脑梗死患者颅内外动脉粥样硬化性狭窄及影响因素分析

目的 分析脑梗死患者颅内外动脉粥样硬化性狭窄的分布情况,探讨动脉粥样硬化危险因素与病变部位的关系.方法 搜集2008年7月至2010年6月间在北京大学人民医院神经内科住院的由经颅多普勒、颈动脉彩色超声、颅内磁共振血管成像和数字减影血管造影诊断存在颅内和(或)颅外动脉粥样硬化性狭窄的428例脑梗死患者资料,根据血管病变部位分组,比较各组间动脉粥样硬化危险因子的差别.结果 颅内动脉病变组199例(46.5%),颅外动脉病变组129例(30.1%),颅内合并颅外动脉病变组100例(23.4%);颅内动脉病变组总胆固醇(TC)、低密度脂蛋白胆固醇酯(LDL-C)水平高于其他两组(TC:P1=0.001,P2=0.000;LDL-C:P1=0.004,P2=0.039),颅内合并颅外动脉病变组男性比例高于颅内动脉病变组(P=0.003).结论 脑梗死患者颅内动脉粥样硬化性狭窄多于颅外,单纯颅内动脉狭窄组血脂控制欠佳,大多数传统的动脉粥样硬化危险因素并不是动脉狭窄发生部位的决定因子.

Abstract：

Objective To investigate the distribution of atherosclerotic stenosis of cerebral arteries in Chinese patients suffered from cerebral infarction,and to determine if there are any factors correlating with intracranial and extracranial atherosclerosis.Methods For this study,we enrolled 428 consecutive inpatients with cerebral infarction,All patients were examined with transcranial Doppler ultrasonography (TCD) and carotid duplex ultrasound to detect atherosclerotic lesions in intracranial and extracranial cerebral arteries,some also were examined by magnetic resonance angiography (MRA) and/or digital subtraction angiography(DSA),they were all diagnosed as atherosclerotic cerebral artery stenosis.The patients were divided into three groups according to the different location of lesions,the frequency of risk factors of atherosclerosis and the demographic parameters were compared among these groups.Results 199 cases (46.5%) had only intracranial artery stenosis,129 cases (30.1%) had only extracranial artery stenosis,100 cases (23.4%) had both intracranial and extracranial stenosis (combine group).Compared with the other two groups,the levels of total cholesterol and low density lipoprotein-cholesterol of the intracranial artery group are both significantly higher(TC:P1 = 0.001,P2 = 0.000;LDL-C:P1 = 0.004,P2 = 0.039),the combine group had a significant higher ratio of male than that of the intracranial artery group (P =0.003),there were no any other atherosclerosis risk factors had association with the location of cerebral artery stenosis.Conclusion The occurrence of stenosis in intracranial arteries is more frequent than that in extracranil arteries in Chinese patients with cerebral infarction,and the lipid level is higher in the intracranial artery group,most risk factors of atherosclerosis may not be major determinants of location for cerebral atherosclerosis.

Atherosclerotic stenosis of intracranial and extracranial cerebral arteries in patients with cerebral infarction and the correlative factors

Objective To investigate the distribution of atherosclerotic stenosis of cerebral arteries in Chinese patients suffered from cerebral infarction,and to determine if there are any factors correlating with intracranial and extracranial atherosclerosis.Methods For this study,we enrolled 428 consecutive inpatients with cerebral infarction,All patients were examined with transcranial Doppler ultrasonography (TCD) and carotid duplex ultrasound to detect atherosclerotic lesions in intracranial and extracranial cerebral arteries,some also were examined by magnetic resonance angiography (MRA) and/or digital subtraction angiography(DSA),they were all diagnosed as atherosclerotic cerebral artery stenosis.The patients were divided into three groups according to the different location of lesions,the frequency of risk factors of atherosclerosis and the demographic parameters were compared among these groups.Results 199 cases (46.5%) had only intracranial artery stenosis,129 cases (30.1%) had only extracranial artery stenosis,100 cases (23.4%) had both intracranial and extracranial stenosis (combine group).Compared with the other two groups,the levels of total cholesterol and low density lipoprotein-cholesterol of the intracranial artery group are both significantly higher(TC:P1 = 0.001,P2 = 0.000;LDL-C:P1 = 0.004,P2 = 0.039),the combine group had a significant higher ratio of male than that of the intracranial artery group (P =0.003),there were no any other atherosclerosis risk factors had association with the location of cerebral artery stenosis.Conclusion The occurrence of stenosis in intracranial arteries is more frequent than that in extracranil arteries in Chinese patients with cerebral infarction,and the lipid level is higher in the intracranial artery group,most risk factors of atherosclerosis may not be major determinants of location for cerebral atherosclerosis.