双胞胎遗传性乳光牙本质1例及家系调查

目的分析双胞胎姐妹遗传性乳光牙本质的临床表现及探讨修复治疗。方法征询调查1例双胞胎姐妹遗传性乳光牙本质家系患病情况。结果追溯双胞胎姐妹遗传性乳光牙本质4代家系,共20人,男8人,女12人,其家系中共有7人罹患遗传性乳光牙本质。结论双胞胎姐妹同时罹患遗传性乳光牙本质者未见报道,对家族性遗传性疾病具有一定的临床研究价值。     

遗传性乳光牙本质系谱调查及修复治疗1例

遗传性乳光牙本质是一种牙本质发育异常的常染色体显性遗传病,发病率低。本文报道1例遗传性乳光牙本质患者的家系调查及修复治疗,并探讨该病的发病机制和治疗方法。     

Micro-CT对遗传性牙本质发育缺陷离体患牙的特征研究

目的 采用Micro-CT构建Ⅱ型牙本质发育不全(DGI-Ⅱ)和Ⅰ型牙本质发育不良(DD-Ⅰ)离体患牙的三维结构,研究该类患牙的内部结构及硬组织矿化密度的变化.方法 收集同龄DGI-Ⅱ、DD-Ⅰ患者及健康者的第三磨牙,运用Micro-CT对3份样本逐一扫描并通过Mimics 17.0重建三维结构;截取矢状面和横断面观察...     

牙本质发育不全1例

发生于牙本质的发育异常主要有两大类,一类为牙本质发育不全(dentinogenesis imperfecta DGI),另一类为牙本质发育异常症或者牙本质生成不全(dentin dysplasia DD).以牙冠变色磨耗及髓腔改变为主要特征[1].牙本质发育不全分为三型:即牙本质发育不全Ⅰ型(DGI-Ⅰ);牙本质发育不全Ⅱ型(DGI-Ⅱ)又称遗传性乳光牙本质;牙本质发育不全Ⅲ型(DGI-Ⅲ).笔者遇到一例遗传性乳光牙本质,现报道如下.     

遗传性乳光牙本质病的家系调查及修复方法

目的:了解遗传性乳光牙本质(又名牙本质发育不全Ⅱ型,DGI-Ⅱ)的遗传特征,探讨其治疗方法。方法:调查在上海发现的1例遗传性乳光牙本质患者的家系成员,进行系谱分析。对先证者作金瓷修复体治疗,并调查该家系受累者的修复情况。结果:该遗传性乳光牙本质家系中,患者连续5代出现,子代患病率接近50%。该家系子代义齿修复率90%,修复方式包括金瓷修复体和可摘局部义齿,以金瓷修复体为主,修复后美观和咀嚼功能良好。结论:遗传性乳光牙本质家系发病率高,金瓷修复体能达到预防牙体磨损和崩裂、恢复美观和咀嚼功能的效果。     

一例遗传性乳光牙本质的治疗及家系调查

目的：探讨遗传性乳光牙本质治疗修复的特殊性、可行性及操作中应注意的问题。方法：通过对1例遗传性乳光牙本质患者的家系调查,治疗修复及双颌的咬合重建,恢复患者的最适颌位,并随访观察疗效。结果：遗传性乳光牙本质家系中涉及4代9人患病。对先证者进行治疗,并经6年临床随诊观察,患者对修复体较满意。结论：遗传性乳光牙本质患者采用多种治疗修复方法可恢复牙齿美观及咀嚼功能。     

一例牙本质发育不良Ⅰ型患者的临床特点及其种植治疗

牙本质发育不良Ⅰ型（dentin dysplasia type Ⅰ,DD-Ⅰ）是一种伴有牙本质形成障碍、可遗传的罕见病。其特征是牙冠正常，但牙根发育异常，出现短、钝化和畸形的牙根；在患者年轻时即出现牙松动，可伴牙槽脓肿；影像学上表现为闭塞的牙髓腔。典型的DD-Ⅰ是常染色体显性遗传，家系中患者常很早即出现多颗牙丧失，有的30多岁即可表现为无牙颌。本文报告了一例DD-Ⅰ病例，通过总结其临床表现、影像学及组织学特点以及相关治疗，以期为DD-Ⅰ临床诊治提供指导。     

