载药妥布霉素人工骨（磷酸钙骨水泥）修复骨缺损的动物试验

目的 评价自固化磷酸钙骨水泥CPC（calcium phosphate cement)载药妥布霉素及植入兔体内后的CPC生物降解特性。方法 把CPC棒和妥布霉素CPC药棒植入兔股骨，观察其界面组织学等变化。结果 通过3个月观察，发现CPC棒和CPC药棒有部分被吸收现象，并且药棒中有新骨形成。结论 载药后的磷酸钙骨水泥仍然具有生物降解特性和骨转导作用。

An in Vivo Study of Tobramycin-Impregnated Calcium Phosphate Cement as an Artificial Bone Material Repairing Bone Defect

Purpose To evaluate the bidegradability of the tobramycin-impregnated self setting calcium phosphate cement (CPC) after planted into rabbits' bodies. Methods We observed the histological and other changes of the interface between bone and cement after CPC bars and drug loaded CPC bars were implanted into the femora of rabbits. Results Three months later the CPC and tobramycin loaded CPC were partially obsorbed and new bone formed in bars. Conclusions The drug doaded CPC has bidegradability and osteoconductivity functions.