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| 应用组织芯片技术检测结直肠癌组织中KAI1/CD82和ME491/CD63的表达 | |
| 引用本文： | 季润元,史恩溢,王永实,李小宁,赵玉芳,冯振卿.应用组织芯片技术检测结直肠癌组织中KAI1/CD82和ME491/CD63的表达[J].中国医科大学学报,2012,41(10):941-944. |
| 作者姓名： | 季润元 史恩溢 王永实 李小宁 赵玉芳 冯振卿 |
| 作者单位： | 1. 江苏省淮阴卫生高等职业技术学校,淮安市消化道肿瘤重点实验室,江苏淮安223300 2. 江苏省苏州卫生职业技术学院病理教研室,江苏苏州,215009 3. 江苏省淮安市肿瘤医院病理科,江苏淮安,223200 4. 南京医科大学病理学系,南京,210029 |
| 基金项目： | 江苏省卫生厅医学科技发展基金立项(J201116) |
| 摘 要： | 目的 研究结直肠癌组织中KAI1/CD82和ME491/CD63的表达水平及其临床病理意义.方法 应用组织芯片和免疫组织化学技术检测232例结直肠癌组织中KAI1/CD82和ME491/CD63的表达,并运用统计学方法分析KAI1/CD82和ME491/CD63的表达与结直肠癌各种临床病理特征的关系及两者的相关性.结果 KAI1/CD82在结直肠癌组织中的表达与肿瘤的分化程度和Dukes分期有关(P＜0.05),与患者的性别、年龄、浸润深度、淋巴结转移无关(P＞0.05).未发现ME491/CD63表达与结直肠癌病理资料之间差异有统计学意义(P＞0.05).KAI1/CD82和ME491/CD63的表达差异有统计学意义(P＜0.05).结论 KAI1/CD82在结直肠癌组织中的表达与肿瘤临床病理特征密切相关,可作为结直肠癌的预后因子.KAI1/CD82和ME491/CD63的表达相关. |
| 关 键 词： | 结直肠癌 KAI1/CD82 ME491/CD63 组织芯片 免疫组织化学 相关性 |
Detection of KAI1/CD82 and ME491/CD63 Expression in Colorectal Carcinoma Using Tissue Microarrays |
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| JI Run-yuan , SHI En-yi , WANG Yong-shi , LI Xiao-ning , ZHAO Yu-fang , FENG Zhen-qing.Detection of KAI1/CD82 and ME491/CD63 Expression in Colorectal Carcinoma Using Tissue Microarrays[J].Journal of China Medical University,2012,41(10):941-944. | |
| Authors: | JI Run-yuan SHI En-yi WANG Yong-shi LI Xiao-ning ZHAO Yu-fang FENG Zhen-qing |
| Institution: | 1.Huaiyin Advanced Vocational and Technical Hygiene School;Huaian Key Lab of the Tumor of Digestive System,Huaian 223300,China;2.Department of Pathology,Jiangsu Province Suzhou Health College,Suzhou 215009,China;3.Department of Pathology,Cancer Hospital of Huaian City,Huaian 223300,China;4.Department of Pathology,Nanjing Medical University,Nanjing 210029,China) |
| Abstract: | Objective To study the expression levels of KAI1/CD82 and ME491/CD63 and the clinicopathological significances in colorectal carcinoma.Methods Tissue microarray and immunohistochemistry were used to detect the expression of KAI1/CD82 and ME491/CD63 in 232 cases of colorectal carcinoma.The correlation between KAI1/CD82 and ME491/CD63 expression as well as the clinical and pathological characteristics were analyzed using statistical method.Results The expression of KAI1/CD82 correlated with the tumor differentiation degree and Dukes stages(P < 0.05),but not with the patients′ gender,age,depth of infiltration,or lymphnode metastasis(P > 0.05).No correlation was found between the expression of ME491/CD63 in colorectal carcinoma and it′s clinicopathological data(P > 0.05).Significant correlation was found between the expression of KAI1/CD82 and ME491/CD63(P < 0.05).Conclusion The expression of KAI1/CD82 is closed correlated with clinicopathological significance of the tumor,which can be used as a prognostic factor for colorectal carcinoma.The expression of KAI1/CD82 significantly correlate with the expression of ME491/CD63. |
| Keywords: | colorectal carcinoma KAI1/CD82 ME491/CD63 tissue microarray immunohistochemistry correlation |
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