共查询到20条相似文献,搜索用时 78 毫秒
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报告1例成人表皮痣综合征。患者男,28岁,因皮疹、智力低下、多动28年,间断抽搐27年就诊。皮肤科检查:额部、眼周、颈部可见弥漫性密集的淡褐至褐黑色乳头瘤样角化性丘疹,触之坚硬,似高起鱼鳞病、先天性良性黑棘皮病样。躯干、双上肢、四肢皮损角质增厚,较额部、眼周、颈部薄,可见弧形带状或旋涡状排列,不规则斑片状或斑点状色素脱失斑,与增生性皮损及正常皮肤相互交错。颈部皮损组织病理检查示纤维上皮性息肉改变,胸部皮损组织病理检查示表皮痣样改变。脑电图:脑电图异常伴高中波幅尖波及4~7 Hz的θ节律短阵出现。诊断为表皮痣综合征。 相似文献
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患者男,21岁。因腰痛、头痛伴双下肢无力6d于2002年5月20日入院。患者入院前6d,无明显诱因突然出现腰痛,半小时后出现头痛,以后枕部为重,呈持续性刀割样剧痛,伴呕吐,同时觉双下肢麻木无力,并由肢体远端迅速向胸腰部扩展,1h后胸腰部以下痛觉消失,双下肢完全不能活动,伴大小便失禁,但无抽搐,无发热等。在当地医院急诊,CT检查:双侧外侧裂及环池高密度影,脊髓内混杂密度影。给予甘露醇、6-氨基己酸等药治疗,症状无明显好转,且出现视物模糊,故转我院进一步诊治。既往史:患者发育正常,智力低下。出生后右侧躯干皮肤即有片状突起,咖啡色,随年龄增… 相似文献
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临床资料 患者男,21岁,因左肩部褐色斑5年,丘疹2年就诊。5年前患者左肩部无明显诱因出现浅褐色斑,无自觉症状。皮损逐渐扩大,颜色加深,曾到本院就诊,诊断为Becker痣,因不影响正常工作,生活,未予治疗。 相似文献
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患者女,17岁,右侧头面颈部泛发性褐色疣状增殖性皮损17年.右眼下睑泪囊区触及一质硬囊性肿物,右下泪小点缺如.眼眶核磁平扫:右眼泪囊区可见一类圆形肿物,压及筛窦及眼外肌.头面部皮损组织病理示:表皮角化过度,棘层增生肥厚,表皮乳头瘤样增生,真皮内可见大量成熟及不成熟的皮脂腺结构,部分见异位的大汗腺,诊断为皮脂腺痣.口腔右侧黏膜,包括右侧上腭及右半舌部见疣状赘生物;口腔全景片示右侧上下颌骨及牙槽骨发育欠佳.此外,双上肢可见大面积咖啡色斑片及褐色斑点.患者智力中等,既往有惊厥史.诊断:Schimmelpenning综合征.经皮肤外科手术后去除部分皮损. 相似文献
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患儿,女,4岁。患儿出生即出现全身干燥、红斑、鳞屑,伴渗液。头发、眉毛稀疏,口周皮沟加深,呈放射状,双手、双足可见片状、环状或多环状的红色斑片,其周边有小片灰白色“双边”鳞屑。光镜下见头发呈竹节状改变。血常规中嗜酸粒细胞计数增高,血清IgE增高。诊断:Netherton综合征。给予保湿剂外用。 相似文献
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Papillon-Lefevre syndrome: a case report 总被引:2,自引:0,他引:2
We report the first diagnosed case of Papillon-Lefevre syndrome in Thailand. The patient is the youngest child of consanguinous parents, and she has had symmetrical hyperkeratotic plaques on both plantar surfaces since birth with a history of chronic gingivitis, periodontitis, and premature loss of primary dentition. The histologic study revealed compact hyperkeratosis with epidermal acanthosis. Radiologic studies of the skull were normal. The radiographic panoramic view of the oral cavity revealed generalized severe vertical and horizontal alveolar bone loss. The immunologic analysis of polymorphonuclear leukocyte phagocytic function by nitrobluetetrazolium test (NBT test) showed decreasing response to latex stimulation. Serum parathyroid hormone, calcium, phosphate, and alkaline phosphatase levels were within normal limits. The skin lesions were temporary relieved with topical keratolytic agents. The oral lesions were improved by the extraction of hopeless teeth and conventional periodontal treatments. 相似文献
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Karaman A 《Dermatology online journal》2008,14(1):9
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous autosomal recessive disorder characterized by progressive retinal dystrophy, polydactyly, obesity, hypogonadism, mental retardation, and renal dysfunction. Other manifestations include diabetes mellitus, heart disease, hepatic fibrosis, neurological features, and multiple pigmented nevi. To date, twelve BBS genes have been cloned (BBS1-BBS12). Herein we discussed a patient with BBS who had multiple pigmented nevi. 相似文献