缺氧性脑病3例临床病理报告

三例不同病因所致缺氧性脑病的尸检材料表明脑部损害共同性的神经病理改变是急性缺血性神经元改变,普金野细胞尼氏体溶解或消失及胶质反应。选择性的改变:苏满氏段锥体细胞消失仅见死于癫痫连续状态的病人。每例皮质中均可找到弥散性急性神经元肿胀变化,为可逆性的,如及时认识及适当治疗,有益于防止神经细胞死亡。

HYPOXIC ENCEPHALOPATHY, A CLINICOPATHOLOGICAL REPORT OF 3 CASES

Three autopsied cases of hypoxic encephalopathy resulted from different etiology are reported. The causes of brain damage were open-heart surgery, status epilepticus or suicidal hanging respectively. The common neuro- pathologic changes were acute ischemic neuronal change in the cerebral cortex, chromatolysis or disapperance of the Purkinje's cells and glial reaction. The selective change-loss of pyramid cells of the Sommer sector was only found in the patient who died of status epilepticus. Diffused acute neuronal swelling changes could be found in the cortex of each case. It's considered that prompt recognition and appropriate therapy will be helpful in preventing the nerve cells from death.