| 亚低温对脑缺血/再灌注大鼠皮质内氨基酸 |
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| 引用本文： | 魏桂荣,胡波,梅元武,孙圣刚,童萼塘.亚低温对脑缺血/再灌注大鼠皮质内氨基酸[J].华中科技大学学报(医学版),2000,29(6):526-528. |
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| 作者姓名： | 魏桂荣 胡波 梅元武 孙圣刚 童萼塘 |
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| 作者单位： | 同济医科大学附属协和医院神经科，武汉 430022 |
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| 摘 要： | 采用大脑中动脉线栓模型，将63只Wistar大鼠随机分为假手术组、缺血组、亚低温组，后两者含缺血3h组及分别再灌注1h、2h、3h组。可见低温组谷氨酸（Glu）、天门冬氨酸（Asp）、丙二醛（MDA）的含量较缺血组明显减少，而超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）、γ-氨基丁酸（GABA）的含量明显增加。提示亚低温对氨基酸和自由基系统的影响是缺血脑保护的重要机制。
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| 关 键 词： | 亚低温 兴奋/抑制性神经递质 自由基 |
| 修稿时间： | 2000年1月3日 |
Effect of Mild Hypothermia on Aminoacids and Free Radical during Cerebral Ischemia-Reperfusion in Rat |
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| Wei Guirong,Hu Bo,Mei Yuanwu et al.Effect of Mild Hypothermia on Aminoacids and Free Radical during Cerebral Ischemia-Reperfusion in Rat[J].Journal of Huazhong University of Science and Technology(Health Sciences),2000,29(6):526-528. |
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| Authors: | Wei Guirong Hu Bo Mei Yuanwu |
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| Institution: | Wei Guirong,Hu Bo,Mei Yuanwu et al Department of Neurology Xieke Hospitol,Tongji Medical University,Wuhan 430022 |
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| Abstract: | Sixty-three Wistar rats were divided randomly into nine groups: control group, ischemia groups including subgroups of ischemia (is) - h, is-3h/reperfusion (rep) -1h, is-3h/rep-2h, is-3h/rep-3h (n= 7 in each group), mild hypothermia groups including subgroups of is-3h, is-3h/rep-1h, is-3h/rep-2h, is- 3h/rep-3h (n=7 in each group) with Zea longa's animal model of cerebral artery occlusion. It was found that the contents of glutamate, aspartate, MDA in cerebral cortex were significantly lower, but the contents of GABA, SOD and GSH-PX obviously higher in mild hypothermia groups than in the ischemia groups. It was suggested that the change of contents of four types of animo acids and free radial system by mild hypothermia is an important protective mechanism to ischemia neurons. |
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| Keywords: | mild hypothermia excitory/inhibitory animo acids free radicals |
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