152例乳腺癌腋窝淋巴结转移规律的临床研究

目的探讨乳腺癌腋窝淋巴结转移与肿瘤大小、位置、病理性质、ER、PR、HER-2基因表达以及患者年龄之间的关系、规律，以明确各因素在乳腺癌腋窝淋巴结转移中的决定地位，为临床乳腺癌根治性手术中腋窝淋巴结清扫术的指征提供理论依据。方法应用logistic回归方程分析2005.11-2007.10间152例乳腺癌患者腋窝淋巴结转移情况，筛选出危险因素并对每个危险因素进行分析。结果152例乳腺癌患者中，腋窝淋巴结存在转移者74例（48.7%），筛选出肿瘤大小、生长部位、病理性质为腋窝淋巴结转移的危险因素，而腋窝淋巴结转移与否与患者的年龄、肿瘤ER、PR、HER-2基因的表达没有关系。结论乳腺癌腋窝淋巴结转移主要是由多因素决定的，不应以某一因素作为乳腺癌手术中放弃腋窝淋巴结清扫的依据。

Clinical research on 152 axillary lymph node metastasis of breast cancer

Objective： To explore the relationship between axillary lymph node metastasis of breast cancer and tumor size, location, pathological nature, ER, PR, HER-2 gene expression and the patient＇s age, to clear the factors in breast cancer axillary lymph node status of the transfer of the decision for clinical radical breast cancer surgery in axillary lymph node dissection of the indications and provide a theoretical basis. Methods ： Logistic regression equation was applied to analyze 152 axillary lymph node metastases in patients with breast cancer between 2005.11 and 2007.10; risk factors were selected and each of the risk factors was screened for analysis. Results： Among the 152 patients with breast cancer, the presence of axillary lymph node metastasis was 74 cases （48.7%） ; and tumor size, growth location, pathological nature were the risk factors for axillary lymph node transfer and axillary lymph node metastasis had nothing to do with patients＇age, tumor ER, PR, HER-2 gene expression. Conclusion： The axillary lymph node metastasis of breast cancer is caused by a number of factors, so we should not decide whether or not to give up the axillary lymph node dissection in the breast cancer surgery on the basis of one factor only.