| 人工虫草菌丝体提取物抗哇巴因所致心脏毒性作用的研究 |
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| 引用本文： | 季晖,龚晓健,卢顺高,曹祺,李绍平,李萍.人工虫草菌丝体提取物抗哇巴因所致心脏毒性作用的研究[J].中国药科大学学报,2000,31(2):40-42. |
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| 作者姓名： | 季晖 龚晓健 卢顺高 曹祺 李绍平 李萍 |
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| 作者单位： | 中国药科大学药理学教研室(季晖，龚晓健，卢顺高，曹祺)，生药学教研室!南京210009(李绍平，李萍) |
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| 摘 要： | 观察了人工虫草菌丝体石油醚及水提取物抗哇巴因所致豚鼠心脏毒性，并且通过测定ＳＯＤ及ＭＤＡ观察其抗菌自由基作用。结果表明石油醚提取物可显著提高哇巴因所致豚鼠心脏毒性和死亡剂量，可有效地增加ＳＯＤ活性及降低ＭＤＡ含量，提示本品可对抗哇巴因的心脏毒性和死亡剂量，可有效地增加ＳＯＤ活性及降低ＭＤＡ含量，提示本品可对抗哇巴因的心脏毒性，提高机体的抗氧化能力，未见水提物抗哇巴因所致豚鼠心脏毒性及抗氧自由基的作
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| 关 键 词： | 冬虫夏草 菌丝体 哇巴因 超氧化物歧化酶 |
Antagonistic Effects of Extracts from Cultural Mycelium of Cordyceps sinensis on Cardiotoxicity Induced by Ouabain |
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| JI Hui,GONG Xiao Jian,LU Shun Gao,CAO Qi,LI Shao Ping,LI Ping.Antagonistic Effects of Extracts from Cultural Mycelium of Cordyceps sinensis on Cardiotoxicity Induced by Ouabain[J].Journal of China Pharmaceutical University,2000,31(2):40-42. |
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| Authors: | JI Hui GONG Xiao Jian LU Shun Gao CAO Qi LI Shao Ping LI Ping |
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| Institution: | JI Hui,GONG Xiao Jian,LU Shun Gao,CAO Qi,LI Shao Ping 1,LI Ping 1 Department of Pharmacology,1Department of Pharmacognosy,China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | The antagonistic effects of extracts from cultural mycelium of Cordyceps sinensis on oxygen free radicals and cardiotoxicity induced by ouabain in guinea pigs were studied . The results showed that petroleum ether extract could significantly increase the dose of ouabain to induce cardiotoxicity, improve SOD activity and decrease MDA content. The results indicated that petroleum ether extract had the ability to antagonize toxicity induced by ouabain, while water extract had little effect on it. |
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| Keywords: | Cordyceps sinensis cultural mycelium ouabain SOD MDA Antagonistic effect |
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