牙本质发育异常分类方法进展及相应临床管理策略

位于第4常染色体的牙本质涎磷蛋白(dentin sialophosphoprotein, DSPP)基因是迄今发现的遗传性牙本质发育异常的主要致病基因。根据de La Dure-Molla等提出的新分类, 将由DSPP基因突变引起的主要表现为牙本质发育异常的疾病统称为牙本质发育不全(dentinogenesis imperfecta, DI), 包括Shields分类法的牙本质发育不良Ⅱ型(dentin dysplasia type-Ⅱ, DD-Ⅱ)、牙本质发育不全Ⅱ型(dentinogenesis imperfecta type-Ⅱ, DGI-Ⅱ)和牙本质发育不全Ⅲ型(dentinogenesis imperfecta type-Ⅲ, DGI-Ⅲ)3种疾病。将Shields分类的牙本质发育不良Ⅰ型(dentin dysplasia type-Ⅰ, DD-Ⅰ)称为根部牙本质发育不良(radicular dentin displasia)。本文对遗传性牙本质发育异常的分类方法、临床特征、致病基因的研究进展进行阐述, 根据不同阶段的临床特征, 提出相应的临床管理和治疗策略。     

牙齿发育缺陷综合征临床、病理及遗传学分析——附1例报告

目的:收集及分析1例牙齿发育缺陷综合征患儿,探讨该疾病的实质病因.方法:采用临床、实验室检查和遗传学方法对患儿进行临床病理诊断及致病候选基因筛选,并通过基因测序方法探寻突变位点.结果:该患儿的临床及病理学表现比较复杂,既有遗传性牙本质发育不全和牙根发育缺如的牙齿症状,又有外胚叶发育不全的全身表现.初步筛选和分析致病候选基因EDA,基因突变型为1231T＞C,L330P.结论:该疾病是一种新表型的牙齿发育缺陷综合征,其EDA基因型是导致此患儿疾病部分表型的影响因素.     

遗传性牙釉质发育不全家系调查及治疗1例报告

报告1例遗传性牙釉质发育不全病例。患者女,18岁,全口牙表面粗糙,呈黄褐色,大部分釉质脱落。其家族中多人患此病。对患者的病变牙进行了初步治疗,并提出了下一步治疗方案。     

乳牙滞留伴多颗多生牙及恒牙阻生1例报告

<正>多生牙也称额外牙,是一种牙齿数目的发育异常,可发生在牙弓的任何部位,其中以上颌前牙区多见。国内报道的恒牙列多生牙发生率为1%～3%[1],国外为1.04%～2.00%[2]。其中85.4%的患者只有1～2颗多生牙,3颗以上者少见[3]。本病例4颗多生牙伴乳牙滞留、恒牙阻生,导致恒牙远离牙槽骨正常位置,牙槽骨缺损失去保留价值,在临床上比较少见,总结报道如下。     

乳牙釉、牙本质钙含量之分析研究

目的:分析探讨乳牙釉质、牙本质钙含量状况与龋病关系。方法:对37例5~7岁幼儿园乳恒牙替换所拔除的下颌乳中切牙,用电子探针X线显微分析仪检测各牙之近中侧、远中侧、唇侧和舌侧之釉质和牙本质不同深度之钙含量。受检测牙37颗(1|18颗,|119颗)。37例中dft=0者14名,为无龋组;dft>0者23名,为有龋组。有龋组中0相似文献   

Prosthodontic Management of a Child with Ectodermal Dysplasia: A Case Report

Ectodermal dysplasia is a rare congenital disease that affects several ectodermal structures. Children with ectodermal dysplasia may have various manifestation of the disease that differ in severity and may or may not involve teeth, skin, hair, nails, sweat glands and sebaceous glands. The most common form of the ectodermal dysplasia syndrome is hypohidrotic ectodermal dysplasia and is usually inherited as an X-linked recessive trait. Female carriers may have a variable degree of clinical manifestations. This case report discusses the management of a 5-year-old girl with ectodermal dysplasia. Clinical management consisted of fabricating upper and lower dentures to help in psychosocial development and to restore the vertical dimension, esthetics and functioning of the stomatognathic system.     

Prosthetic Rehabilitation of a Cleidocranial Dysplasia Patient with Vertical Maxillofacial Deficiency: A Clinical Report

Cleidocranial dysplasia (CCD) is a rare congenital disorder characterized by skeletal and dental anomalies. This clinical report describes the prosthodontic approach to treating a CCD patient who presented with decreased facial height and relative mandibular protrusion due to maxillary hypoplasia after orthodontic treatment. Functional and esthetic rehabilitation was achieved using telescopic detachable prostheses in the maxilla and osseointegrated implants and metal‐ceramic fixed dental prostheses in the mandible. These treatment approaches precluded the need for orthognathic surgical correction and presented a favorable prognosis during the 5‐year observation period.     

Full Mouth Rehabilitation of a Hypohidrotic Ectodermal Dysplasia Patient with Dental Implants: A Clinical Report

Prosthodontic treatment in patients with ectodermal dysplasia (ED) is difficult to manage because of the oral deficiencies typical in this disorder and because afflicted individuals are quite young when they are evaluated for treatment. This clinical report describes an 18-year-old patient with hypohidrotic ED treated with dental implants. Treatment included a maxillary implant overdenture and a mandibular hybrid prosthesis supported by osseointegrated implants. At the one-year follow-up, the patient presented significant improvements in oral function and psychosocial activities.     

