| HPLC法测定复方沙芬那敏糖浆含量的研究 |
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| 引用本文： | 江华.HPLC法测定复方沙芬那敏糖浆含量的研究[J].国际医药卫生导报,2009,15(8):67-69. |
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| 作者姓名： | 江华 |
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| 作者单位： | 广州白云山光华制药股份有限公司,510285 |
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| 摘 要： | 目的建立复方沙芬那敏糖浆中测定马来酸氯苯那敏和氢溴酸右美沙芬含量的方法。方法色谱柱为DiamondCls柱；流动相为甲醇-乙腈-0．005mol／L十二烷基磺酸钠溶液（含2％冰醋酸）（10：50：40）；流速为1．0ml／min，检测波长为254nm。结果本法测定马来酸氯苯那敏在20．2～161．6μg／ml、氢溴酸右美沙芬在26．4—211．2μg／ml浓度范围内，线性良好。结论方法准确可靠，简单易行，可用于该制剂的质量控制。
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| 关 键 词： | 复方沙芬那敏糖浆 马来酸氯苯那敏 氢溴酸右美沙芬 HPLC 含量测定 |
Measurement of Dextromethorphan Hydrochloride and Chlorphenamine Maleate Syrup by the HPLC method |
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| JIANG Hua.Measurement of Dextromethorphan Hydrochloride and Chlorphenamine Maleate Syrup by the HPLC method[J].International Medicine & Health Guidance News,2009,15(8):67-69. |
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| Authors: | JIANG Hua |
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| Institution: | JIANG Hua(Guangzhou hai yun shah guang hua Pharmaceutical Corporation, Guangzhou 510285,China) |
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| Abstract: | Objective HPLC method was established to determine the contents of chlorphenmine maleate and dextromethorphan hydrobromide in Dextromethorphan hydrobromide and Chlorphenamine Maleate Syrup.Methods The C18 column was used with Methanol-Acetonitrile-0.005mol/L Sodium Laurylsulfate(contained 2%acetic acid glacial)as the mobile phase.The detection wavelength was 254 nm.The flow rate was 1.0ml/min.Results A good linear relationships were obtained when the concentrations of chlorphenmine maleate were among 20.2 and 161.6μg/ml and that of dextromethorphan hydrobromide were among26.4and211.2μg/ml,respectively-Conclusion HPLC method was simple,accurate and highly sensitive and could be applied to the quatity control for Dextromethorphan Hydrochloride and Chlorphenamine Maleate Syrup. |
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| Keywords: | HPLC Chlorphenmine Male Dextromethorphan hydrobromide Dextromethorphan Hydroehloride and Chlorphenamine Maleate Syrup Determination HPLC |
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