巨细胞病毒与动脉粥样硬化的临床研究

目的 研究巨细胞病毒和动脉粥样硬化的关系。方法 用ＰＣＲ的方法检查巨细胞病毒在颈内动脉、冠状动脉和血中的分布情况，并与健康人对照。结果 ８３．３％～８６．７％的动脉粥样硬化患者的动脉壁中存在巨细胞病毒，而非动脉粥样硬化患者的动脉壁中只有６．７％的标本中见巨细胞病毒，两者相差有高度显著性（Ｐ〈０．０１）；在４２．４％的动脉粥样硬化患者的血中查见世细胞病毒，而对照组中只有３％查到巨细胞病毒，两者相差有

CLINICAL STUDY OF CYTOMEGALOVIRUS AND ATHEROSCLEROSIS

Objective To study the association of cytomegalovirus (CMV) with atherosclerosis.Methods CMV was detected by polymerase chain reaction (PCR) and its distribution in carotid artery and coronary artery as well as in the blood was examined, which was compared with control subjects.Results 83.8%~86.7% of the samples obtained from atherosclerotic patients' arterial walls were shown to contain viral nucleic acid (CMV), while CMV could be found only in 6.6% of the patients' arterial walls without atherosclerosis. The difference was statistically significant (P<0.01). CMV was found in blood among 42.4% of the patients with atherosclerosis, while only 3% of the samples in the control group had CMV with significant difference again (P<0.01).Conclusion CMV plays an important role in the pathological process of the atherosclerosis and the atherosclerotic cerebral infarction