注射用蒺藜皂苷对麻醉开胸犬急性心肌梗塞的保护作用

目的：研究注射用蒺藜皂苷(GSTT)对麻醉开胸犬结扎冠脉所致急性心肌梗塞的保护作用。 方法：取杂种犬30只，随机分为5组（每组6只），分别为空白对照组、血塞通（阳性对照药物）组及GSTT 6.26、12.52 和25.0 mg•kg^-1剂量组；结扎左冠状动脉前降支，制备急性心肌梗塞模型，观察GSTT对心外膜电图（EECG）、心肌梗塞范围和血清心肌酶的影响。 结果：GSTT各剂量组与空白对照组比较心肌缺血程度减轻(P<0.05)，缺血范围缩小(P<0.05)，血清酶降低(P<0.01),心肌梗塞面积缩小(P<0.001)。 结论：GSTT对麻醉开胸犬急性心肌梗塞的心肌缺血具有明显的保护作用。

Protective effects of Gross Saponin of Tribulus Terrestris on anaesthetic thoraco-opened dogs with acute myocardial infarction

Objective To study the effects of Gross Saponin of Tribulus Terrestris (GSTT) on acute myocardial infarction induced by ligating coronary artery in anaesthetic thoraco-opening dogs by injection. Methods Thirty domestic dogs were randomly divided into 5 groups (6 in each group): blanking control group, positive control group(Xuesaitong), GSTT groups with doses of 6.26 , 12.52, and 25.0 mg·kg -1, respectively. The descending branch of left coronary artery was ligated to construct the model of acute myocardial infarction. The effects of GSTT on epicardium electrocardiogram(EECC), myocardial infarction range(MIS) , and serum myocardium enzyme were observed. Results The ischemia degree(Σ-ST, P<0.05) and the ischemia area(N-ST, P<0.05) were reduced in GSTT groups with various doses compared with controls. In addition, GSTT reduced the serum myocardium enzyme levels (P<0.01) and myocardial infarction ranges(P<0.001) compared with controls. Conclusion GSTT can significantly protect ischemic myocardium of the anesthetic thoraco-opening dogs mediated by ligating coronary artery.