| 孕妇血清中HBV－DNA与乙型肝炎疫苗阻断母婴传播HBV的效果 |
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| 引用本文： | 邓新清,卢林耿,奚龙福,欧阳佩英,徐志一.孕妇血清中HBV－DNA与乙型肝炎疫苗阻断母婴传播HBV的效果[J].复旦学报(医学版),1994(2). |
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| 作者姓名： | 邓新清 卢林耿 奚龙福 欧阳佩英 徐志一 |
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| 作者单位： | 上海医科大学公共卫生学院流行病学教研室 |
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| 摘 要： | 血清ＨＢｓＡｇ、ＨＢｅＡｇ双阳性母亲的新生儿分别于出生时、１月龄、６月龄各接种１剂２０μｇ乙型肝炎（乙肝）疫苗后随访２ａ。随机抽取母婴乙肝病毒（ＨＢＶ）传播阻断成功的６４例、失败的２９例。用斑点杂交测定孕妇临产时血清ＨＢＶ－ＤＮＡ水平。结果表明疫苗阻断母婴传播成功组孕妇血清ＨＢＶ－ＤＮＡ水平明显低于失败组提示孕妇血清ＨＢＶ－ＤＮＡ水平高可能是疫苗阻断母婴传播失败原因之一。
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| 关 键 词： | 乙肝疫苗 HBV－DNA水平 母婴传播 Dig探计 斑点杂交 |
A PRELIMINARY STUDY ON THE RELATIONSHIP BETWEEN SERUM HBV-DNA LEVEL OF PREGNANT WOMEN AND EFFICACY OF HEPATITIS B VACCINE IN PREVENTION OF MOTHER-TO-INFANT TRANSMISSION |
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| Deng Xinqing,Lu Lingeng, Xi Longfu,Ou'yang Peiying,Xu Zhiyi.A PRELIMINARY STUDY ON THE RELATIONSHIP BETWEEN SERUM HBV-DNA LEVEL OF PREGNANT WOMEN AND EFFICACY OF HEPATITIS B VACCINE IN PREVENTION OF MOTHER-TO-INFANT TRANSMISSION[J].Fudan University Journal of Medical Sciences,1994(2). |
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| Authors: | Deng Xinqing Lu Lingeng Xi Longfu Ou'yang Peiying Xu Zhiyi |
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| Abstract: | |
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| Keywords: | hepatitis B vaccine HBV-DNA level mother-to-infant trans mission dig probe dot-hybridization |
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