血管性痴呆认知功能障碍与海马线粒体功能异常的机制研究进展

海马线粒体功能异常与血管性痴呆认知功能密切相关。本文从海马线粒体功能异常，包括线粒体细胞自噬、凋亡途径异常、氧化损伤、生物合成功能异常、动力学失衡、钙稳态失衡、呼吸功能异常7个方面，分别探讨其与血管性痴呆认知功能障碍之间的内在机制。通过分析文献，提示海马线粒体功能异常是造成血管性痴呆认知功能障碍的重要原因之一，为今后临床预防与改善血管性痴呆认知功能障碍的治疗提供新思路和有效途径。

Pathogenesis of Cognitive Deficits Induced by Hippocampal Mitochondrial Dysfunction in Vascular Dementia: a Review of the Latest Developments

Hippocampal mitochondrial dysfunction is closely related to cognitive deficits in vascular dementia. We reviewed the latest developments in the internal associations of hippocampal mitochondrial dysfunction with cognitive deficits in vascular dementia, which mainly encompass seven aspects: abnormal mitochondrial autophagy, abnormal apoptotic pathway, oxidative damage, abnormal biosynthetic function, dynamic imbalance, imbalance of calcium homeostasis and abnormal respiratory function. According to the evidence, hippocampal mitochondrial dysfunction may be a major cause of cognitive impairment in vascular dementia, which provides insights into the development of new ideas and effective ways for clinical prevention and improvement of cognitive function in vascular dementia.