| 拉米夫定治疗102例慢性重度乙型肝炎近期疗效观察 |
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| 引用本文： | 胡章勇,杨军,黄赛,夏绍碧,刘福元.拉米夫定治疗102例慢性重度乙型肝炎近期疗效观察[J].四川医学,2011,32(5):661-662. |
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| 作者姓名： | 胡章勇 杨军 黄赛 夏绍碧 刘福元 |
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| 作者单位： | 成都医学院第一附属医院感染科,四川,成都,610500 |
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| 摘 要： | 目的探讨拉米夫定抗病毒治疗对慢性重度乙型肝炎预后的影响。方法将197例慢性重度乙肝患者随机分为治疗组和对照组,对照组接受综合护肝治疗措施,治疗组在此基础上,服用拉米夫定100mg/d,治疗8周。结果在治疗第8周,治疗组谷丙转氨酶、总胆红素及血清HBV DNA的下降水平明显优于对照组（P〈0.01）;凝血酶原活动度较治疗前显著升高,但以治疗组更为明显;在治疗组中,重型肝炎的发生率、病死率和并发症的发生率均显著低于对照组。结论拉米夫定能在短期内阻断部分慢性重度乙型肝炎进展,提高存活率,减少并发症发生率。
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| 关 键 词： | 慢性重度乙型肝炎 DNA病毒 治疗 拉米夫定 |
Short-term efficacy of lamivudine for 102 patients with chronic severe-degree hepatitis B |
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| HU Zhang-yong,YANG Jun,HUANG Sai,et al..Short-term efficacy of lamivudine for 102 patients with chronic severe-degree hepatitis B[J].Sichuan Medical Journal,2011,32(5):661-662. |
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| Authors: | HU Zhang-yong YANG Jun HUANG Sai |
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| Institution: | HU Zhang-yong,YANG Jun,HUANG Sai,et al.The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan 610500,China |
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| Abstract: | Objective To evaluate the effect of lamivudine for patients with chronic severe-degree hepatitis B.Methods 197 patients with chronic severe-degree hepatitis B were randomly divided into a conventional supporting treatment control group and a lamivudine treatment group.In the latter,102 patients were given lamivudine orally at a dose of 100mg every day besides the support care which was also given to the control group.Results After therapy for 8 weeks,total bilirubin and alanine aminotransferase levels of la... |
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| Keywords: | chronic hepatitis B DNA virus treatment lamivudine |
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