肠易激综合征患者外周血雌激素孕激素及睾酮激素含量分析

目的 检测肠易激综合征（irritable bowel syndrome，IBS）患者外周血中性激素水平，探讨IBS发病与外周血性激素的关系。方法 对符合罗马Ⅱ标准的48例IBS患者及30例健康对照者的外周血中雌激素、孕激素和睾酮激素的水平用放射免疫r计数器测定，并用自动软件分析。结果 对于男性IBS患者，其外周血中睾酮激素含量低于健康对照组（P〈0．05），而雌激素、孕激素含量与健康对照组差异无显著性（P〉0．05）。对于女性IBS患者，其外周血中雌激素含量低于健康对照组（P〈0．05），而孕激素、睾酮激素含量与健康对照组差星无显著性（P〉0．05）。结论 男性IBS患者外周血中睾酮激素含量下降，女性IBS患者外周血中雌激素含量下降，提示IBS患者的发病可能与体内性激素水平紊乱有关。

Association of peripheral blood estradiol, progesterone and testosterone levels with irritable bowel syndrome

OBJECTIVE: To investigate the relation of peripheral blood estradiol, progesterone and testosterone levels with irritable bowel syndrome (IBS). METHODS: Forty-eight patients with IBS identified according to Rome II diagnostic criteria and 30 healthy subjects as controls were analyzed for peripheral blood sex hormone levels by radioimmunoassay and corresponding software. RESULTS: In male patients with IBS, blood testosterone level was significantly lower than that of the control group (P<0.05), but blood estradiol and progesterone showed no significant differences between the two groups (P>0.05). In the female patients, blood estradiol level was significantly lower than that of the control group (P<0.05), whereas blood progesterone and testosterone levels had no significant differences between the two groups (P>0.05). CONCLUSION: Peripheral blood testosterone level in male IBS patients and estradiol level in female patients are lower than those of healthy subjects, suggesting that IBS might be associated with blood sex hormone disorder.