Deciduous Tooth Pulp Autotransplantation for the Regenerative Endodontic Treatment of Permanent Teeth With Pulp Necrosis: A Case Series

IntroductionIn young individuals, deciduous tooth pulp might be used as a natural, biologic scaffold for the regenerative endodontic treatment (RET) of young permanent teeth with necrotic pulps and apical periodontitis. The present case series demonstrates the clinical and radiographic outcomes of a novel RET using deciduous pulp autotransplantation in traumatized, necrotic young permanent incisors.MethodsFive previously traumatized maxillary incisors of four 8- to 11.5-year-old patients were treated with a RET protocol that used 2.5% NaOCl irrigation and placement of calcium hydroxide dressing in the first visit. After 4 weeks, the intracanal medication was removed, and the whole pulp tissue harvested from the neighboring maxillary deciduous canine was transplanted into the disinfected root canal without induced apical bleeding. Following placement of a mineral trioxide aggregate coronal barrier, the access cavities were restored with acid-etch resin composite. The root canals of donor primary canines were filled with calcium hydroxide-iodoform paste and were restored as with the permanent incisors.ResultsThree patients were followed-up for 24 months, and 1 patient for 12 months. All teeth demonstrated radiographic evidence of complete periapical healing, slight increase in dentinal wall thickness, and continued apical closure in the absence of clinical symptoms. A positive response to cold test was obtained in 1 incisor at 12 months and 2 at 24 months.ConclusionsBased on 12- and 24-month clinical and radiographic findings, the present cases demonstrate a favorable outcome of a RET protocol using deciduous pulp autotransplantation in young permanent incisors with pulp necrosis.     

Prepubertal Periodontitis Affecting the Deciduous and Permanent Dentition in a Patient With Cyclic Neutropenia: A Case Report and Discussion

Neutropenia is a transient or chronic blood disorder characterized by a decrease in the number of circulating polymorphonuclear leukocytes (PMNs). Neutrophils are a major cellular defense against infection, and depletion of these cells is potentially fatal. Stomatitis and gingivitis frequently are seen in patients with neutropenia. Therefore, the diagnosis of severe oral pathoses of obscure origin must include a differential white blood cell count. The importance of the dentist's role is dramatically illustrated in the rare case reported here, since the oral condition was the reason for this patient's definitive blood work-up. The report illustrates the importance of the laboratory assessment in dental patients with unusual periodontal destruction or other inexplicable oral changes.     

Restoration of Atrophic Edentulous Maxilla of a Patient with Ectodermal Dysplasia Using Quadruple Zygomatic Implants: A Case Report

Rehabilitation of patients with ectodermal dysplasia often presents clinical challenge due to hypodontia, anodontia, and severe atrophy of edentulous ridges. Zygomatic implant therapy can be used as a method of achieving osseointegration without bone grafting in such situations. This clinical report describes the dental rehabilitation of atrophic maxilla of a 26-year old female patient with a fixed prosthesis, immediately loaded on four zygomatic implants.     

Clinical and Molecular Microbiological Evaluation of Regenerative Endodontic Procedures in Immature Permanent Teeth

IntroductionThis study evaluated the bacterial levels after regenerative endodontic procedures and their correlation with the treatment outcome using molecular microbiology methods.MethodsRoot canal samples of 15 necrotic immature teeth were analyzed by quantitative polymerase chain reaction. Bacteria were counted before treatment (S1), after irrigation with 6% sodium hypochlorite (S2), and after intracanal dressing (S3) using either triple antibiotic paste (n = 7) or calcium hydroxide with chlorhexidine (n = 8). The Wilcoxon test for related samples and the Mann-Whitney test were used for statistical analysis (P < .05). After a follow-up period of 12–48 months, clinical and radiographic findings were correlated with microbiological data using a linear regression model (P < .05).ResultsAll S1 and S2 samples were positive for bacteria, but the number of positive S3 samples decreased to 53.3% (P = .001). Overall, there was a significant reduction of bacterial levels after each treatment step (S1–S2, P = .001; S2–S3, P = .02). In the triple antibiotic paste and chlorhexidine groups, 57.1% and 50% of S3 samples were positive with median numbers of 6.97 × 10³ and 3.59 × 10⁴ bacterial cells, respectively. No significant differences were found between the groups. Periapical healing occurred in all cases despite the presence of low levels of residual bacteria. However, the latter had a negative impact on the thickness of dentinal walls (R² = 0.0043).ConclusionsAlthough the bacterial levels were drastically reduced after the regenerative endodontic procedures, the residual bacteria influenced the thickness of the dentinal walls.