普萘洛尔对焦虑症的辅助治疗作用

目的：观察帕罗西汀联合普萘洛尔治疗焦虑症的临床疗效和不良反应。方法：205例广泛性焦虑患者随机分为研究组105例（帕罗西汀联合普萘洛尔治疗）,对照组100例（单用帕罗西汀治疗）,疗程6周。采用汉密尔顿焦虑量表（HAMA）、临床疗效总评量表（CGI）评定临床疗效;采用治疗中出现的症状量表（TESS）评定安全性。结果：研究组和对照组治疗总有效率分别为87.8%和75.5%,两组比较差异有统计学意义（P〈0.05）。研究组治疗2、4、6周时的HAMA减分率均高于对照组（P均〈0.01）。研究组头痛、心动过速、震颤等不良反应均较对照组少而轻。结论：帕罗西汀联合普萘洛尔治疗广泛性焦虑症具有良好的疗效和安全性,且优于单用帕罗西汀。

Adjunctive therapeutic effects of propranolol on anxiety disorders

Objective：To observe the clinical curative effect and adverse effect of paroxetine and propranolol in the treatment of anxiety disorders.Method：205 patients with generalized anxiety disorder were randomly divided into study group（n=105）and control group（n=100）.The study group was treated by paroxetine plus propranolol and control group by paroxetine for six weeks.Hamilton anxiety rating scale（HAMA）and clinical global impression（CGI）were used to evaluate clinical curative effect and treatment emergent symptoms scale（TESS）was used to assess the safety.Results：The total effective rate（87.8%）of the study group was significantly higher than that（75.5%）in the control group（P〈0.05）.The reduced rate of HAMA in study group was significantly higher than that in control group at weeks 2、4 and 6（P〈0.01）.The study group showed less and lighter adverse effects such as headache,tachycardia,tremor and so on than the control group.Conclusion：Paroxetine combined with propranolol has good efficacy and safety in treating general anxiety disorder and is better than paroxetine only.