| 姜黄素类化合物的抗肿瘤活性 |
| |
| 引用本文： | 王玉玲,吴振,张喜轩.姜黄素类化合物的抗肿瘤活性[J].中国医科大学学报,2006,35(4):380-381. |
| |
| 作者姓名： | 王玉玲 吴振 张喜轩 |
| |
| 作者单位： | 1. 中国医科大学基础医学院化学教研室,辽宁,沈阳,110001
2. 黑龙江大学化学化工学院有机教研室 |
| |
| 摘 要： | 目的：研究姜黄素类化合物诱导HeLa细胞凋亡及其构效关系。方法：MTT法、Hoechst染色法、DNA凝胶电泳法。结果：姜黄素类化合物可抑制HeLa细胞的生长，诱导HeLa细胞凋亡；琼脂糖凝胶电泳可见典型的DNA带状泳道。结论：姜黄素类化合物可明显地诱导HeLa细胞凋亡，且与其结构有密切关系。
|
| 关 键 词： | 抗癌药 姜黄素 活性 |
| 文章编号： | 0258-4646(2006)04-0380-02 |
| 收稿时间： | 2005-07-12 |
| 修稿时间： | 2005年7月12日 |
Anti-tumor activity of curcumin-related compounds |
| |
| WANG Yu-ling,WU Zhen,ZHANG Xi-xuan.Anti-tumor activity of curcumin-related compounds[J].Journal of China Medical University,2006,35(4):380-381. |
| |
| Authors: | WANG Yu-ling WU Zhen ZHANG Xi-xuan |
| |
| Institution: | 1. Department of Chemistry, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China; 2. College of Chemistry, Heilongjiang University |
| |
| Abstract: | Objective: To study the HeLa cell apoptosis induced by curcumin-related compounds and the activity-structure relationship of this compound.Methods: MTT method,morphological observation,agarose gel electrophoresis were performed in this study.Results: Curcumin-related compounds inhibited the growth and induced the apoptosis of HeLa cells.Marked morphological changes,including condensed chromatin,nuclear fragmentation,apoptotic bodies,and DNA ladder in agarose gel,were observed.Conclusion: Curcumin-related compounds could inhibit the apoptosis of HeLa cells,which is correlated with its structure. |
| |
| Keywords: | anti-tumor agent curcumin activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
