抗心磷脂抗体与手术后深静脉血栓形成

目的 探讨抗心磷脂抗体（ACL抗体）在术后深静脉血栓形成（DVT）中的临床意义。方法 通过酶联免疫吸附法检测42例DVT患者的ACL抗体，其中22例为术后DVT患者，20例为无诱因DVT患者；另以44例健康体检者为对照组。结果 术后DVT患者的ACL抗体阳性率为27.3%，无诱因DVT患者的ACL抗体阳性率为55.0%，两者与正常对照组比较，差别均有显著性意义（P＜0.05及0.01）；在DVT患者中，ACL抗体与自发性流产和血小板减少症有明显相关性（均P＜0.05）。结论 对术前有血栓形成史、自发性流产史和不明原因血小板减少的患者有必要检测ACL抗体，阳性者术中、术后应给予抗凝剂以预防DVT的发生。

Anticardiolipin antibodies and postoperative deep venous thrombosis

Objective To study the clinic significace of anticardiolipin(ACL) antibodies in the patients of deep venous thrombosis(DVT).Methods Blood ACL antibodies were measured by ELISA in 22 patients of postoperative DVT and 20 patients of DVT without operation and 44 subjects under routine physical examination as controls.Results The postive rate of ACL antibodies was 27.3% in patients of postoperative DVT,55.0% in those of DVT without operation and 4.5% in controls respectively(P<0.025).ACL antibodies were closely related to spontaneous abortion or thrombocytopenia in DVT patients.Conclusions It is necessary to measure ACL antibodies before operation in the patients who had a history of thrombosis,spontaneous abortion or thrombocytopenia.And prophylactic anticoagulants should be gived pre_operatively to those who had a positive result of ACL antibodies.