595nm脉冲染料激光治疗鲜红斑痣回顾性分析

目的观察595nm脉冲染料激光治疗鲜红斑痣的临床疗效。方法应用595nm脉冲染料激光治疗647例鲜红斑痣患者,观察临床疗效及副作用。结果粉红型、鲜红/紫红型及增厚/结节型平均治疗次数分别为3.61次、4.87次及4.57次。随着治疗次数的增加,疗效逐渐提高。粉红型、鲜红/紫红型及增厚/结节型的总有效率分别为80.24%,75.86%及65.21%。经Chi-square检验,前两型疗效无统计学差异,但均优于后者。术后副作用少。结论595nm脉冲染料激光治疗鲜红斑痣疗效确切,安全性高。     

595 nm脉冲染料激光治疗鲜红斑痣1560例临床研究

目的 评价595 nm脉冲染料激光治疗不同年龄段鲜红斑痣患者的临床疗效和不良反应。方法 应用美国Candela公司生产的595 nm脉冲染料激光治疗鲜红斑痣1560例,根据患者年龄、皮损类型等采用不同参数进行激光照射治疗。结果 595 nm脉冲染料激光治疗鲜红斑痣总有效率为76.73%（1197/1560）,疗效与患者年龄、皮损类型等因素关系密切,不良反应发生率低,且耐受性好。结论 595 nm脉冲染料激光治疗鲜红斑痣安全有效。     

595nm脉冲染料激光治疗儿童鲜红斑痣69例疗效观察

目的:观察595 nm脉冲染料激光治疗儿童鲜红斑痣的临床疗效。方法:选取来我院就诊的儿童面颈部鲜红斑痣69例,其中粉红型52例、紫红型11例,增厚型6例,采用595 nm脉冲染料激光进行治疗。比较儿童不同类型鲜红斑痣的疗效。结果:鲜红斑痣中粉红型总有效率为100%,紫红型和增厚型的总有效率分别90.91%和83.33%。粉红型与紫红型间总有效率差异无统计学意义(2=1.95,P0.05);而粉红型与增厚型(2=64.46,P0.05)、紫红型与增厚型(2=57.32,P0.05)间总有效率差异有统计学意义。结论:595 nm脉冲染料激光治疗儿童皮肤鲜红斑痣疗效确切。粉红型及紫红型鲜红斑痣疗效较增厚型鲜红斑痣好。     

595nm脉冲染料激光治疗儿童鲜红斑痣69例疗效观察

目的:观察595 nm脉冲染料激光治疗儿童鲜红斑痣的临床疗效。方法:选取来我院就诊的儿童面颈部鲜红斑痣69例,其中粉红型52例、紫红型11例,增厚型6例,采用595 nm脉冲染料激光进行治疗。比较儿童不同类型鲜红斑痣的疗效。结果:鲜红斑痣中粉红型总有效率为100%,紫红型和增厚型的总有效率分别90.91%和83.33%。粉红型与紫红型间总有效率差异无统计学意义(2=1.95,P>0.05);而粉红型与增厚型(2=64.46,P<0.05)、紫红型与增厚型(2=57.32,P<0.05)间总有效率差异有统计学意义。结论:595 nm脉冲染料激光治疗儿童皮肤鲜红斑痣疗效确切。粉红型及紫红型鲜红斑痣疗效较增厚型鲜红斑痣好。     

鲜红斑痣部位发生化脓性肉芽肿1例

1 病历摘要 刘某某，男，10岁。因右颊部红斑10年，近1个月红斑边缘出现肿物、出血而就诊。患者于出生后面部右颊皮肤有一小片红斑，不规则椭圆形，     

595nm与585nm激光治疗鲜红斑痣的疗效比较

本中心１９９８年８月～２００１年８月,应用５９５nm和５８５nm波长激光治疗鲜红斑痣２６９例,其疗效差异有非常显著性。现将结果报告如下。１临床资料１．１一般资料２６９例鲜红斑痣患者均为本中心门诊病人。具有典型的临床表现。其中男７５例,女１９４例。平均年龄１８．３８岁（２个月～５０岁）。皮损面积１～５００cm２。皮损主要发生于面部,其次为颈部、上肢和躯干。淡红斑７９例,鲜红斑１７７例,紫红斑或伴结节１３例。有既往治疗史者１９例,其中同位素治疗１０例,冷冻６例,铜蒸气激光３例,均留有不同程度的瘢痕、色素减…     

