| 氟代香豆素的合成与抗肿瘤活性研究 |
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| 引用本文： | 于琛.氟代香豆素的合成与抗肿瘤活性研究[J].海峡药学,2012,24(5):265-267. |
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| 作者姓名： | 于琛 |
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| 作者单位： | 浙江嘉兴市中医医院,嘉兴,314000 |
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| 摘 要： | 目的 合成具有抗肿瘤活性的氟代香豆素.方法 以四氯化锡(摩尔分数为5%) 为催化剂,取代酚与三氟乙酰乙酸乙酯(物质的量比1∶1.2),通过Pechmann缩合反应,合成氟代香豆素衍生物,以MTT法检测其抗肿瘤活性.结果 合成得到6种氟代香豆素,其中化合物1、3、4具有较好的抗肿瘤活性.结论 6种氟代香豆素中的化合物1、3、4具有开发成为抗肿瘤药物的前景.
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| 关 键 词： | 三氟乙酸乙酯 取代酚 1H-NMR 抗肿瘤 |
Synthesis of fluorinated coumarins and characterization of its anti -tumor activity |
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| YU Chen.Synthesis of fluorinated coumarins and characterization of its anti -tumor activity[J].Strait Pharmaceutical Journal,2012,24(5):265-267. |
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| Authors: | YU Chen |
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| Institution: | YU Chen(Jiaxing Traditional Chinese Medicine Hospital Jiaxing,Zhejiang 314000,China) |
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| Abstract: | OBJECTIVE Synthesis of fluorinated coumarins of anti-tumor activity.METHODS Using tin tetrachloride(5mole%) as catalyst,substituted phenols and trifluoroacetyl ethyl acetate(molar ratio of 1∶1.2),through Pechmann condensation reaction,synthesize fluorinated coumarins derivatives and evaluate its anti-tumor activity with MTT method.RESULTS Synthesize six kinds of fluorinated coumarins,among which Compound 1,3 and 4 have good anti-tumor activity.CONCLUSION Compound 1,3 and 4 of six kinds of fluorinated coumarins,have the prospect for development into anticancer drugs. |
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| Keywords: | Ethyl trifluoroacetate Substituted phenols 1H-NMR Anti-tumor |
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