| 氨溴索对急性肺损伤大鼠的抗氧化作用 |
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| 引用本文： | 梁雄.氨溴索对急性肺损伤大鼠的抗氧化作用[J].赣南医学院学报,2008,28(2):181-183. |
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| 作者姓名： | 梁雄 |
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| 作者单位： | 深圳市保安区人民医院呼吸内科,广东深圳,518101 |
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| 摘 要： | 目的：探讨急性肺损伤（ALI）大鼠模型超氧化物歧化酶（SOD）和丙二醛（MDA）的变化及氨溴索对ALI的保护作用。方法：将36只Wistar大鼠随机分成对照组、油酸模型组、氨溴索组3组。氨溴索组在注入油酸前30min腹腔内注入氨溴索50mg／kg。以上各组均在注油酸后4h采血测SOD，观察肺组织病理形态学变化，测定肺匀浆中MDA。结果：氨溴索组血清SOD含量2586±279KU／L与模型组血清SOD含量1898＋256KU／L比较明显增高（P〈0．01）；氨溴索组肺匀浆MDA含量（5．9±0．6nmol／m1）与模型组肺匀浆MDA（8．7±0．9nmol／m1）比较明显降低（P〈0．01）。病理组织学观察示氨溴索组肺组织病理改变较模型组减轻。结论：氨溴索对油酸致ALI大鼠模型有保护作用，这种保护作用可能与其抗氧化反应有关。
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| 关 键 词： | 急性肺损伤 氨溴索 超氧化物歧化酶 丙二醛 |
| 文章编号： | 1001-5779(2008)02-0181-03 |
| 修稿时间： | 2007年9月16日 |
Effect of ambroxol on oxidative stress in rats with acute lung injury |
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| LIANG Xiong.Effect of ambroxol on oxidative stress in rats with acute lung injury[J].Journal of Gannan Medical College,2008,28(2):181-183. |
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| Authors: | LIANG Xiong |
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| Institution: | LIANG Xiong (Bao An People\'s Hospital,Shenxhen Guangdong 518101) |
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| Abstract: | Objective：To explore the change of SOD or MDA and protective effects of ambroxol on acute lung injury （ALI） induced by oleicacid in rats. Methods：36 Wistar rats were randomly divided into 3 groups： normal control group, oleicacid model group, ambr- oxol treated group（ injected intraperitoneally with 2ml/kg ambroxol at 30 minutes before oleicacid injection）. The changes of SOD or MDA in blood and pathlolgichistology were observed. Results： Serum SOD levels in ambroxol treated group （2586 ~ 279KU/L） were markedly increased compared with oleicacid model group（ 1898±256KU/L）. Pulmonary tissue damages were diminished by pretreat- ment with ambroxol. Conclusion：It is suggested that ambroxol have protective effects on the acute hmg injury induced by oleicacid, which maybe correlated with the function that ambroxol can inhibite lipidperoxide. |
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| Keywords: | Acute lung injury Ambroxol SOD Malonaldehyde |
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