脉冲染料激光治疗258例鲜红斑痣临床分析

258例鲜红斑痣患者应用不同能量级别的脉冲染料激光治疗,总有效率78．29％,痊愈率8．91％,副作用轻微,仅表现为短斩的色素沉着或色素脱失,无1例出现瘢痕。     

595 nm可调脉宽激光治疗鲜红斑痣190例

鲜红斑痣又称毛细血管扩张痣或葡萄酒样痣。是一种先天性毛细血管畸形,为真皮中上部毛细血管扩张,多发生于面、颈部,影响患者的身心健康。我们于2002年12月—2004年9月应用595nm可调脉宽染料激光(Vbeam血管治疗仪,美国凯黛乐公司生产)治疗面颈部鲜红斑痣190例,取得良好效果。现     

泵脉冲染料激光治疗194例鲜红斑痣疗效分析

鲜红斑痣为一种先天的皮肤毛细血管发育异常,在皮肤的浅层形成毛细血管丛,其发病率为０．３％,大部分发生面部和颈部,约８５％的患者发生在单侧,严重影响了患者的面容,疾病在出生时为淡红色斑,逐渐发展为暗红色斑或紫红色斑,部分可出现结节,在成人时皮损面积也增大［１］。泵脉冲染料激光是第一个根据选择性光动力学原理制造的激光机,它可选择性的破坏毛细血管而不损坏周围的真皮和表皮。研究表明泵脉冲染料激光治疗鲜红斑痣是有效和安全的［２］。 北京协和医院于１９９８年开始使用美国塞诺秀公司生产的 Ｐｈｏｔｌｏ Ｇｅｎｉ…     

595 nm脉冲染料激光治疗546例鲜红斑痣疗效评价

目的评价595 nm脉冲染料激光治疗鲜红斑痣临床疗效和不良反应。方法应用美国Candela公司生产的595 nm脉冲染料激光治疗鲜红斑痣546例,根据患者年龄、皮损类型等采用不同参数进行激光照射治疗。结果 595 nm脉冲染料激光治疗鲜红斑痣总有效率为70.33%(384/546),疗效与患者年龄、皮损类型等因素关系密切,不良反应发生率低,且耐受性好。结论 595 nm脉冲染料激光治疗鲜红斑痣安全有效。     

Treatment of port-wine stains with the 595-nm pulsed dye laser: a pilot study in Chinese patients

The 595-nm pulsed dye laser (PDL) is one of the newest developments in the treatment for port-wine stains (PWS). The aim of this study was to investigate the effectiveness of the treatment of PWS in Chinese patients using the 595-nm PDL. In total, 184 patients with PWS over the face, neck and trunk or limbs were enrolled in the study. All the patients were treated with the 595-nm PDL 3-6 times, with a 4-week interval between each treatment. Treatment parameters varied for each patient according to the colour and location of the PWS. The efficacy of treatments and any side-effects were evaluated. Results were graded as percentage resolution (0-25%, 25-50%, 50-75% and 75-100%). Of the 184 patients who completed the study, 115 (62.5%) achieved excellent improvement, 38 (20.7%) achieved good results, and 31 (16.8%) had an unsatisfactory outcome (moderate and poor response). We found > 75% improvement for 76% of facial PWS (95/125), 43% of neck PWS and 20.8% of trunk or limb PWS. Pain and topical erythema were commonly reported immediately after the laser treatments. Prominent hyperpigmentation occurred in only 11 cases (6.0%) with poor improvement, and resolved within 6 months. The 595-nm PDL appears to be safe, effective and well tolerated in the treatment of PWS in Chinese patients.     

