中国儿童侵袭性肺炎链球菌耐红霉素株的流行病学特征 |
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引用本文: | 马香,杨永弘,姚开虎,谢贵林,郑跃杰,王传清,尚云晓,王慧云,万莉雅,刘岚,Changchong Li,徐樨巍,季伟,王亚亭,徐佩茹,俞桑洁.中国儿童侵袭性肺炎链球菌耐红霉素株的流行病学特征[J].中华医学杂志(英文版),2013,126(8). |
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作者姓名: | 马香 杨永弘 姚开虎 谢贵林 郑跃杰 王传清 尚云晓 王慧云 万莉雅 刘岚 Changchong Li 徐樨巍 季伟 王亚亭 徐佩茹 俞桑洁 |
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作者单位: | Beijing Children's Hospital,首都医科大学附属北京儿童医院,Beijing Children's Hospital,Lanzhou Institute of Biological Products,Shenzhen Children’s Hospital, Shenzhen, China,Pediatric Hospital of Fudan University,,Shengjing Hospital Affiliated to China Medical University,,Nanjing Children’s Hospital, Nanjing, China,Tianjin Children’s Hospital,,Chongqing Children’s Hospital Affiliated to Chongqing Medical University,Yuying Children’s Hospital Affiliated to Wenzhou Medical College,,Beijing Children‘s Hospital,Suzhou University Pediatric,lAnhui Medical University Affiliated Hospital,,First Affiliated Hospital of Xinjiang Medical University,,Beijing Children's Hospital |
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摘 要: | 目的:检测中国儿童侵袭性肺炎链球菌耐红霉素株的耐药基因,并分析其流行病学特征。方法:对2006-2008年间从全国11个医疗中心收取的,共171株侵袭性肺炎链球菌株进行血清分型和药敏试验。对其中耐红霉素株进行耐药基因检测、多位点序列分析和脉冲场凝胶电泳分析。结果:共有164株(95.9%)对红霉素耐药,除了2株细菌以外都呈现出高水平耐药(MIC≥256μg/ml)。其中有104(63.4%)株只携带ermB基因,59(36.0%)株同时携带ermB和mefA基因,仅1株细菌单独携带mefA基因。同时携带2个耐药基因的血清型主要是19A和19F,它们都显示同样的PFGE形式(C型)。结论:中国儿童的侵袭性肺炎链球菌红霉素耐药率很高,其主要的耐药机制是由ermB基因介导的。同时携带ermB 和mefA两种耐药基因的血清型主要是19A和19F,它们与Taiwan19F-14 克隆具有遗传相关性。
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关 键 词: | 肺炎链球菌,红霉素耐药基因,儿童 |
Characterization of Erythromycin-resistant Streptococcus pneumoniae Isolates that Cause Invasive Diseases in Chinese Children |
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Abstract: | |
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Keywords: | Streptococcus pneumonia invasive pneumococcal diseases erythromycin resistance genes |
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