环磷酰胺对家兔动脉粥样硬化的影响

将21只雄性大白兔随机等分成3组环磷酰胺组(A组)、动脉粥样硬化对照组(B组)和正常对照组(C组),观察免疫抑制剂环磷酰胺对高脂血症动物的血脂、抗体、补体以及动脉粥样硬化(atherosclerosis,AS)病变的影响.实验结束时发现A、B两组的血脂、抗体、补体及循环免疫复合物(CIC)水平明显高于C组;A、B两组血脂水平相比无明显差异,但免疫指标相比有明显差异;A组的主动脉斑块面积和主动脉内膜厚度明显小于B组(P<0.01).本实验提示AS的发生与免疫反应有关,环磷酰胺可以减轻兔主动脉粥样斑块的形成,但不是通过降血脂途径.

Effect of Cytoxan on Atherosclerosis in Rabbits

Twenty male rabbits were randomly divided into three groups: cytoxan(CTX) group (A), atherosclerosis (AS) control group (B) and negative control group (C). The effects of the serum lipids, immunoglobulin, circulating-immuno-complex (CIC) and complement on AS in the rabbits with hyperlipemia were observed. It was found that the levels of serum lipids, immunoglobulin, CIC and complement in the groups A and B were significantly higher than in the group C. No significant difference was found in the levels of serum lipids, but there was significant difference in immunoglobulin, CIC and complement between groups A and B. Both the area of aorta flecks and the intimal thickness in the group A were less than in the group B (P<0.01). It was suggested that the occurrence of AS had relation with immune response. CTX could slow down the formation of AS in rabbits, but not by reducing the level of serum lipids.