| 益肾降浊汤对大鼠脑缺血再灌注 SOD活性和MDA含量的影响* |
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| 引用本文： | 孟凡星,高维娟,袁国红,郎志峰.益肾降浊汤对大鼠脑缺血再灌注 SOD活性和MDA含量的影响*[J].承德医学院学报,2001,18(1):7-8. |
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| 作者姓名： | 孟凡星 高维娟 袁国红 郎志峰 |
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| 作者单位： | 承德医学院病理生理学教研室, |
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| 基金项目： | 河北省科技厅科研项目;98276187D; |
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| 摘 要： | 目的：观察益肾降浊汤对大鼠脑缺血再灌注致脑损伤模型中脑组织内SOD活性和MDA含量的影响。方法：在药物致大鼠低血压的基础上建立缺血再灌注致脑损伤模型，用益肾降浊汤灌胃，连续七天，每天一次，末次灌胃后60min大鼠断头取脑。用羟胺法测SOD活性，TBA法测MDA含量。结果：与模型组比较，益肾降浊汤能明显提高脑组织内SOD活性和MDA含量（P＜0．05）。结论：益肾降浊汤有一定的抗脑缺血再灌注致脑损伤的作用。
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| 关 键 词： | 益肾降浊汤 缺血再灌注 SOD MDA 脑缺血 中医药疗法 |
| 文章编号： | 1004-6879(2001)01-0007-02 |
| 修稿时间： | 2000年10月25日 |
INFLUENCE OF YISHEN JIANGZHUO DECOCTION ON SOD ACTIVITIES AND MDA CONTENTS IN RATS OF CEREBRAL ISCHEMIA-REPERFUSIN |
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| MENG Fan xing,et al.INFLUENCE OF YISHEN JIANGZHUO DECOCTION ON SOD ACTIVITIES AND MDA CONTENTS IN RATS OF CEREBRAL ISCHEMIA-REPERFUSIN[J].Journal of Chengde Medical College,2001,18(1):7-8. |
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| Authors: | MENG Fan xing |
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| Abstract: | Objective:To investigate the effect of Yishen Jiangzhuo decoction on superoxide dismutase(SOD) activities and malondialdehyde(MDA) contents in rats with injury of cerebral ischemiareperfusion.Methods:After the model of ischemia reperfusion injury was performed based on hypotension,the rats were administed ig with Yishen Jiangzhuo decoction once a day for seven days.After the last ig 60 minusts,the rats were all decapitated and extract the brain to assay SOD activities and MDA contents.Results:Yishen Jiangzhuo decoction can significantly increase SOD activities and decrease MDA contents compared with model group.Conclusion:Yishen Jiangzhuo decoction in a degree have the effect of antagonized the cerebral ischemia reperfusion injury. |
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| Keywords: | Yishen Jiangzhuo decoction Brain Ischemia reperfusion SOD MDA |
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