全文获取类型
收费全文 | 190311篇 |
免费 | 16792篇 |
国内免费 | 12424篇 |
专业分类
耳鼻咽喉 | 1518篇 |
儿科学 | 2299篇 |
妇产科学 | 2683篇 |
基础医学 | 20012篇 |
口腔科学 | 3235篇 |
临床医学 | 24010篇 |
内科学 | 28086篇 |
皮肤病学 | 1889篇 |
神经病学 | 9207篇 |
特种医学 | 7132篇 |
外国民族医学 | 87篇 |
外科学 | 20278篇 |
综合类 | 34691篇 |
现状与发展 | 39篇 |
一般理论 | 8篇 |
预防医学 | 13710篇 |
眼科学 | 4932篇 |
药学 | 19727篇 |
177篇 | |
中国医学 | 10763篇 |
肿瘤学 | 15044篇 |
出版年
2024年 | 551篇 |
2023年 | 2476篇 |
2022年 | 6412篇 |
2021年 | 8086篇 |
2020年 | 6120篇 |
2019年 | 5536篇 |
2018年 | 5646篇 |
2017年 | 5424篇 |
2016年 | 5019篇 |
2015年 | 7781篇 |
2014年 | 9863篇 |
2013年 | 9880篇 |
2012年 | 14203篇 |
2011年 | 15436篇 |
2010年 | 10538篇 |
2009年 | 8808篇 |
2008年 | 10982篇 |
2007年 | 10886篇 |
2006年 | 10565篇 |
2005年 | 9941篇 |
2004年 | 7459篇 |
2003年 | 7524篇 |
2002年 | 6318篇 |
2001年 | 5337篇 |
2000年 | 4751篇 |
1999年 | 4278篇 |
1998年 | 2683篇 |
1997年 | 2604篇 |
1996年 | 1871篇 |
1995年 | 1718篇 |
1994年 | 1520篇 |
1993年 | 955篇 |
1992年 | 1341篇 |
1991年 | 1184篇 |
1990年 | 1022篇 |
1989年 | 891篇 |
1988年 | 758篇 |
1987年 | 712篇 |
1986年 | 533篇 |
1985年 | 478篇 |
1984年 | 260篇 |
1983年 | 181篇 |
1982年 | 129篇 |
1981年 | 120篇 |
1980年 | 76篇 |
1979年 | 124篇 |
1978年 | 59篇 |
1976年 | 52篇 |
1975年 | 55篇 |
1974年 | 65篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
82.
Matthew D. Li Katrina F. Chu Allegra DePietro Vincent Wu Eric Wehrenberg-Klee Omar Zurkiya Raymond W. Liu Suvranu Ganguli 《Journal of vascular and interventional radiology : JVIR》2019,30(3):314-319
Purpose
To evaluate the feasibility of a same-day yttrium-90 (90Y) radioembolization protocol with resin microspheres (including pretreatment angiography, lung shunt fraction [LSF] determination, and radioembolization) for the treatment of hepatocellular carcinoma (HCC) and liver metastases.Materials and Methods
All same-day radioembolization procedures performed over 1 y (February 2017 to January 2018) were included in this single-institutional retrospective analysis, in which 34 procedures were performed in 26 patients (median age, 63 y; 13 women), 19 with liver metastases and 7 with HCC. Yttrium-90 treatment activities were calculated by body surface area method. Tumor imaging response was assessed by Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 for liver metastases and modified RECIST for HCC. Clinical side effects and adverse events were graded per Common Terminology Criteria for Adverse Events version 4.0.Results
All planned cases were technically successful, and no cases were canceled for elevated LSF or vascular anatomic reasons. Pretreatment angiography modified the planned 90Y treatment activity in 1 case in which vascular anatomy required a lobar-dose split into 2 for segmental infusions. In 18% of cases, patients were briefly admitted after the procedure for observation or symptom management. Imaging evaluation of initial efficacy at 1 month demonstrated partial response in 25% and stable disease in 67% of patients with liver metastases and partial/complete response in 43% and stable disease in 14% of patients with HCC. Grade ≥ 3 adverse events occurred in 6% of cases, with no systemic therapy–limiting toxicities. The mean total procedure time was 4.2 hours.Conclusions
A same-day 90Y radioembolization protocol with resin microspheres is feasible in select patients, which can expedite cancer therapy. 相似文献83.
84.
85.
全国名中医天津中医药大学第一附属医院针灸科武连仲教授用多年的临床经验总结概括出针刺的理、法、方、穴、术,其创立的"通经止痛"针刺疗法在临床中疗效佳,武老在治疗坐骨神经痛时,取足太阳膀胱经和足少阳胆经具有走窜针感的经穴为主穴,其配伍精确,组方严密,手法独特,可供临床参考。本文将武老运用"痛经止痛"针刺法治疗坐骨神经痛的经验从"理、法、方、穴、术"方面做浅述。 相似文献
86.
目的 针对中医药大数据平台传统的加密方案效率不高的问题,提出一种高效的基于属性的内积加密的数据脱敏算法。方法 Hash(哈希)算法是应用广泛的高效的数据加密方法,但传统的哈希算法基于单一的控制策略,效率不高。本文提出一种基于属性的内积加密的数据脱敏算法,把批量的敏感数据分割为不同长度数据颗粒度,与特定密文的哈希进行内积处理。结果 在面对中医药大数据平台的海量数据加密的场景,与传统的哈希加密算法相比,本文提供的加密算法具有很好的性能。结论 为了保障个人隐私数据不被泄露,中医药大数据平台中的个人医疗数据需要加密脱敏后,才能进行分析处理或对外发布。本文提出的算法具备灵活的数据颗粒度、策略和高效的性能表现,适用于海量的中医药数据脱敏。 相似文献
87.
