| 高效液相色潽法检测复方二氧丙嗪茶碱片中茶碱含量 |
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| 引用本文： | 孙洪刚,王颖,李东伟,陈笑强,张椿影,崔雪丹,贾首时.高效液相色潽法检测复方二氧丙嗪茶碱片中茶碱含量[J].中国药师,2012,15(6):824-825. |
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| 作者姓名： | 孙洪刚 王颖 李东伟 陈笑强 张椿影 崔雪丹 贾首时 |
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| 作者单位： | 1. 齐齐哈尔市第一医院,黑龙江齐齐哈尔,161005
2. 齐齐哈尔市药品检验所 |
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| 摘 要： | 目的:建立高效液相色谱法检测复方二氧丙嗪茶碱片中茶碱含量.方法:色谱柱为Kromasil-C18(250 mm×4.6 mm,5 μm);流动相为水-甲醇(65:35);流速为1.0 ml·min-1;检测波长:275 nm.结果:茶碱在0.107～5.335 μg·ml-1范围内,与峰面积值呈良好的线性关系,r=0.999 7;平均加样回收率为100.1%,RSD=0.36%(n=9).结论:方法简便、准确、重复性好,可用于该制剂的含量测定.
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| 关 键 词： | 茶碱 高效液相色谱法 含量测定 |
| 收稿时间： | 2011/12/20 0:00:00 |
| 修稿时间： | 2012/3/19 0:00:00 |
Determination of Theophylline in Compound Dioxopromethazine Hydrochloride Tablets by RP-HPLC |
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| Sun Honggang,Wang Ying,Li Dongwei,Chen Xiaoqiang,Zhang Chunying,Cui Xuedan and Jia Shoushi.Determination of Theophylline in Compound Dioxopromethazine Hydrochloride Tablets by RP-HPLC[J].China Pharmacist,2012,15(6):824-825. |
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| Authors: | Sun Honggang Wang Ying Li Dongwei Chen Xiaoqiang Zhang Chunying Cui Xuedan and Jia Shoushi |
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| Institution: | Qiqihar the First Hospital, Heilongjiang Qiqihar 161005, China;;Qiqihar the First Hospital, Heilongjiang Qiqihar 161005, China;;Qiqihar the First Hospital, Heilongjiang Qiqihar 161005, China;;Qiqihar the First Hospital, Heilongjiang Qiqihar 161005, China;;Qiqihar the First Hospital, Heilongjiang Qiqihar 161005, China;;Qiqihar the First Hospital, Heilongjiang Qiqihar 161005, China;;Qiqihar Institute for Drug Control |
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| Abstract: | Objective: To establish a method for the determination of theophylline in compound dioxopromethazine hydrochloride tablets by HPLC.Method: The column was Kromasil-C18(250 mm×4.6 mm,5 μm).The mobile phase was water-methanol(65∶ 35).The flow rate was 1.0 ml·min-1 with the detection wavelength of 275 nm.Result: The linear range of theophylline was 0.107-5.335 μg·ml-1,r=0.999 7.The average recovery was 100.1% with RSD of 0.36%(n=9).Conclusion: The method is simple,accurate and repeatable. |
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| Keywords: | Theophylline HPLC Determination |
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