| 中国南海Sinularia等珊瑚次级代谢产物的结构多样性 |
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| 引用本文： | 林文翰.中国南海Sinularia等珊瑚次级代谢产物的结构多样性[J].国外医学(药学分册),2013(6):670-677. |
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| 作者姓名： | 林文翰 |
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| 作者单位： | 北京大学天然药物及仿生药物国家重点实验室,北京100191 |
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| 摘 要： | 本文描述了作者从中国南海8种珊瑚中获得的次级代谢产物的结构多样性与新颖性。在获得的155种化合物中，130种为新颖结构化合物。部分化合物具有抗附着和抗肿瘤作用。研究表明海洋底栖生物存在大量的新颖结构，为进一步的药理学评价提供了丰富的模式化合物。
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| 关 键 词： | 软珊瑚 柳珊瑚 西松烷型 双西松烷型 抗附着 抗肿瘤 |
Structural diversity of the secondary metabolites derived from marine corals in the south China sea |
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| LIN Wen-han.Structural diversity of the secondary metabolites derived from marine corals in the south China sea[J].Foreign Medical Sciences(Section of Pharmarcy),2013(6):670-677. |
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| Authors: | LIN Wen-han |
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| Institution: | LIN Wen-han (State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China) |
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| Abstract: | This review reported the structural diversity and novelty of the secondary metabolites derived from eight marine cor- als in the south China sea. The structural patterns from eight coral species were summarized, in which 130 new compounds of a total of 155 derivatives were uncovered. Some of the secondary metabolites showed potent anti-fouling and anti-cancer activities. These findings indicated that marine organisms can provide structurally unique compounds for further pharmacological evaluation. |
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| Keywords: | soft coral gorgonian cembranoid biscembranoid antifouling anti-neoplastics |
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