| 青蒿琥酯对盲肠结扎穿孔术脓毒症小鼠的保护作用 |
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| 引用本文： | 王宁,刘鑫,周红,曹红卫,李斌,鲁永玲,郑江.青蒿琥酯对盲肠结扎穿孔术脓毒症小鼠的保护作用[J].中国临床药理学与治疗学,2008,13(10). |
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| 作者姓名： | 王宁 刘鑫 周红 曹红卫 李斌 鲁永玲 郑江 |
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| 作者单位： | 1. 第三军医大学西南医院综合实验研究中心
2. 第三军医大学药学院药理学教研室,重庆,400038 |
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| 基金项目： | 国家重点基础研究发展规划(973计划) |
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| 摘 要： | 目的:探讨青蒿琥酯(AS)对盲肠结扎穿孔术(CLP)脓毒症小鼠的保护作用及其可能机制。方法:采用CLP制作小鼠脓毒症模型,术后0、4、24、48h重复肌肉注射AS,观察7d内CLP小鼠的死亡率;检测术后4、8h血浆脂多糖(LPS)、TNF-α、IL-6水平;术后8h小鼠肺脏组织形态的变化。结果:AS明显降低CLP小鼠的死亡率(P<0.05)及血浆LPS、TNF-α和IL-6水平(P<0.05或P<0.01),减轻肺组织的损伤。结论:AS对CLP小鼠具有显著的保护作用,该作用可能与其降低血浆LPS水平、减少促炎细胞因子TNF-α、IL-6的释放和减轻组织脏器的损伤有关。
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| 关 键 词： | 青蒿琥酯 脓毒症 盲肠结扎穿孔术 |
Protective effects of artesunate on mouse sepsis induced by cecal ligation and puncture |
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| WANG Li,LIU Xing,ZHOU Hong,CAO Hong-wei,LI Bing,LU Yong-ling,ZHENG Jiang.Protective effects of artesunate on mouse sepsis induced by cecal ligation and puncture[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2008,13(10). |
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| Authors: | WANG Li LIU Xing ZHOU Hong CAO Hong-wei LI Bing LU Yong-ling ZHENG Jiang |
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| Institution: | 1Medical Reseach Center; Southwest Hospital; Third Military Medical University; Department of Pharmacology; College of Pharmacy; 2Third Military Medical University; Chongqing 400038; China; |
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| Abstract: | AIM:To investigate the protective effects and related mechanisms of artesunate on mouse model of sepsis induced by cecal ligation and puncture(CLP).METHODS:The septic mouse models were established by CLP.Artesunate was administrated intramuscularly at 0,4,24 and 48 h after CLP.Mortality of CLP mice was observed in the next 7 days.Blood samples were collected at 4,8 h after CLP and the levels of LPS,TNF-α and IL-6 were detected by kinetic turbidimetric limulus test or ELISA,respectively.The morphological cha... |
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| Keywords: | artesunate sepsis cecal ligation and puncture |
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