HBIG联合乙肝疫苗阻断HBV母婴传播的效果研究

目的 观察HBIG联合乙肝疫苗阻断HBV母婴传播的临床效果.方法 将138名HBsAg、HBeAg双阳性的母亲及所生的新生儿按不同的阻断方法随机分为3组,在新生儿及婴儿12个月龄时,采血清检测HBsAg和抗-HBs,并对结果进行统计分析.结果 研究Ⅱ组和对照组新生儿HBsAg阳性率分别为2.22%和26.53%,差异具有显著性（P＜0.005）;研究Ⅱ组和对照组新生儿抗-HBs阳转率分别为31.11%和8.16%,差异有显著性（P＜0.005）;研究Ⅰ组、研究Ⅱ组和对照组的12月龄婴儿HBsAg阳性率分别为6.82%、2.22%和26.53%,差异有统计学意义（P＜0.005）;研究Ⅰ组、研究Ⅱ组和对照组的12月龄婴儿抗-HBs阳转率分别为79.55%、73.33%和65.31%,差异无统计学意义（P＞0.05）.结论 乙肝免疫球蛋白与乙肝疫苗联合免疫阻断母婴垂直传播的效果优于单独接种乙肝疫苗.

Observation on the results of HBIG combined with hepatitis B vaccine in terruption of vertical transmission of HBV

Objective To observe the results of hepatitis B immunoglobulin(HBIG)combined with Hepatitis B vaccine in interrupting the vertical transmission of hepatitis B from mothers to babies.Methods There 138 mothers(and their newborns)positive for HbsAg and HbeAg were divided into observation group I,observation group II and control group,the serum samples were collected and detected before observation and 12 months after the birth of the babies.Results The positive rates of newborns born by mothers in observation group II and control group were 2.22% and 26.53%,respectively,showing significant difference(P<0.005).The positive conversion rates of anti-HBs in observation group II and control group were 31.11% and 8.16%,respectively,showing significant difference(P<0.005).The positive rates of HbsAg of the newborns aged 12 months in observation group I,observation group II and control group were 31.11%,2.22% and 26.53%,respectively,also showing significant differences(P<0.05).The positive conversion rates of the newborns aged 12 months old in observation group I,observation group II and control group were 79.55%,73.33% and 65.31%,without showing significant differences(P>0.05).Conclusion The effect of HBIG in combination with hepatitis B vaccine is superior to use of hepatitis B vaccine alone in interrupting vertical transmission hepatitis B from mothers to their babies.