Topical application of 5-aminolevulinic acid followed by 595-nm pulsed dye laser irradiation for the treatment of recalcitrant port-wine stains: A primary study

Abstract

Objective: To evaluate the effectiveness and safety of topical application of 5-aminolevulinic acid (ALA) followed by pulsed dye laser (PDL) irradiation for the treatment of recalcitrant port-wine stain (PWS). Methods: Thirty-five patients (19 females and 16 males) with recalcitrant PWS were treated with topical application of 20% ALA and then irradiated with a 595-nm PDL (energy density of 6.5–9.0 J/cm² and pulse duration of 6 or 10 ms) at 6–8 weeks intervals. Clinical improvement of lesions was evaluated by comparing photographs of lesions at baseline and 2 months after the last treatment. Results: Topical ALA spreading followed by irradiation with a 595-nm PDL improved PWS in 21 out of 35 patients who were previously recalcitrant to PDL treatment alone. Side effects were limited to transient erythema, vesicle formation, edema and mild purpura with no obvious subsequent scarring or undesirable pigment changes. Conclusion: The topical application of ALA followed by irradiation with a 595-nm PDL is an effective and safe treatment for PWS recalcitrant to PDL therapy alone.     

Genital angiokeratomas of Fordyce 595-nm variable-pulse pulsed dye laser treatment

Background: Angiokeratoma of Fordyce (AF) represents dark red or blue-black papules with a scaly surface located on scrotum, labia majora, and penis. Though usually asymptomatic, bleeding after mechanical trauma and sexual intercourse may occur. AF should be differentiated from malignant melanoma, angiosarcoma, and other pigmented lesions. The treatment, usually asked from patients as the result of anxiety and social embarrassment, should be performed in a non-aggressive manner. Objectives: To determine the safety and effectiveness of 595-nm variable-pulse pulsed dye laser (VPPDL) with a Dynamic Cooling Device (DCD) in the treatment of AF. Methods: Twenty-four patients (22 men and two women) aged 40.88 ± 12.48 years with AF were included in the retrospective study. Lesions located on scrotum, labia majora, and penis were treated with 595-nm VPPDL in the intervals of one to three months. Variable spot, fluence, and pulse-width parameters were used with and/or without DCD skin cooling. Results: AF were successfully removed in all patients in one to seven (mean ± SD = 3.38 ± 2.16) treatment sessions with no permanent side effects or complications such as dyspigmentations or scarring. Recidives were observed in four patients after 0.5–1 year intervals. Conclusions: 595-nm VPPDL with DCD represents an efficient and safe method for the removal of multiple lesions of AF in genital localization.     

A comparative study of a 595-nm with a 585-nm pulsed dye laser in refractory port wine stains

BACKGROUND: The pulsed dye laser (PDL) is the treatment of choice for port wine stains (PWS); however, some patients' PWS become refractory to further treatments. Technological advances have enabled new machines with the advent of surface cooling devices to deliver longer wavelengths and higher fluence more safely. These advances have the potential to achieve improved response rates in refractory PWS. There are few studies comparing the efficacy of standard PDL treatments for refractory PWS with the wider choice of treatment variables available from newer PDL machines. OBJECTIVES: To determine if there is any advantage of using a longer wavelength (595 nm) and pulse widths (1.5 ms, 6 ms and 20 ms) over conventional PDL settings (wavelength 585 nm, pulse width 1.5 ms) in refractory PWS. METHODS: Eighteen consecutive consenting patients with Fitzpatrick skin types 1-4 with a mean age 35 years (range 17-59 years) with refractory PWS were treated routinely with three separate test areas using 595-nm PDL (using three different pulse width settings of 1.5 ms, 6 ms and 20 ms), compared with test areas treated with 585-nm PDL (pulse width 1.5 ms). All test areas were treated with an identical fluence (15 J cm(-2)), spot size (7 mm) and cooling setting (dynamic cooling 60 ms, delay 60 ms). RESULTS: We found a statistically significant advantage of 595-nm PDL (pulse width 1.5 ms) over 595-nm PDL (pulse width 6 ms) (P < 0.05) in the treatment of refractory PWS; however, we found no significant advantage using longer pulse widths of 20 ms compared with 1.5 ms with the 595-nm PDL. There was no statistically significant advantage in using a 595-nm PDL over a 585-nm PDL using identical pulse widths of 1.5 ms, spot size, fluence and cryogen cooling settings; however, the number of directly comparable test areas was smaller. Some individual patients in our study obtained a better response with certain 595-nm PDL settings (pulse width 1.5 ms and 6 ms) compared with 585-nm PDL (pulse width 1.5 ms). CONCLUSIONS: Our experience of high fluence PDL in the treatment of refractory PWS suggests patients treated with 585 nm (pulse width 1.5 ms) improve to a similar degree as patients treated with 595-nm PDL (pulse width 1.5 ms). However, the use of the 595-nm PDL with longer pulse widths yields no extra advantage. For those patients who have failed to improve with high-fluence 585-nm PDL (pulse width 1.5 ms), test areas using 595-nm PDL (pulse width 1.5 ms and 6 ms) should be undertaken to ascertain if individual patients may benefit from the longer pulse width 595-nm PDL.     

