进展期胃癌患者行术前动脉介入化疗对肝脏微环境的影响

目的：观察进展期胃癌患者行新辅助化疗后的肝脏微环境的变化，评估术前动脉介入化疗的安全性。方法：收集小于70岁的胃癌患者60例，随机入组分为对照组、术前动脉介入化疗组和术前静脉化疗组，入院后常规检查肝功能，化疗后第1、3、7天抽取外周血了解化疗药物对肝脏功能的影响，术中收集正常肝组织观察术前新辅助化疗对肝脏结构的改变。结果：与术前静脉化疗组相比较，术前动脉介入化疗组光镜及电镜下肝脏细胞结构变化无显著差异，两组肝功能均在正常范围内；治疗组与对照组相比较，肝脏细胞结构发生变化，治疗后肝功能轻度异常。结论：术前动脉介入化疗后，患者肝功能及肝脏微结构无明显异常。

Changes of liver microenvironment on advanced gastric cancer patients undergoing preoperative regional artery chemotherapy

Objective： To study the changes of liver microenvironment in patients with gastric cancer after preoperative regional artery chemotherapy , evaluate the safety of preoperative arterial interventional chemotherapy . Methods：Sixty patients with gastric cancer were collected , which less than 70-year-old.Patients were divided into control group , preoperative regional artery chemotherapy group and preoperative intravenous chemotherapy group , during the surgery we collected gastric carcinoma tissues and normal liver tissue .The changes of cancer tissue and the liver structure were observed .The expressions of C-Met/HGF were detected .Implementation chemotherapy of the first, third and seventh days , peripheral venous blood was respectively collected , which in order to understand the effects of chemotherapy drugs on liver function .Results： By comparison to preoperative intravenous chemotherapy group, in the preoperative regional artery chemotherapy group , tumor necrosis was obviously , the liver structure changes had no significant differences under the light microscope and electron microscope , liver functions were within the normal ranges .The treatment group compared with control group , liver cell structure changed , mild abnormal liver function after treatment .Conclusion： Patients with preoperative arterial interventional chemotherapy have no obvious abnormal liver function and liver microstructure .