益肾活血胶囊对同型半胱氨酸血症实验大鼠的影响

目的：观察益肾活血胶囊对同型半胱氨酸（Homocysteine,Hcy）血症大白鼠血液生化及细胞因子的影响.方法：将80只Wistar大鼠分为模型组、正常组、大剂量益肾活血胶囊组、小剂量益肾活血胶囊组、西药（叶酸、维生素B12、维生素B6）组、大黄蛰虫丸组、预防组、空白组共8组,除正常组外,其他组大鼠建立同型半胱氨酸血症大白鼠模型,分别对各组大鼠血液Hcy、内皮素（ET）、一氧化氮（NO）、超氧化物歧化酶（SOD）、丙二醛（MDA）、抗凝血酶-Ⅲ（AT-Ⅲ）进行检测,观察大鼠造模前后的变化,以检测各组药物的有效性.结果：益肾活血胶囊降低实验大鼠Hcv水平,与西药组相似,优于大黄蛰虫丸组;降低ET、MDA水平,升高NO、AT-Ⅲ、SOD水平,优于西药组及大黄蛰虫丸组.结论：益肾活血胶囊具有降低Hcv的作用,并能改善血管内皮细胞功能、抗凝、抗氧化,为临床治疗血管性疾病提供了依据.

Effects of yishenhuoxue capsule on hyperhomocysteinemia in rats

Objective:To observe the role of yishenhuoxue capsule on hyperhomocysteinemia in rats.Methods: Eighty Wistar rats were randomized into 8 groups,model,normal,large dose of yishenhuoxue capsule,small dose of yishenhuoxue capsule,Western medicine(folic acid,VitB12,VitB6),dahuangzhechong pill,prevention and blank groups.Excluding in normal,hyperhomocysteinemia model was established in other groups.The blood Hcy,ET,NO,SOD,MDA and AT-III were measured.Results: The level of Hcy declined in both yishenhuoxue capsule and Western medicine groups.The level of ET and MDA decreased and the level of SOD,AT-III and NO increased in yishenhuoxue capsule group,which was superior to others.Conclusion: Yishenhuoxue capsule has important role in reducing the level of Hcy and in improving the endothelial cell function,anticoagulatory,anti-oxidant of blood vessel,offering the basis for treating blood vessel diseases.