脆性增加的一组疾病。由于骨量丢失是个渐进过程,不易察觉,且一旦发生骨质疏松便不可恢复,因此需要灵敏、特异的指标来提示早期骨吸收,从而尽早采取有效措施进行预防治疗。骨质疏松的生化指标研究历史较长,早期发现的指标存在缺点,寻找新的骨代谢指标成为近几年的研究热点。     

脑梗塞中代谢综合征的调查

选择脑梗塞患者127例,作OGTT,FPG≥7.8mmol/L,用100g馒头餐法,FPG<7.8mmol/L,用75g葡萄糖法.同时测定血脂、身高、体重、腰围(W)及臀围(H)、血压、肝肾功能等.结果脑梗塞患者中代谢综合征的患病率为42%,而糖尿病、糖调节受损、肥胖、高血压、高甘油三脂(TG)和低高密度脂蛋白胆固醇(HDL-C)的标化患病率分别为46%、25%、30%、90%、26%和5%.结论代谢综合征是脑梗塞的高危因素.     

抚平岁月皱纹 绽放青春光彩

随着人们生活水平的提高,在告别温饱之后,又开始把目光聚焦在提高生存质量上,不仅希望能健康的活到一百岁, 而且还希望活的年轻、漂亮。特别是全天下的女士们,无论她们的生活背景、国籍、肤色、年龄有多么大的差异,她们却有一个共同的梦想:希望永远拥有年轻美丽的肌肤。她们精心妆扮着人生的每个阶段,竭尽全力与面容上的皱纹、色斑、白发抗争着,不停地寻找能够令容颜焕发青春的灵丹妙药。     

夏季六节气饮食进补的基本原则

夏季六节气,一方面机体营养素消耗增加;另一方面,天热大量出汗,又导致了许多营养素从汗液流失。不仅如此,夏季六节气人们的食欲减低和消化吸收不良又限制了营养素的正常摄取,所有     

喝白开水的神奇效果——《水是最好的药》学习笔记

反射疗法要求足部按摩后半小时内要喝一杯(300～500ml)温开水,我过去的认识是:喝水是为了利尿、出汗,因为按摩促进了血液循环,将许多代谢废物和有害物质送到肺、肾、皮肤,喝水有助于将这些垃圾迅速排出体外,按     

PCOS的脂类代谢异常研究进展

多囊卵巢综合征病人常出现不同程度的代谢紊乱,其中脂类代谢异常明显,临床上肥胖、胰岛素抵抗为多见。远期子宫内膜癌、2型糖尿病、心血管疾病的风险增加2～5倍。本综述对其相关性做以具体分析。     

乳腺良性增生32例雌、孕激素受体表达分析

2006—04／2007—04我院经手术切除、病理确诊的乳腺良性增生病患者的石蜡包埋组织标本（均为女性）32例，采用免疫组化的方法观察病变组织中性激素受体的表达，并从组织病理学的角度探讨雌激素受体和孕激素受体在乳腺良性病变组织中的表达和意义。     

Influence of moderate hypothermia on cerebral oxygenation in pigs with intracranial hypertension

BACKGROUND: Moderate hypothermia is one of the effective therapeutic methods for head injury in recent years, there are many mechanisms of moderate hypothermia for brain protection, and its influence on cerebral oxygenation is also one of them. OBJECTIVE: To observe the influence of moderate hypothermia on cerebral oxygenation of animals with acute intracranial hypertension, and further investigate the protective mechanism of moderate hypothermia. DESIGN: A randomized controlled trial. SETTING: Department of Neurosurgery, Renji Hospital affiliated to the Medical College of Shanghai Jiao Tong University. MATERIALS: Twenty healthy little pigs, either male or female, weighing 4.5–5.5 kg, were used. Neurotrend-typed multiparameter monitoring system (Diametrics Company, British); CMA/100 micro-injection pump (Carnegie Company, Sweden). METHODS: The experiment was conducted in the Changzheng Hospital affiliated to the Second Military Medical University of Chinese PLA in November, 2001. The pigs were randomized into two groups: the normothermia group (control group, n =10) and moderate hypothermia group (n =10). ① Bilateral femoral arteries were separated, one was connected to pressometer for monitoring mean arterial pressure (MEP), and the other for analysis of blood gases [including peripheral blood pH value, arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of carbon dioxide (PaCO2), HCO3–]. ② Rectal temperature was monitored with mercurial thermometer. ③ Intracranial pressure was monitored using Camino optic ICP probe placed in the subdural space. ④ Neurotrend multiparameter monitoring sensor was inserted into the white matter for about 4 cm to determine cerebral perfusion pressure (CPP, CPP=MAP(ICP), brain tissue partial oxygen pressure (PO2), partial pressure of carbon dioxide (PCO2), HCO3– and brain temperature. The rectal temperature of animals in the moderate hypothermia group was lowered to 34 ℃ using ice bags, and the body temperature was maintained at 33–35 ℃ for 2 hours. The changes of the parameters were observed continuously, and the pigs in the normothermia group were not treated with cooling. MAIN OUTCOME MEASURES: ① MAP, ICP, rectal temperature, CCP; Indexes of cerebral oxygenation detected with Neurotrend-typed multiparameter monitoring system; ② Results of blood gases analysis in the moderate hypothermia group. RESULTS: All the 20 pigs were involved in the analysis of results. ① MAP, ICP, rectal temperature, CCP and indexes of cerebral oxygenation: In the moderate hypothermia group, the ICP after cooling was obviously lower than that before cooling [(3.31±1.19), (5.33±0.95) kPa, P < 0.05], CCP was higher, brain tissue PCO2 [(12.03±1.73), (10.59±2.01) kPa, P < 0.05], and brain tissue pH value was higher [(7.03±1.63), (9.40±1.30) kPa, P < 0.05], whereas the brain temperature was decreased as compared with that before cooling [(34.9±0.3), (37.2±0.2) ℃, P < 0.05]. ② Results of blood gases analysis in the moderate hypothermia group: There were no significant differences in the parameters of peripheral arterial blood gases analysis before and after cooling in the moderate hypothermia group (P > 0.05) CONCLUSION: Moderate hypothermia will not impair the cerebral oxygenation, and it can reduce brain tissue CO2 and decrease brain tissue acidosis.