| 苦参素对实验性肝纤维化的干预作用 |
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| 引用本文： | 鄂裘恺,郁林曦,朱歆鑫,张慎彦,罗琳,周鸣鸣,鄂群.苦参素对实验性肝纤维化的干预作用[J].南通医学院学报,2009,29(2). |
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| 作者姓名： | 鄂裘恺 郁林曦 朱歆鑫 张慎彦 罗琳 周鸣鸣 鄂群 |
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| 作者单位： | 南通大学生命科学学院,南通,226007 |
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| 摘 要： | 目的:观察苦参素对四氯化碳(CCl4)诱导的实验性肝纤维化的干预作用。方法:将SD大鼠分成正常对照组、模型组、苦参素小剂量治疗组(40mg/kg)、中剂量治疗组(80mg/kg)、大剂量治疗组(160mg/kg),造模4周后苦参素治疗至实验第10周,取血测相关血清学指标,计算肝脏指数,测定肝组织匀浆中HYP和MDA含量。结果:苦参素能降低肝纤维化大鼠血清丙转氨酶(ALT)、谷草转氨酶(AST)、胆汁酸(TBA)、γ-谷氨酰转移酶(GGT)和肝脏指数,同时能减少肝组织中羟脯氨酸(HYP)和MDA含量(P<0.05或P<0.01)。结论:苦参素具有抗CCl4诱导的实验性肝纤维化的作用。
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| 关 键 词： | 肝纤维化 细胞外基质 大鼠 苦参素 四氯化碳 |
Preventive effect of Kushenin on formation of experimental hepatic fibrosis in rats |
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| E Qiukai,YU Linxi,ZHU Xinxin,et al.Preventive effect of Kushenin on formation of experimental hepatic fibrosis in rats[J].ACTA Academiae Medicinae Nantong,2009,29(2). |
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| Authors: | E Qiukai YU Linxi ZHU Xinxin |
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| Institution: | School of Life Science;Nantong University;Nantong 226007 |
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| Abstract: | Objective:To investigate the intervention effect of oxymatrine on experimental liver fibrosis induced by carbon tetrachloride(CCl4) in rats. Methods: Sprague-Dawley (SD) 50 rats were randomly divided into 5 groups: the normal control group, model control group without treatment, model with oxymatrine treatment of low dose (40 mg·kg-1), middle dose(80 mg·kg-1) and high dose group (160 mg·kg-1). The rat liver fibrosis model was prepared by administration of CCl4. In the development of fibrosis, oxymatrine was... |
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| Keywords: | Liver fibrosis Extracellular matrix Rat Oxymatrine Carbon tetrachloride |
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