目的研究阴道锥体训练联合生物反馈盆底肌治疗尿失禁老年人的临床疗效及对盆底肌的影响。方法选取84例从2016年9月至2018年3月本院收治的尿失禁老年患者进行研究,以随机抽签法将其均分为联合组及对照组,每组42例。对照组予以常规盆底肌训练治疗,联合组则予以阴道锥体训练联合生物反馈盆底肌治疗。对比两组在临床疗效、治疗前后盆底肌力情况、治疗前后尿动力学参数指标水平以及生活质量变化情况等方面的差异。结果联合组与对照组在总有效率方面比较,前者高于后者(P<0.05)。治疗后联合组盆底肌力分级为Ⅳ级、Ⅴ级的人数占比相比对照组较高(P<0.05)。治疗后联合组与对照组在VLPP、PMUC水平方面比较,前者高于后者(P<0.05)。治疗后联合组与对照组I-QOL评分相比治疗前较高,且联合组相比对照组较高(P<0.05)。结论阴道锥体训练联合生物反馈盆底肌治疗老年尿失禁患者的疗效显著,有利于促进盆底肌力的恢复,且有效改善患者尿动力学参数,提高生活质量,具有较高的临床推广应用价值。 相似文献
88.
Shisong Zhang Juan Li Yurui Wu Yuanjun Hu Chunhong Duan Meiyun Wang Zhongtao Gai 《Medicine》2015,94(39)
The purpose of this meta-analysis is to compare the relative merits among laparoscopic-assisted operations and laparotomy operations for patients with Hirschsprung disease.PubMed, Web of Science, and Wanfang databases were searched for the related articles. We analyzed dichotomous variables by estimating odds ratios (ORs) with their 95% confidence intervals (CIs) and continuous variables using the weighted mean difference (WMD) with the 95% CI. The random-effects model (REM) was used to combine the results. The outcome measures included operating time (OT), estimated blood loss (EBL), length of hospital stay (LOHS), mean first bowel movement (MFBM), and number of complications.Sixteen articles were included in the meta-analysis. These studies involved a total of 774 patients, 396 of whom underwent laparoscopic-assisted operations and 378 of whom underwent laparotomy operations. The EBL (WMD = −1.48, 95% CI = −1.82, −1.13), LOHS (WMD = −0.67, 95% CI = −0.86, −0.49), MFBM (WMD = −0.83, 95% CI = −1.05, −0.61), and number of complications (OR = 0.60, 95% CI = 0.40, 0.89) were significantly lower in laparoscopic-assisted operations than in laparotomy operations. The OT (WMD = 0.12, 95% CI = −0.05, 0.28) showed no significant differences between laparoscopic-assisted operations and laparotomy operations.Compared with laparotomy operations, laparoscopic-assisted operations are generally safer and more reliable for patients with Hirschsprung disease. 相似文献
89.
Quantitative chemical exchange saturation transfer (qCEST) MRI – omega plot analysis of RF‐spillover‐corrected inverse CEST ratio asymmetry for simultaneous determination of labile proton ratio and exchange rate
下载免费PDF全文
![点击此处可从《NMR in biomedicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Renhua Wu Gang Xiao Iris Yuwen Zhou Chongzhao Ran Phillip Zhe Sun 《NMR in biomedicine》2015,28(3):376-383
Chemical exchange saturation transfer (CEST) MRI is sensitive to labile proton concentration and exchange rate, thus allowing measurement of dilute CEST agent and microenvironmental properties. However, CEST measurement depends not only on the CEST agent properties but also on the experimental conditions. Quantitative CEST (qCEST) analysis has been proposed to address the limitation of the commonly used simplistic CEST‐weighted calculation. Recent research has shown that the concomitant direct RF saturation (spillover) effect can be corrected using an inverse CEST ratio calculation. We postulated that a simplified qCEST analysis is feasible with omega plot analysis of the inverse CEST asymmetry calculation. Specifically, simulations showed that the numerically derived labile proton ratio and exchange rate were in good agreement with input values. In addition, the qCEST analysis was confirmed experimentally in a phantom with concurrent variation in CEST agent concentration and pH. Also, we demonstrated that the derived labile proton ratio increased linearly with creatine concentration (P < 0.01) while the pH‐dependent exchange rate followed a dominantly base‐catalyzed exchange relationship (P < 0.01). In summary, our study verified that a simplified qCEST analysis can simultaneously determine labile proton ratio and exchange rate in a relatively complex in vitro CEST system. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
90.
Bryan E.K. Guevara Suhail Saleem Wan‐Ting Chen Pa‐Fan Hsiao Yu‐Hung Wu 《Journal of cutaneous pathology》2019,46(5):347-352
Lucio phenomenon is an atypical reaction of leprosy, characterized by vasculitic lesions that can mimic antiphospholipid syndrome (APS) clinically. Distinguishing the two can be difficult as antiphospholipid autoantibodies may be present in patients with leprosy. We report on a 32‐year‐old female patient presenting with a sudden onset of fever, hemorrhagic bullae, and skin necrosis on her lower legs. She was treated for APS due to the presence of antiphospholipid antibodies but had an inadequate response. A skin biopsy revealed thrombotic vasculopathy and necrotizing vasculitis associated with aggregation of foam cells in the perivascular area and subcutis, with acid‐fast bacilli in the histiocytes and blood vessel walls. Direct immunofluorescence showed IgM, C3, and fibrinogen deposition in the superficial and deep dermal blood vessels. The pathology confirmed the diagnosis of Lucio phenomenon, and appropriate therapy was given. It is essential to evaluate the patient comprehensively, including clinical, serological, and pathological aspects, to obtain the correct diagnosis. 相似文献