七叶皂苷素治疗血瘀风燥型皮肤瘙痒症的临床研究

目的 :观察活血化瘀药物七叶皂苷素对血瘀风燥型皮肤瘙痒症的临床疗效 ,以期验证中医学“治风先治血 ,血行风自灭”的传统理论。方法 :将辨证属于血瘀风燥型的皮肤瘙痒症患者 5 1例 ,按照随机对照方法分组。治疗组 30例 ,予口服七叶皂苷素片 ,30 0mg/次 ,2次 /d ;对照组 2 1例 ,予口服抗组胺药物氯雷他啶 ,10mg/次 ,1次 /d。两组均以 2周为 1个疗程 ,用药2个疗程后按症状积分下降指数 (symptomscorereducingindex ,SSRI)分别从瘙痒值、皮损分布面积、皮损形态三方面计算各组皮肤瘙痒的控制程度。结果 :治疗组用药 2周临床总有效率为 6 3.3% ,4周为 86 .7% ;对照组 2周临床总有效率为 6 7.0 % ,4周为 80 .0 % ,两者疗效比较无统计学差异。分类积分显示 ,瘙痒值、皮损形态两组无统计学差异 ;而皮损分布面积治疗组明显优于对照组 (P <0 .0 5 )。结论 :七叶皂苷素对血瘀风燥型皮肤瘙痒症疗效肯定 ,并印证了中医“治风先治血 ,血行风自灭”的理论。

Clinical effect of escin on patients with cutaneous pruritus caused by blood stasis and wind-dryness

OBJECTIVE: To observe the clinical effect of escin on patients with cutaneous pruritus caused by blood stasis and wind-dryness and to prove the theory that "wind should be treated by regulating blood disorder, and wind disappears after activating blood" in traditional Chinese medicine (TCM). METHODS: Fifty-one patients were randomly divided into escin-treated group (n=30) and loratadine-treated group (n=21). The patients in the escin-treated group were treated with escin for 4 weeks (300 mg, b.i.d.), and the patients in the loratadine-treated group were treated with loratadine (10 mg, q.d.). Symptom score reducing index (SSRI) was used to assess the pruritus degree, lesion range and lesion shape before the treatment, 2 weeks and 4 weeks after the treatment, respectively. RESULTS: Two weeks after the treatment, the effective rate of the escin-treated group was 63.3%, and the effective rate of the loratadine-treated group was 67.0%. Four weeks after the treatment, the effective rates were 86.7% and 80.0% in escin- and loratadine-treated groups respectively. There was no statistical difference in total scores of SSRI in two groups (P>0.05), and the scores of pruritus degree and lesion shape also had no statistical difference (P>0.05), while the score of lesion range of the escin-treated group was lower than that of the loratadine-treated group (P<0.05). CONCLUSION: Escin has satisfactory effect in treating pruritus caused by blood stasis and wind-dryness. The study confirms the TCM theory that "wind should be treated by regulating blood disorder, and wind disappears after activating blood".