| 中药活性成分大黄素用于治疗新型冠状病毒肺炎的可能性 |
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| 引用本文： | 杨磊,刘佳琦,边原,陈岷,帅小翠,童荣生,唐俊晖,蔡璐璐.中药活性成分大黄素用于治疗新型冠状病毒肺炎的可能性[J].今日药学,2020(4):229-234. |
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| 作者姓名： | 杨磊 刘佳琦 边原 陈岷 帅小翠 童荣生 唐俊晖 蔡璐璐 |
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| 作者单位： | 电子科技大学医学院;四川省医学科学院·四川省人民医院药学部;成都医学院 |
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| 基金项目： | 四川省中医药管理局研究基金(2018QN004);2020年第一批应对新型冠状病毒科技攻关应急项目(2020YFS0006);四川省科学技术厅重点研究发展计划(2019YFS0514)。 |
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| 摘 要： | 2019新型冠状病毒感染已严重威胁到人们的健康和生活,但目前尚无特效治疗药物对其进行有效的防控。大黄素作为蓼科植物大黄及虎杖的主要活性成分,具有广谱的抗病毒活性,对包括SARS冠状病毒(SARS-CoV)、流感病毒、HIV病毒、HBV病毒等的感染和复制具有抑制作用。因此,本文就抗SARS-CoV的中成药及中药复方、大黄素及复方制剂抗病毒的机制、含大黄及虎杖的复方制剂抗病毒的临床研究和大黄素用于治疗新型冠状病毒肺炎(COVID-19)的可能性进行综述,旨在探讨其治疗2019新型冠状病毒的临床可能性。
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| 关 键 词： | 新型冠状病毒炎 大黄素 药理作用 抗病毒 |
The Possibility of Using Emodin from Chinese Herbal Medicine as Treatment for COVID-19 |
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| YANG Lei,LIU Jiaqi,BIAN Yuan,CHEN Min,SHUAI Xiaocui,TONG Rongsheng,TANG Junhui,CAI Lulu.The Possibility of Using Emodin from Chinese Herbal Medicine as Treatment for COVID-19[J].Pharmacy Today,2020(4):229-234. |
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| Authors: | YANG Lei LIU Jiaqi BIAN Yuan CHEN Min SHUAI Xiaocui TONG Rongsheng TANG Junhui CAI Lulu |
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| Institution: | (School of Medicine,University of Electronic Science and Technology of China,Chengdu,Sichuan 610054,China;Department of Pharmacy,Personalized Drug Therapy Key Laboratory of Sichuan Province,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,Chengdu,Sichuan 610072,China;Chengdu Medical College,Chengdu,Sichuan 610500,China) |
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| Abstract: | Novel coronavirus has seriously threatened peoples health and lives,however,there is no effective available for in clinical treatment. As the main active ingredient of Rhei Radix et Rhizoma and Polygonum Cuspidatum Sieb.et Zucc,emodin has various pharmacological effects and can inhibit the replication and infection of many viruses,such as SARS-CoV,HIV,HBV and influenza virus.traditional Chinese medicine products containing emodin have been widely used in clinical treatments. We reviewed the recent studies on the antiviral effects of emodin,and discussed the clinical possibility of emodin for treating the COVID-19. |
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| Keywords: | COVID-19 emodin pharmacological effect antiviral |
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