| Effect of anisodamine on changes of blood-brain barrier permeability following brain injury in rabbits |
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| 作者姓名： | 徐如祥 易声禹 王伯云 |
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| 作者单位： | Department of Neurosurgery Zhujiang Hospital，First Military Medical University，Guangzhou 501282，Department of Neurosurgery，Xijin Hospital，Fourth Military Medical University，Xi'an 710032，Department of Neurosurgery，Xijin Hospital，Fourth Military Medical University，Xi'an 710032 |
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| 摘 要： | The changes of blood-brain barrier(BBB)permeability following brain injury werestudied quantitatively by using colloidal gold(CG)particles of various sizes as tracers in 57 rab-bits.In addition,water content in brain tissues was determined.The brain-injured rabbits re-ceived intravenous injection of anisodamine in a dose of 0.3 mg/kg BW at 5rain or 3h after braininjury,and the effect of anisodamine on aherations of BBB permeability and water content of thebrain tissue after brain injury was investigated.The results indicated that an increase of BBBpermeability began at 30min after injury with only a few of 5nm CG tracers present in the endo-cytic pits and endothelial microvilli,and there were 10nm CG tracers passing through the BBB at3 h after brain injury.The increase of BBB permeability reached its peak at 6 h after brain in-jury.More 15nm CG tracers penetrated the BBB by way of pinocytotic vesicule transportationand opening of tight junctions between endothelial cells.The water content in the brain tissueincreased,which was closely correlated to the above-mentioned EBB permeability and giving ad-vantages to the treatment of traumatic brain edema in the present study.
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Effect of anisodamine on changes of blood-brain barrier permeability following brain injury in rabbits |
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| Xu Ruxiang,Yi Shengyu,Wang Boyun.Effect of anisodamine on changes of blood-brain barrier permeability following brain injury in rabbits[J].Journal of Medical Colleges of PLA(China),1992(3). |
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| Authors: | Xu Ruxiang Yi Shengyu Wang Boyun |
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| Institution: | Xu Ruxiang,Yi Shengyu,Wang Boyun Department of Neurosurgery,Zhujiang Hospital,First Military Medical University,Guangzhou 501282 Department of Neurosurgery,Xijin Hospital,Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | The changes of blood-brain barrier(BBB)permeability following brain injury were studied quantitatively by using colloidal gold(CG)particles of various sizes as tracers in 57 rab- bits.In addition,water content in brain tissues was determined.The brain-injured rabbits re- ceived intravenous injection of anisodamine in a dose of 0.3 mg/kg BW at 5rain or 3h after brain injury,and the effect of anisodamine on aherations of BBB permeability and water content of the brain tissue after brain injury was investigated.The results indicated that an increase of BBB permeability began at 30min after injury with only a few of 5nm CG tracers present in the endo- cytic pits and endothelial microvilli,and there were 10nm CG tracers passing through the BBB at 3 h after brain injury.The increase of BBB permeability reached its peak at 6 h after brain in- jury.More 15nm CG tracers penetrated the BBB by way of pinocytotic vesicule transportation and opening of tight junctions between endothelial cells.The water content in the brain tissue increased,which was closely correlated to the above-mentioned EBB permeability and giving ad- vantages to the treatment of traumatic brain edema in the present study. |
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| Keywords: | brain injury blood-brain barrier colloidal gold anisodamine |
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