MEBO与SD - Ag乳膏治疗放射性烧伤临床对比研究

目的 多年来人们一直主张采用磺胺嘧啶银( SD - Ag)乳膏或抗菌药物乳剂治疗放射性烧伤,但该方法疗程偏长,有些患者因久治不愈形成慢性溃疡,本研究旨在比较湿润烧伤膏(MEBO)与磺胺嘧啶银(SD- Ag)乳膏治疗水疱型放射性烧伤的临床疗效,寻找有效的治疗方法.方法 在2006年6月至2010年6月期间,采用随机分组表分组法,对水疱型放射性皮肤烧伤创面分别采用MEBO和SD - Ag乳膏治疗,前者为MEBO组,共计36例(处),后者为SD - Ag组,共计30例(处)；主要观察指标为各组创面自行愈合时间和接受植皮手术的创面个数,以及创面所发生的特殊变化.结果 MEBO组(36处)中有34处自行愈合,占总创面个数的94.4％,自愈创面的平均愈合时间为33.4 d±6.5d,另2例经过清创、移植自体皮肤封闭创面,植皮创面个数占本组创面个数的5.6％; SD-Ag组(30处)中有22处自行愈合,自愈创面的平均愈合时间为41.2d±9.9d,另8例(处)经过清创、移植自体皮肤封闭创面,植皮创面个数占本组创面个数的25.7％.结论 MEBO治疗水疱型放射性烧伤的临床疗效优于SD - Ag乳膏,可明显缩短创面愈合时间,降低手术几率.

Clinical Comparative Study of MEBO Wound Ointment with SD -Ag Cream in Treatment of Radioactive Burn Injuries

Objective SD -Ag ointment or antibiotic emulsion has always been applied as the therapy for radioactive burn injuries over the past years. Due to the delayed course of treatment, some patients are likely to develop chronic ulcers. This study is aimed to compare the therapeutic effects of MEBO Wound Ointment and SD - Ag in the treatment of blistered radioactive burn injuries in order to find an effective method. Methods From June 2006 to June 2010, 66 cases of blistered radioactive burn injuries were randomized into MEBO group （36 wounds） and SD -AG group （30 wounds ）, with MEBO Wound Ointment and SD - Ag applied in the two group respectively. The observation indicators included time of self - healing, numbers of wounds receiving skin - grafting surgery and the specific changes of wounds. Results In MEBO group （36 wounds） , 34 wounds were self - healed, counting up to 94.4% of total with the average duration of healing being 33.4 ±6. 5 days, and the other two wounds were cured by means of debridement and auto - grafting, counting up to 5.6% ; in SD - Ag group, 22 wounds were self - healed with the average duration of 41.2 ± 9. 9 days, and the other 8 cases （wounds） were cured by means of debridement and auto -grafting, counting up to 25.7%. ConclusionThe therapeutic effect of MEBO Wound Ointment was superior to that of SD - Ag cream in treating blistered radioactive burn injuries with no table acceleration of wound healing and decreased rate of operation.