| 灵芝多糖/硒化卡拉胶口服液对免疫抑制小鼠免疫功能的影响 |
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| 引用本文： | 张连龙,戴敏,毛兆祥,吴欣,张纯东,周店云.灵芝多糖/硒化卡拉胶口服液对免疫抑制小鼠免疫功能的影响[J].中国临床药理学与治疗学,2008,13(12). |
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| 作者姓名： | 张连龙 戴敏 毛兆祥 吴欣 张纯东 周店云 |
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| 作者单位： | 1. 无锡健特药业有限公司,无锡,214091,江苏
2. 安徽中医学院药学院,安徽省中药研究与开发重点实验室,合肥,230038,安徽 |
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| 摘 要： | 目的:研究灵芝多糖/硒化卡拉胶口服液对环磷酰胺诱导免疫抑制小鼠的非特异性免疫功能、体液免疫功能、细胞免疫功能的影响。方法:小鼠腹腔注射80mg/kg环磷酰胺诱导免疫抑制小鼠模型,灵芝多糖/硒化卡拉胶口服液连续供应30d,每天1次。测定小鼠单核巨噬细胞吞噬功能、腹腔巨噬细胞吞噬鸡红细胞功能、外周血白细胞数目、NK细胞活性、白介素-1(IL-1)活性、白介素-2(IL-2)活性、TNF-α活性、半数血清溶血素、抗体生成细胞、T、B淋巴细胞增殖能力、迟发型变态反应。结果:灵芝多糖/硒化卡拉胶口服液各剂量组(低剂量组:灵芝多糖2.5mg/kg+硒5μg/kg;中剂量组:灵芝多糖5mg/kg+硒10μg/kg;高剂量组:灵芝多糖15mg/kg+硒30μg/kg)均可提高外周血白细胞数目、提高半数溶血素值,低剂量组增强IL-1活性,中剂量组增强IL-2活性,高剂量组和中剂量组增强T、B淋巴细胞的增殖能力、NK细胞活性、TNF-α活性,高剂量组增强腹腔巨噬细胞吞噬功能、碳粒廓清值、提高抗体生成细胞、增强迟发型变态反应。结论:灵芝多糖/硒化卡拉胶口服液对免疫抑制小鼠的免疫功能具有改善作用。
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| 关 键 词： | 灵芝多糖/硒化卡拉胶口服液 非特异性免疫 体液免疫 细胞免疫 |
Effects of ganoderma liciudm ploysaccharide/seleno-k-carageenan syrup on immune function of immunosuppression mice |
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| ZHANG Lian-long,DAI Min,MAO Zhao-xiang,WU Xin,ZHANG Chun-dong,ZHOU Dian-yun.Effects of ganoderma liciudm ploysaccharide/seleno-k-carageenan syrup on immune function of immunosuppression mice[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2008,13(12). |
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| Authors: | ZHANG Lian-long DAI Min MAO Zhao-xiang WU Xin ZHANG Chun-dong ZHOU Dian-yun |
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| Institution: | 1 Wuxi Giant Pharmaceutical CO.; Ltd.; Wuxi 214091; Jiangsu; China; 2 College of Pharmacy; Anhui College of Traditional Chinese Medical; Anhui Key Laboratory of Modernized Chinese Material Medical; Hefei 230038; Anhui; |
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| Abstract: | AIM:To investigate the effects of ganoderma liciudm ploysaccharide(GLP)/seleno-κ-carageenan syrups on nonspecific immunity,humoral immunity,cell immunity function of immune suppressed mice induced by cyclophosphamide.METHODS:Immunity hypofunction mouse models were established by intraperitoneal injection of cyclophosphamide(80 mg/kg,o.d.)for 3 days,and ganoderma liciudm ploysaccharide/seleno-κ-carageenan syrups were administrated by gastric gavage for 30 days,once a day.The mononuclear phagocyte englobement... |
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| Keywords: | ganoderma liciudm ploysaccharide/seleno-κ-carageenan syrups nonspecific immunity humoral immunity cell immunity |
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