Recurrence of port-wine stains after treatment with the flashlamp-pumped pulsed dye laser

OBJECTIVES: To assess the importance of the patient's age at the start of treatment of a port-wine stain (PWS) with the flashlamp-pumped pulsed dye laser (FPDL). BACKGROUND: FDPL treatment is safe and effective for PWSs, with a low risk of scarring and pigmentary changes. The degree of clearing of the lesion is, however, unpredictable, and the ideal time to start treatment has not yet been agreed. Patients/methods By means of a questionnaire, we investigated the frequency of recurrence in PWS in 147 patients after completion of treatment with the FPDL. RESULTS: In 24 patients (16.3%), partial redarkening of their PWS was observed. The patients who had a recurrence were not different from the group who did not regarding the colour of the PWS, the response to previous treatment or the frequency of side-effects. Children under 10 years of age did not show any PWS recurrence, at least in our group of patients. CONCLUSIONS: The age at the beginning of treatment may have an influence on the recurrence rate.     

The treatment of port-wine stains with the pulsed dye laser at 600 nm

The standard wavelength in the treatment of port-wine stains (PWS) with the pulsed dye laser is 585 nm. In many cases, the response to therapy is not adequate despite many treatments, depending partly on vessels out of reach of the laser. Longer wavelengths penetrate deeper into the dermis, but are absorbed less by oxyhaemoglobin, and require higher fluences. In this study, 22 patients with PWS were treated with the flashlamp-pumped pulsed dye laser using two different wavelengths, 585 and 600 nm. Four adjacent sites with PWS were treated on one occasion with 585 nm, 600 nm and equal fluence, and with 1.5 and 2 times the 585 nm fluence. The test areas were examined blindly, by four evaluators, an average of 12.5 weeks later. There was significantly less lightening with 600 nm than with 585 nm (P0.001) when equal fluences were used. When 1.5 and 2 times the 585 nm fluence were applied, with 600nm the lightening was equal to that after 585 nm. However, in individual cases (11 of 22) 600 nm showed a superior lightening of at least 20% compared to 585 nm. There was slight hyperpigmentation and hypopigmentation, but no atrophy or scarring. In conclusion, 585 nm remains the wavelength of choice in treatment of PWS with the pulsed dye laser. However, in cases that do not respond satisfactorily with 585 nm, it may be worth trying 600 nm with a fluence that is at least 1.5–2 times the 585 nm fluence.     

Combined treatment with 595-nm pulsed dye laser and 1550-nm erbium-glass fractional laser for traumatic scars

Facial scars can be caused by a traumatic event or indeed surgical procedures. Several treatment modalities have been suggested including surgical or resurfacing techniques, autologous fat transfer, and injection of fillers. However, these approaches have varying degrees of success and associated side effects. We report two Korean patients with traumatic scars. Both patients received combined consecutive treatment with 595-nm pulsed dye laser (PDL) and 1550-nm erbium-glass fractional laser. Both patients showed remarkable clinical improvements after a course of sessions. Therefore, simultaneous combined treatment with PDL and fractional laser may be considered a reasonable therapeutic option for traumatic facial scars.